EFSA
ecomole
vscht
  2. Garcinia hanburyi Hook.f.

Garcinia hanburyi Hook.f.

Family:
Clusiaceae
Approval state:
Approved
Number of articles retrieved:
202
Number of processed references:
6
Compositions
#1: morellin (and derivatives 7-methoxydeoxymorellin, 8,8a-Epoxymorellic acis, Dihydroisomorellin) - resin #2: xanthones - Forbesione, 2-isoprenylforbesione - resin #3: gambogic acid - resin #4: (–)-gambogic acid epigambogic acid - resin #5: gambogic acid - resin
Endpoint Studies
#1: damage on the kidney and liver - gambogic acid #2: Gambogic acid - skeletal malformations; decreased birth weight, litter size, live births
Genotoxicity
Composition #1: Reutrakul, Vichai., Anantachoke, Natthinee., Pohmakotr, Manat., Jaipetch, Thaworn., Sophasan, Samaisukh., Yoosook, Chalobon., Kasisit, Jittra., Napaswat, Chanita., Santisuk, Thawatchai., Tuchinda, Patoomratana. Cytotoxic and anti-HIV-1 caged xanthones from the resin and fruits of Garcinia hanburyi . planta medica, 2007, vol. 73, no. 1, p. 33–40. DOI: 10.1055/s-2006-951748. [DOI link]
Composition #2: Reutrakul, Vichai., Anantachoke, Natthinee., Pohmakotr, Manat., Jaipetch, Thaworn., Sophasan, Samaisukh., Yoosook, Chalobon., Kasisit, Jittra., Napaswat, Chanita., Santisuk, Thawatchai., Tuchinda, Patoomratana. Cytotoxic and anti-HIV-1 caged xanthones from the resin and fruits of Garcinia hanburyi . planta medica, 2007, vol. 73, no. 1, p. 33–40. DOI: 10.1055/s-2006-951748. [DOI link]
Composition #3: Tao, Si-Jia., Guan, Shu-Hong., Wang, Wei., Lu, Zhi-Qiang., Chen, Guang-Tong., Sha, Na., Yue, Qing-Xi., Liu, Xuan., Guo, De-An. Cytotoxic Polyprenylated Xanthones from the Resin of Garcinia hanburyi. journal of natural products, 2009, vol. 72, no. 1, p. 117–124. DOI: 10.1021/np800460b. [DOI link]
Composition #4: Xu, Min., Fu, Wenwei., Zhang, Baojun., Tan, Hongsheng., Xiu, Yanfeng., Xu, Hongxi. Combinative application of pH-zone-refining and conventional high-speed counter-current chromatography for preparative separation of caged polyprenylated xanthones from gamboge . journal of separation science, 2016, vol. 39, no. 3, p. 559–565. DOI: 10.1002/jssc.201500996. [DOI link]
Composition #5: LIN, LJ., LIN, LZ., PEZZUTO, JM., CORDELL, GA., RUANGRUNGSI, N. ISOGAMBOGIC ACID AND ISOMORELLINOL FROM GARCINIA-HANBURYI. magnetic resonance in chemistry, 1993, vol. 31, no. 4, p. 340–347. DOI: 10.1002/mrc.1260310406. [DOI link]
Endpoint study #1: Qi, Qi., You, Qidong., Gu, Hongyan., Zhao, Li., Liu, Wei., Lu, Na., Guo, Qinglong. Studies on the toxicity of gambogic acid in rats. journal of ethnopharmacology, 2008, vol. 117, no. 3, p. 433–438. DOI: 10.1016/j.jep.2008.02.027. [DOI link]
Endpoint study #2: Zhao, Li., Zhen, Chen., Wu, Zhaoqiu., Hu, Rong., Zhou, Changlin., Guo, Qinglong. General pharmacological properties, developmental toxicity, and analgesic activity of gambogic acid, a novel natural anticancer agent . drug and chemical toxicology, 2010, vol. 33, no. 1, p. 88–96. DOI: 10.3109/01480540903173534. [DOI link]