Draft - work in progress
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- Fennel (as plant) // Foeniculum vulgare Mill.
Fennel (as plant) // Foeniculum vulgare Mill.
- Family:
- Apiaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 5425
- Number of processed references:
- 6
Composition #1: Nassar, Mahmoud I., Aboutabl, El-sayed A., Makled, Yousrya A., El-Khrisy, Ezzel-Din A., Osman, Abeer F. Secondary metabolites and pharmacology of Foeniculum vulgare Mill. Subsp. piperitum. revista latinoamericana de quimica, 2010, vol. 38, no. 2, p. 103–112. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methylene chloride
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Substance:
Isopimpinellin (RF-00003784-PAR)
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
isopimpinellin - aerial parts
Composition #2: Nassar, Mahmoud I., Aboutabl, El-sayed A., Makled, Yousrya A., El-Khrisy, Ezzel-Din A., Osman, Abeer F. Secondary metabolites and pharmacology of Foeniculum vulgare Mill. Subsp. piperitum. revista latinoamericana de quimica, 2010, vol. 38, no. 2, p. 103–112. .
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-
Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methylene chloride
-
Substance:
imperatorin (RF-00003874-PAR)
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
imperatorin - aerial parts
Composition #3: Nassar, Mahmoud I., Aboutabl, El-sayed A., Makled, Yousrya A., El-Khrisy, Ezzel-Din A., Osman, Abeer F. Secondary metabolites and pharmacology of Foeniculum vulgare Mill. Subsp. piperitum. revista latinoamericana de quimica, 2010, vol. 38, no. 2, p. 103–112. .
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-
Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methylene chloride
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Substance:
Bergapten (RF-00003837-PAR)
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
bergapten - fruit
Composition #4: Nassar, Mahmoud I., Aboutabl, El-sayed A., Makled, Yousrya A., El-Khrisy, Ezzel-Din A., Osman, Abeer F. Secondary metabolites and pharmacology of Foeniculum vulgare Mill. Subsp. piperitum. revista latinoamericana de quimica, 2010, vol. 38, no. 2, p. 103–112. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methylene chloride
-
Substance:
psoralen (RF-00004015-PAR)
-
Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
psoralen - aerial parts
Composition #5: Nassar, Mahmoud I., Aboutabl, El-sayed A., Makled, Yousrya A., El-Khrisy, Ezzel-Din A., Osman, Abeer F. Secondary metabolites and pharmacology of Foeniculum vulgare Mill. Subsp. piperitum. revista latinoamericana de quimica, 2010, vol. 38, no. 2, p. 103–112. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methylene chloride
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Substance:
Xanthotoxol (RF-00011114-PAR)
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Additional substance description:
xanthotoxin
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
xanthotoxin - aerial parts
Composition #6: Nassar, Mahmoud I., Aboutabl, El-sayed A., Makled, Yousrya A., El-Khrisy, Ezzel-Din A., Osman, Abeer F. Secondary metabolites and pharmacology of Foeniculum vulgare Mill. Subsp. piperitum. revista latinoamericana de quimica, 2010, vol. 38, no. 2, p. 103–112. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methylene chloride
-
Substance:
Bergapten (RF-00003837-PAR)
-
Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
bergapten - aerial parts
Composition #7: Nassar, Mahmoud I., Aboutabl, El-sayed A., Makled, Yousrya A., El-Khrisy, Ezzel-Din A., Osman, Abeer F. Secondary metabolites and pharmacology of Foeniculum vulgare Mill. Subsp. piperitum. revista latinoamericana de quimica, 2010, vol. 38, no. 2, p. 103–112. .
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methylene chloride
-
Substance:
imperatorin (RF-00003874-PAR)
-
Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
imperatorin - fruit
Composition #8: Nassar, Mahmoud I., Aboutabl, El-sayed A., Makled, Yousrya A., El-Khrisy, Ezzel-Din A., Osman, Abeer F. Secondary metabolites and pharmacology of Foeniculum vulgare Mill. Subsp. piperitum. revista latinoamericana de quimica, 2010, vol. 38, no. 2, p. 103–112. .
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methylene chloride
-
Substance:
Isopimpinellin (RF-00003784-PAR)
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
isopimpinellin - fruit
Composition #9: Nassar, Mahmoud I., Aboutabl, El-sayed A., Makled, Yousrya A., El-Khrisy, Ezzel-Din A., Osman, Abeer F. Secondary metabolites and pharmacology of Foeniculum vulgare Mill. Subsp. piperitum. revista latinoamericana de quimica, 2010, vol. 38, no. 2, p. 103–112. .
