EFSA Compendium of Botanicals

Draft - work in progress

Glaucium corniculatum (L.) Curtis

Family:: Papavaraceae
Approval state:: Approved
Number of articles retrieved:: 54
Number of processed references:: 6

Compositions

#1: alkaloids, aerial part #2: alkaloids, aerial part, quantified #3: alkaloids (corydine, isocorydine, protopine, alpha-allocryptopine and talicmidine), aerial part, quantified #4: cryptopine in aerial part #5: glaucine in aerial part #6: Aporphine alkaloids (N-methyllaurotetanine, norglaucine, corunnine) in aerial part #7: isoboldine in aerial part #8: Benzophenanthridine alkaloid (chelitrytryne) in aerial part #9: sanguinarine in aerial part #10: chelidonine in aerial part #11: isoquinoline alkaloids (berbitine, corydaine) in aerial part #12: Alkaloids (allocryptopine, protopine, corydine, isocorydine and berberine), whole plant #13: dicentrine in aerial parts #14: aporphine alkaloid (dehydrodicentrine) in aerial parts #15: bulbocapnine in aerial parts

Endpoint Studies

Genotoxicity

Composition #1: Israilov, I.A., Karimova, S.U., Denisenko, O.N., Yunusov, M.S., Murav'eva, D.A., Yunusov, S.Yu. Alkaloids of Glaucium corniculatum. chemistry of natural compounds, 1983, vol. 19, no. 6, p. 714–716. DOI: 10.1007/BF00575177. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

e.g. protopine, allocryptopine, corydine, norbractyolin, dehydrocorydine, predicentrine, glaufidine, thalicmidine, reticulin, and stylopine alpha-methohydroxide
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

NMR, UV, IR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

alkaloids, aerial part

Composition #2: Kocanci, F.G., Hamamcioglu, B., Aslim, B. The anti-AChE and anti-proliferative Activities of Glaucium acutidentatum and Glaucium corniculatum Alkaloid Extracts. journal of applied pharmaceutical science, 2017, vol. 7, no. 8, p. 191–200. DOI: 10.7324/JAPS.2017.70826. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol or water
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

UV/VIS spectroscopy (photometry) (F009A)
Result unit:

Milligram/gram (G060A)
Result expression:

Reconstituted product (B007A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

76.65-100.61
Internal remarks:

alkaloids, aerial part, quantified

Composition #3: Kintsurashvili, LG., Vachnadze, VY. Alkaloids of Glaucium corniculatum and G-flavum growing in Georgia. chemistry of natural compounds, 2000, vol. 36, no. 2, p. 225–226. DOI: 10.1007/BF02236441. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

corydine, isocorydine, protopine, alpha-allocryptopine and talicmidine
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.46
Internal remarks:

alkaloids (corydine, isocorydine, protopine, alpha-allocryptopine and talicmidine), aerial part, quantified

Composition #4: Doncheva, Tsvetelina., Kostova, Nadezhda., Yordanova, Gabriela., Saadi, Houcine., Akrib, Fadila., Dimitrov, Dimitar., Philipov, Stefan. Comparison of alkaloid profile from Glaucium corniculatum (Papaveraceae) of Algerian and Bulgarian origin . biochemical systematics and ecology, 2014, vol. 56, p. 278–280. DOI: 10.1016/j.bse.2014.07.007. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 95%
Substance:

cryptopine (RF-00004231-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cryptopine in aerial part

Composition #5: Doncheva, Tsvetelina., Kostova, Nadezhda., Yordanova, Gabriela., Saadi, Houcine., Akrib, Fadila., Dimitrov, Dimitar., Philipov, Stefan. Comparison of alkaloid profile from Glaucium corniculatum (Papaveraceae) of Algerian and Bulgarian origin . biochemical systematics and ecology, 2014, vol. 56, p. 278–280. DOI: 10.1016/j.bse.2014.07.007. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 95%
Substance:

glaucine (RF-00003838-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

glaucine in aerial part

Composition #6: Doncheva, Tsvetelina., Kostova, Nadezhda., Yordanova, Gabriela., Saadi, Houcine., Akrib, Fadila., Dimitrov, Dimitar., Philipov, Stefan. Comparison of alkaloid profile from Glaucium corniculatum (Papaveraceae) of Algerian and Bulgarian origin . biochemical systematics and ecology, 2014, vol. 56, p. 278–280. DOI: 10.1016/j.bse.2014.07.007. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 95%
Substance:

Aporphine alkaloids (RF-00010806-PAR)
Additional substance description:

N-methyllaurotetanine, norglaucine, corunnine
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Aporphine alkaloids (N-methyllaurotetanine, norglaucine, corunnine) in aerial part

