EFSA Compendium of Botanicals

Draft - work in progress

Garcinia indica (Thouars) Choisy

Family:: Clusiaceae
Approval state:: Approved
Number of articles retrieved:: 422
Number of processed references:: 3

Compositions

#1: Hydroxycitric acid (fruits RIND) #2: Tannin (UNSPECIFIED)

Endpoint Studies

Genotoxicity

#1: fruit-rind of G. indica is genotoxic in mice

Composition #1: Kaur, Ranjeet., Chattopadhyay, Sunil K., Tandon, Sudeep., Sharma, Shelly. Large scale extraction of the fruits of Garcinia indica for the isolation of new and known polyisoprenylated benzophenone derivatives . industrial crops and products, 2012, vol. 37, no. 1, p. 420–426. DOI: 10.1016/j.indcrop.2011.12.031. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH, H2O
Substance:

(-) Hydroxycitric acid (HCA) (RF-00003432-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Hydroxycitric acid (fruits RIND)

Composition #2: MAKKAR, HPS., SINGH, B., NEGI, SS. TANNIN LEVELS AND THEIR DEGREE OF POLYMERIZATION AND SPECIFIC ACTIVITY IN SOME AGROINDUSTRIAL BY-PRODUCTS . biological wastes, 1990, vol. 31, no. 2, p. 137–144. DOI: 10.1016/0269-7483(90)90167-Q. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol, acetone
Substance:

Tannins (RF-00004337-PAR)
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

36.92-41.02
Internal remarks:

Tannin (UNSPECIFIED)

Genotox #1: Das, Aparajita., Ghosh, Ilika., Mukherjee, Anita. Garcinia indica fruit extract induces genotoxicity in mice. nucleus-india, 2016, vol. 59, no. 1, p. 1–6. DOI: 10.1007/s13237-015-0145-0. [DOI link]

Study category:

Genotoxicity
Type of toxicological test:

chromosome aberration assay (CHD047TT)
Method type:

in vivo
Tested organism:

Mammals (as animal) (A056H)
Strain of test organism:

bone marrow (CHD045ST)
Sex:

No data
Exogenous metabolic activation applied:

no data
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Number of organisms dosed:

1
Control groups used:

yes
Endpoint measured:

chromosome aberration
Is genotoxic:

Positive
Remarks on genotox study:

fruit-rind of G. indica is genotoxic in mice.
Internal remarks:

fruit-rind of G. indica is genotoxic in mice
Internal ID:

WOS:000405533800001