EFSA
ecomole
vscht
  2. Fritillaria thunbergii Miq. // Fritillaria thunbergii var. chekiangensis P.K.Hsiao & K.C.Hsia

Fritillaria thunbergii Miq. // Fritillaria thunbergii var. chekiangensis P.K.Hsiao & K.C.Hsia

Family:
Liliaceae
Approval state:
Approved
Number of articles retrieved:
995
Number of processed references:
7
Compositions
#1: Peimisine (a steroidal alkaloid) in bulbs #2: Verticine in bulbs #3: Isovercitine, a derivative of vercitine #4: Puqiedinone (steroidal alkaloid) in bulbs #5: Verticine N-oxide in bulbs #6: Ebeiedinone (a steroidal alkaloid) in bulbs #7: Verticinone (a steroidal alkaloid) in bulbs #8: Verticinone (bulb) #9: Ebeiedine (bulb) #10: Ebeiedinone (bulb) #11: Verticine (bulb) #12: Peimissine (bulb) #13: Ebeiedinone (bulb) #14: Verticine (bulb) #15: Isoverticine (bulb) #16: Verticinone (bulb) #17: Pemine (bulb) #18: Peiminine (bulb) #19: dongbeinine and dongbeirine (bulb) #20: zhebeinine (bulb) #21: Isoverticine in crude extract (bulb) #22: Verticine in crude extract (bulb) #23: Ebeiedinone in crude extract (bulb) #24: Verticinone in crude extract (bulb) #25: Ebeiedine in crude extract (bulb)
Endpoint Studies
#1: LD50 for an extract of the root in mice #2: 3 mg/kg dose of extract of bulb: body or head tremor and spontaneous motor activity in male rats.
Genotoxicity
Composition #1: Zhou, Jian-Liang., Li, Ping., Li, Hui-Jun., Jiang, Yan., Ren, Mei-Ting., Liu, Ying. Development and validation of a liquid chromatography/electrospray ionization time-of-flight mass spectrometry method for relative and absolute quantification of steroidal alkaloids in Fritillaria species. journal of chromatography a, 2008, vol. 1177, no. 1, p. 126–137. .
Composition #2: Zhou, Jian-Liang., Li, Ping., Li, Hui-Jun., Jiang, Yan., Ren, Mei-Ting., Liu, Ying. Development and validation of a liquid chromatography/electrospray ionization time-of-flight mass spectrometry method for relative and absolute quantification of steroidal alkaloids in Fritillaria species. journal of chromatography a, 2008, vol. 1177, no. 1, p. 126–137. .
Composition #3: Zhou, Jian-Liang., Li, Ping., Li, Hui-Jun., Jiang, Yan., Ren, Mei-Ting., Liu, Ying. Development and validation of a liquid chromatography/electrospray ionization time-of-flight mass spectrometry method for relative and absolute quantification of steroidal alkaloids in Fritillaria species. journal of chromatography a, 2008, vol. 1177, no. 1, p. 126–137. .
Composition #4: Zhou, Jian-Liang., Li, Ping., Li, Hui-Jun., Jiang, Yan., Ren, Mei-Ting., Liu, Ying. Development and validation of a liquid chromatography/electrospray ionization time-of-flight mass spectrometry method for relative and absolute quantification of steroidal alkaloids in Fritillaria species. journal of chromatography a, 2008, vol. 1177, no. 1, p. 126–137. .
Composition #5: Zhou, Jian-Liang., Li, Ping., Li, Hui-Jun., Jiang, Yan., Ren, Mei-Ting., Liu, Ying. Development and validation of a liquid chromatography/electrospray ionization time-of-flight mass spectrometry method for relative and absolute quantification of steroidal alkaloids in Fritillaria species. journal of chromatography a, 2008, vol. 1177, no. 1, p. 126–137. .
Composition #6: Zhou, Jian-Liang., Li, Ping., Li, Hui-Jun., Jiang, Yan., Ren, Mei-Ting., Liu, Ying. Development and validation of a liquid chromatography/electrospray ionization time-of-flight mass spectrometry method for relative and absolute quantification of steroidal alkaloids in Fritillaria species. journal of chromatography a, 2008, vol. 1177, no. 1, p. 126–137. .
