EFSA Compendium of Botanicals

Draft - work in progress

Glaucium flavum Crantz

Family:: Papavaraceae
Approval state:: Approved
Number of articles retrieved:: 285
Number of processed references:: 6

Compositions

#1: glaucine in grass #2: allocryptopine #3: isocorydine #4: protopine #5: glaucine #6: chelidonine #7: N,N-dimethylhernovine #8: protopine #9: sanguinarine #10: protopine, aerial part #11: protopine, root #12: Glaucine (Isoquinoline alkaloid) #13: Isoboldine (isoquinoline alkaloid) #14: Isoquinoline alkaloids #15: Oxoglaucine (isoquinoline alkaloid) #16: Thaliporphine (isoquinoline alkaloid)

Endpoint Studies

#1: LD50 in mice

Genotoxicity

Composition #1: Buzuk, G. N., Lovkova, M. Ya., Grinkevich, N. I. Quantitative determination of glaucine in Glaucium flavum Crantz. by thin-layer chromatography and spectrophotometry. prikladnaya biokhimiya i mikrobiologiya, 1980, vol. 16, no. 3, p. 432–8. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Substance:

glaucine (RF-00003838-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Analytical method - additional description:

spectometry
Result unit:

Microgram (G283A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5-20
Internal remarks:

glaucine in grass

Composition #2: Gozler, Tekant., Unluyol, Serpil. Alkaloids from the flowers of Glaucium flavum Crantz (Papaveraceae). doga bilim dergisi, seri c: tip, 1981, vol. 5, no. 1, p. 25–6. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Substance:

allocryptopine (RF-00004136-PAR)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

allocryptopine

Composition #3: Gozler, Tekant., Unluyol, Serpil. Alkaloids from the flowers of Glaucium flavum Crantz (Papaveraceae). doga bilim dergisi, seri c: tip, 1981, vol. 5, no. 1, p. 25–6. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Substance:

isocorydine (RF-00003443-PAR)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

isocorydine

Composition #4: Gozler, Tekant., Unluyol, Serpil. Alkaloids from the flowers of Glaucium flavum Crantz (Papaveraceae). doga bilim dergisi, seri c: tip, 1981, vol. 5, no. 1, p. 25–6. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Substance:

protopine (RF-00004010-PAR)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

protopine

Composition #5: Och, Anna., Szewczyk, Katarzyna., Pecio, Lukasz., Stochmal, Anna., Zaluski, Daniel., Bogucka-Kocka, Anna. UPLC-MS/MS Profile of Alkaloids with Cytotoxic Properties of Selected Medicinal Plants of the Berberidaceae and Papaveraceae Families. . oxidative medicine and cellular longevity, 2017, vol. 2017, p. 9369872–9369872. DOI: 10.1155/2017/9369872. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

glaucine (RF-00003838-PAR)
Analytical method code:

UHPLC-MS-MS (F608A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

glaucine

Composition #6: Och, Anna., Szewczyk, Katarzyna., Pecio, Lukasz., Stochmal, Anna., Zaluski, Daniel., Bogucka-Kocka, Anna. UPLC-MS/MS Profile of Alkaloids with Cytotoxic Properties of Selected Medicinal Plants of the Berberidaceae and Papaveraceae Families. . oxidative medicine and cellular longevity, 2017, vol. 2017, p. 9369872–9369872. DOI: 10.1155/2017/9369872. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

chelidonine (RF-00004205-PAR)
Analytical method code:

UHPLC-MS-MS (F608A)
Result unit:

Microgram/gram (G049A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

650.0
Internal remarks:

chelidonine

Composition #7: Och, Anna., Szewczyk, Katarzyna., Pecio, Lukasz., Stochmal, Anna., Zaluski, Daniel., Bogucka-Kocka, Anna. UPLC-MS/MS Profile of Alkaloids with Cytotoxic Properties of Selected Medicinal Plants of the Berberidaceae and Papaveraceae Families. . oxidative medicine and cellular longevity, 2017, vol. 2017, p. 9369872–9369872. DOI: 10.1155/2017/9369872. [DOI link]

Language:

English (en)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

hernovine (RF-00011235-PAR)
Additional substance description:

N,N-dimethylhernovine
Analytical method code:

UHPLC-MS-MS (F608A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

N,N-dimethylhernovine

Composition #8: Och, Anna., Szewczyk, Katarzyna., Pecio, Lukasz., Stochmal, Anna., Zaluski, Daniel., Bogucka-Kocka, Anna. UPLC-MS/MS Profile of Alkaloids with Cytotoxic Properties of Selected Medicinal Plants of the Berberidaceae and Papaveraceae Families. . oxidative medicine and cellular longevity, 2017, vol. 2017, p. 9369872–9369872. DOI: 10.1155/2017/9369872. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

protopine (RF-00004010-PAR)
Analytical method code:

UHPLC-MS-MS (F608A)
Result unit:

Microgram/gram (G049A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4990
Internal remarks:

protopine

Composition #9: Och, Anna., Szewczyk, Katarzyna., Pecio, Lukasz., Stochmal, Anna., Zaluski, Daniel., Bogucka-Kocka, Anna. UPLC-MS/MS Profile of Alkaloids with Cytotoxic Properties of Selected Medicinal Plants of the Berberidaceae and Papaveraceae Families. . oxidative medicine and cellular longevity, 2017, vol. 2017, p. 9369872–9369872. DOI: 10.1155/2017/9369872. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

sanguinarine (RF-00004040-PAR)
Analytical method code:

UHPLC-MS-MS (F608A)
Result unit:

Microgram/gram (G049A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

407.4
Internal remarks:

sanguinarine

Composition #10: Bournine, Lamine., Bensalem, Sihem., Wauters, Jean-Noel., Iguer-Ouada, Mokrane., Maiza-Benabdesselam, Fadila., Bedjou, Fatiha., Castronovo, Vincent., Bellahcene, Akeila., Tits, Monique., Frederich, Michel. Identification and Quantification of the Main Active Anticancer Alkaloids from the Root of Glaucium flavum . international journal of molecular sciences, 2013, vol. 14, no. 12, p. 23533–23544. DOI: 10.3390/ijms141223533. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

protopine (RF-00004010-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.08
Internal remarks:

protopine, aerial part

Composition #11: Bournine, Lamine., Bensalem, Sihem., Wauters, Jean-Noel., Iguer-Ouada, Mokrane., Maiza-Benabdesselam, Fadila., Bedjou, Fatiha., Castronovo, Vincent., Bellahcene, Akeila., Tits, Monique., Frederich, Michel. Identification and Quantification of the Main Active Anticancer Alkaloids from the Root of Glaucium flavum . international journal of molecular sciences, 2013, vol. 14, no. 12, p. 23533–23544. DOI: 10.3390/ijms141223533. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

protopine (RF-00004010-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.84
Internal remarks:

protopine, root

Composition #12: Ivanovska, N., Philipov, S. Comparative study on the immunological activity of a series of isoquinoline alkaloids . phytotherapy research, 1996, vol. 10, no. 1, p. 62–65. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

glaucine (RF-00003838-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Glaucine (Isoquinoline alkaloid)

Composition #13: Ivanovska, N., Philipov, S. Comparative study on the immunological activity of a series of isoquinoline alkaloids . phytotherapy research, 1996, vol. 10, no. 1, p. 62–65. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

isoboldine (RF-00003879-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoboldine (isoquinoline alkaloid)

Composition #14: Ivanovska, N., Philipov, S. Comparative study on the immunological activity of a series of isoquinoline alkaloids . phytotherapy research, 1996, vol. 10, no. 1, p. 62–65. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoquinoline alkaloids

Composition #15: Ivanovska, N., Philipov, S. Comparative study on the immunological activity of a series of isoquinoline alkaloids . phytotherapy research, 1996, vol. 10, no. 1, p. 62–65. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Oxoglaucine (RF-00011146-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Oxoglaucine (isoquinoline alkaloid)

Composition #16: Ivanovska, N., Philipov, S. Comparative study on the immunological activity of a series of isoquinoline alkaloids . phytotherapy research, 1996, vol. 10, no. 1, p. 62–65. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Thaliporphine (RF-00004077-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Thaliporphine (isoquinoline alkaloid)

Endpoint study #1: Scholar, E. Glaucine. xpharm: the comprehensive pharmacology reference, 2011, p. 1–4. DOI: 10.1016/B978-008055232-3.61825-2. [DOI link]

Study relevance:

Human health
Substance:

glaucine (RF-00003838-PAR)
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

No data
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Control groups used:

no data
Endpoint measured:

Lethal dose rate in 50% of experimental organisms (CHD029EP)
Concentration unit:

Milligrams per day (G209A)
Effect concentration:

401
Critical effect:

Other toxicities (TOX19A)
Effect description:

LD50
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

LD50 in mice