Composition #7: Doncheva, Tsvetelina., Kostova, Nadezhda., Yordanova, Gabriela., Saadi, Houcine., Akrib, Fadila., Dimitrov, Dimitar., Philipov, Stefan. Comparison of alkaloid profile from Glaucium corniculatum (Papaveraceae) of Algerian and Bulgarian origin . biochemical systematics and ecology, 2014, vol. 56, p. 278–280. DOI: 10.1016/j.bse.2014.07.007. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 95%
Substance:

isoboldine (RF-00003879-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

isoboldine in aerial part

Composition #8: Doncheva, Tsvetelina., Kostova, Nadezhda., Yordanova, Gabriela., Saadi, Houcine., Akrib, Fadila., Dimitrov, Dimitar., Philipov, Stefan. Comparison of alkaloid profile from Glaucium corniculatum (Papaveraceae) of Algerian and Bulgarian origin . biochemical systematics and ecology, 2014, vol. 56, p. 278–280. DOI: 10.1016/j.bse.2014.07.007. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 95%
Substance:

benzophenanthridine alkaloids (RF-00010802-PAR)
Additional substance description:

chelitrytryne,
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

NRM
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Benzophenanthridine alkaloid (chelitrytryne) in aerial part

Composition #9: Doncheva, Tsvetelina., Kostova, Nadezhda., Yordanova, Gabriela., Saadi, Houcine., Akrib, Fadila., Dimitrov, Dimitar., Philipov, Stefan. Comparison of alkaloid profile from Glaucium corniculatum (Papaveraceae) of Algerian and Bulgarian origin . biochemical systematics and ecology, 2014, vol. 56, p. 278–280. DOI: 10.1016/j.bse.2014.07.007. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 95%
Substance:

sanguinarine (RF-00004040-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

sanguinarine in aerial part

Composition #10: Doncheva, Tsvetelina., Kostova, Nadezhda., Yordanova, Gabriela., Saadi, Houcine., Akrib, Fadila., Dimitrov, Dimitar., Philipov, Stefan. Comparison of alkaloid profile from Glaucium corniculatum (Papaveraceae) of Algerian and Bulgarian origin . biochemical systematics and ecology, 2014, vol. 56, p. 278–280. DOI: 10.1016/j.bse.2014.07.007. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 95%
Substance:

chelidonine (RF-00004205-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

chelidonine in aerial part

Composition #11: Doncheva, Tsvetelina., Kostova, Nadezhda., Yordanova, Gabriela., Saadi, Houcine., Akrib, Fadila., Dimitrov, Dimitar., Philipov, Stefan. Comparison of alkaloid profile from Glaucium corniculatum (Papaveraceae) of Algerian and Bulgarian origin . biochemical systematics and ecology, 2014, vol. 56, p. 278–280. DOI: 10.1016/j.bse.2014.07.007. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 95%
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

berbitine, corydaine
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

isoquinoline alkaloids (berbitine, corydaine) in aerial part

Composition #12: PHILLIPSON, JD., GRAY, AI., ASKARI, AAR., KHALIL, AA. ALKALOIDS FROM IRAQI SPECIES OF PAPAVERACEAE. journal of natural products, 1981, vol. 44, no. 3, p. 296–307. DOI: 10.1021/np50015a011. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

allocryptopine, protopine, corydine, isocorydine and berberine
Analytical method code:

Traditional analytical techniques (wet chemical tests) (F003A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids (allocryptopine, protopine, corydine, isocorydine and berberine), whole plant

Composition #13: SHAFIEE, A., GHANBARPOUR, A., AKHLAGHI, S. ALKALOIDS OF PAPAVERACEAE .12. ALKALOIDS OF GLAUCIUM-CORNICULATUM SUBSPECIES REFRACTUM, POPULATION POL-DOKHTAR . journal of natural products, 1985, vol. 48, no. 5, p. 855–856. DOI: 10.1021/np50041a037. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

dicentrine (RF-00003772-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

dicentrine in aerial parts

Composition #14: SHAFIEE, A., GHANBARPOUR, A., AKHLAGHI, S. ALKALOIDS OF PAPAVERACEAE .12. ALKALOIDS OF GLAUCIUM-CORNICULATUM SUBSPECIES REFRACTUM, POPULATION POL-DOKHTAR . journal of natural products, 1985, vol. 48, no. 5, p. 855–856. DOI: 10.1021/np50041a037. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Aporphine alkaloids (RF-00010806-PAR)
Additional substance description:

dehydrodicentrine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

aporphine alkaloid (dehydrodicentrine) in aerial parts

Composition #15: SHAFIEE, A., GHANBARPOUR, A., AKHLAGHI, S. ALKALOIDS OF PAPAVERACEAE .12. ALKALOIDS OF GLAUCIUM-CORNICULATUM SUBSPECIES REFRACTUM, POPULATION POL-DOKHTAR . journal of natural products, 1985, vol. 48, no. 5, p. 855–856. DOI: 10.1021/np50041a037. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

bulbocapnine (RF-00003719-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

bulbocapnine in aerial parts