Composition #7: Zhou, Jian-Liang., Li, Ping., Li, Hui-Jun., Jiang, Yan., Ren, Mei-Ting., Liu, Ying. Development and validation of a liquid chromatography/electrospray ionization time-of-flight mass spectrometry method for relative and absolute quantification of steroidal alkaloids in Fritillaria species. journal of chromatography a, 2008, vol. 1177, no. 1, p. 126–137. .
Composition #8: Li, SL., Chan, SW., Li, P., Lin, G., Zhou, GH., Ren, YJ., Chiu, FCK. Pre-column derivatization and gas chromatographic determination of alkaloids in bulbs of Fritillaria . journal of chromatography a, 1999, vol. 859, no. 2, p. 183–192. DOI: 10.1016/S0021-9673(99)00867-5. [DOI link]
Composition #9: Li, SL., Chan, SW., Li, P., Lin, G., Zhou, GH., Ren, YJ., Chiu, FCK. Pre-column derivatization and gas chromatographic determination of alkaloids in bulbs of Fritillaria . journal of chromatography a, 1999, vol. 859, no. 2, p. 183–192. DOI: 10.1016/S0021-9673(99)00867-5. [DOI link]
Composition #10: Li, SL., Chan, SW., Li, P., Lin, G., Zhou, GH., Ren, YJ., Chiu, FCK. Pre-column derivatization and gas chromatographic determination of alkaloids in bulbs of Fritillaria . journal of chromatography a, 1999, vol. 859, no. 2, p. 183–192. DOI: 10.1016/S0021-9673(99)00867-5. [DOI link]
Composition #11: Li, SL., Chan, SW., Li, P., Lin, G., Zhou, GH., Ren, YJ., Chiu, FCK. Pre-column derivatization and gas chromatographic determination of alkaloids in bulbs of Fritillaria . journal of chromatography a, 1999, vol. 859, no. 2, p. 183–192. DOI: 10.1016/S0021-9673(99)00867-5. [DOI link]
Composition #12: Li, SL., Lin, G., Chan, SW., Li, P. Determination of the major isosteroidal alkaloids in bulbs of Fritillaria by high-performance liquid chromatography coupled with evaporative light scattering detection . journal of chromatography a, 2001, vol. 909, no. 2, p. 207–214. DOI: 10.1016/S0021-9673(00)01083-9. [DOI link]
Composition #13: Li, SL., Lin, G., Chan, SW., Li, P. Determination of the major isosteroidal alkaloids in bulbs of Fritillaria by high-performance liquid chromatography coupled with evaporative light scattering detection . journal of chromatography a, 2001, vol. 909, no. 2, p. 207–214. DOI: 10.1016/S0021-9673(00)01083-9. [DOI link]
Composition #14: Li, SL., Lin, G., Chan, SW., Li, P. Determination of the major isosteroidal alkaloids in bulbs of Fritillaria by high-performance liquid chromatography coupled with evaporative light scattering detection . journal of chromatography a, 2001, vol. 909, no. 2, p. 207–214. DOI: 10.1016/S0021-9673(00)01083-9. [DOI link]
Composition #15: Li, SL., Lin, G., Chan, SW., Li, P. Determination of the major isosteroidal alkaloids in bulbs of Fritillaria by high-performance liquid chromatography coupled with evaporative light scattering detection . journal of chromatography a, 2001, vol. 909, no. 2, p. 207–214. DOI: 10.1016/S0021-9673(00)01083-9. [DOI link]
Composition #16: Li, SL., Lin, G., Chan, SW., Li, P. Determination of the major isosteroidal alkaloids in bulbs of Fritillaria by high-performance liquid chromatography coupled with evaporative light scattering detection . journal of chromatography a, 2001, vol. 909, no. 2, p. 207–214. DOI: 10.1016/S0021-9673(00)01083-9. [DOI link]
Composition #17: Long, Zhen., Guo, Zhimou., Acworth, Ian N., Liu, Xiaoda., Jin, Yan., Liu, Xingguo., Liu, Lvye., Liang, Lina. A non-derivative method for the quantitative analysis of isosteroidal alkaloids from Fritillaria by high performance liquid chromatography combined with charged aerosol detection . talanta, 2016, vol. 151, p. 239–244. DOI: 10.1016/j.talanta.2016.01.027. [DOI link]
Composition #18: Long, Zhen., Guo, Zhimou., Acworth, Ian N., Liu, Xiaoda., Jin, Yan., Liu, Xingguo., Liu, Lvye., Liang, Lina. A non-derivative method for the quantitative analysis of isosteroidal alkaloids from Fritillaria by high performance liquid chromatography combined with charged aerosol detection . talanta, 2016, vol. 151, p. 239–244. DOI: 10.1016/j.talanta.2016.01.027. [DOI link]
Composition #19: ZHANG, JX., AINA, L., XU, RS. STEROIDAL ALKALOIDS FROM FRITILLARIA-THUNBERGII VAR CHEKIANGENSIS. phytochemistry, 1993, vol. 33, no. 4, p. 946–947. DOI: 10.1016/0031-9422(93)85314-H. [DOI link]
Composition #20: ZHANG, JX., AINA, L., XU, RS. STEROIDAL ALKALOIDS FROM FRITILLARIA-THUNBERGII VAR CHEKIANGENSIS. phytochemistry, 1993, vol. 33, no. 4, p. 946–947. DOI: 10.1016/0031-9422(93)85314-H. [DOI link]
Composition #21: Ding, K., Lin, G., Ho, YP., Cheng, TY., Li, P. Prederivatization and high-performance liquid chromatographic analysis of alkaloids of bulbs of Fritillaria . journal of pharmaceutical sciences, 1996, vol. 85, no. 11, p. 1174–1179. DOI: 10.1021/js960211v. [DOI link]
Composition #22: Ding, K., Lin, G., Ho, YP., Cheng, TY., Li, P. Prederivatization and high-performance liquid chromatographic analysis of alkaloids of bulbs of Fritillaria . journal of pharmaceutical sciences, 1996, vol. 85, no. 11, p. 1174–1179. DOI: 10.1021/js960211v. [DOI link]
Composition #23: Ding, K., Lin, G., Ho, YP., Cheng, TY., Li, P. Prederivatization and high-performance liquid chromatographic analysis of alkaloids of bulbs of Fritillaria . journal of pharmaceutical sciences, 1996, vol. 85, no. 11, p. 1174–1179. DOI: 10.1021/js960211v. [DOI link]
Composition #24: Ding, K., Lin, G., Ho, YP., Cheng, TY., Li, P. Prederivatization and high-performance liquid chromatographic analysis of alkaloids of bulbs of Fritillaria . journal of pharmaceutical sciences, 1996, vol. 85, no. 11, p. 1174–1179. DOI: 10.1021/js960211v. [DOI link]
Composition #25: Ding, K., Lin, G., Ho, YP., Cheng, TY., Li, P. Prederivatization and high-performance liquid chromatographic analysis of alkaloids of bulbs of Fritillaria . journal of pharmaceutical sciences, 1996, vol. 85, no. 11, p. 1174–1179. DOI: 10.1021/js960211v. [DOI link]
Endpoint study #1: Li, Zehui., Qiao, Yuan., Li, Jianguo., An, Chao., Hu, Kaiwen., Tang, Minke. Acute and sub-chronic toxicity studies of the extract of Thunberg Fritillary Bulb . regulatory toxicology and pharmacology, 2014, vol. 68, no. 3, p. 370–377. DOI: 10.1016/j.yrtph.2014.01.007. [DOI link]
Endpoint study #2: Li, Zehui., Qiao, Yuan., Li, Jianguo., An, Chao., Hu, Kaiwen., Tang, Minke. Acute and sub-chronic toxicity studies of the extract of Thunberg Fritillary Bulb . regulatory toxicology and pharmacology, 2014, vol. 68, no. 3, p. 370–377. DOI: 10.1016/j.yrtph.2014.01.007. [DOI link]