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methylene chloride
-
Substance:
psoralen (RF-00004015-PAR)
-
Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
psoralen - fruit
Composition #10: Nassar, Mahmoud I., Aboutabl, El-sayed A., Makled, Yousrya A., El-Khrisy, Ezzel-Din A., Osman, Abeer F. Secondary metabolites and pharmacology of Foeniculum vulgare Mill. Subsp. piperitum. revista latinoamericana de quimica, 2010, vol. 38, no. 2, p. 103–112. .
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-
Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methylene chloride
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Substance:
Xanthotoxol (RF-00011114-PAR)
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Additional substance description:
xanthotoxin
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
xanthotoxin - fruit
Composition #11: Traboulsi, AF., El-Haj, S., Tueni, M., Taoubi, K., Nader, NA., Mrad, A. Repellency and toxicity of aromatic plant extracts against the mosquito Culex pipiens molestus (Diptera : Culicidae). pest management science, 2005, vol. 61, no. 6, p. 597–604. DOI: 10.1002/ps.1017.
[
DOI link]
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Plant part:
Flower (as part-nature) (A067B)
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Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
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Substance:
Estragole (RF-00003806-PAR)
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Analytical method code:
GC-MS (F046A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
1.1
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Internal remarks:
estragole - flower
Composition #12: Levorato, Sara., Dominici, Luca., Fatigoni, Cristina., Zadra, Claudia., Pagiotti, Rita., Moretti, Massimo., Villarini, Milena. In vitro toxicity evaluation of estragole-containing preparations derived from Foeniculum vulgare Mill. (fennel) on HepG2 cells. food and chemical toxicology, 2018, vol. 111, p. 616–622. DOI: 10.1016/j.fct.2017.12.014.
[
DOI link]
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
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Substance:
Estragole (RF-00003806-PAR)
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Analytical method code:
GC-MS (F046A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
3.89
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Internal remarks:
estragol - essential oil
Composition #13: Levorato, Sara., Dominici, Luca., Fatigoni, Cristina., Zadra, Claudia., Pagiotti, Rita., Moretti, Massimo., Villarini, Milena. In vitro toxicity evaluation of estragole-containing preparations derived from Foeniculum vulgare Mill. (fennel) on HepG2 cells. food and chemical toxicology, 2018, vol. 111, p. 616–622. DOI: 10.1016/j.fct.2017.12.014.
[
DOI link]
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methylene chloride-methanol
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Substance:
Estragole (RF-00003806-PAR)
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Analytical method code:
GC-MS (F046A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
2.52
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Internal remarks:
estragol - seed
Composition #14: Topuzi, Emine., Madanlar, Nilgun., Erler, Fedai. Chemical composition, toxic and development- and reproduction-inhibiting effects of some essential oils against Tetranychus urticae Koch (Acarina: Tetranychidae) as fumigants. journal of plant diseases and protection, 2018, vol. 125, no. 4, p. 377–387. DOI: 10.1007/s41348-018-0161-9.
[
DOI link]
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
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Additional extraction description:
essential oil yield is 7.8 ml/kg dried plant
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Substance:
Estragole (RF-00003806-PAR)
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Analytical method code:
GC-MS (F046A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
3.99
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Internal remarks:
estragol - seed essential oil
Composition #15: Topuzi, Emine., Madanlar, Nilgun., Erler, Fedai. Chemical composition, toxic and development- and reproduction-inhibiting effects of some essential oils against Tetranychus urticae Koch (Acarina: Tetranychidae) as fumigants. journal of plant diseases and protection, 2018, vol. 125, no. 4, p. 377–387. DOI: 10.1007/s41348-018-0161-9.
[
DOI link]
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
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Additional extraction description:
essential oil yield is 7.8 ml/kg dried plant
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Substance:
fenchone (RF-00003814-PAR)
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Analytical method code:
GC-MS (F046A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
1.97
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Internal remarks:
fenchone - seed essential oil
Endpoint study
#1: Shayan, Maryam., Mehrannia, Kobra., Rastegar, Tayebeh., Khanehzad, Maryam., Ghantabpour, Taha., Hassanzadeh, Gholamreza. Teratogenic effect of the aqueous extract of the Foeniculum vulgare (fennel) on fetal development in mice. journal of contemporary medical sciences, 2019, vol. 5, no. 5, p. 258–263. DOI: 10.22317/jcms.10201905.
[
DOI link]
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Study relevance:
Human health
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Plant part:
Seed (as part-nature) (A066P)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
water extract
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Type of toxicological test:
reproduction toxicity (CHD009TT)
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Tested organism:
House mouse (as animal) (A0CNT)
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Strain of test organism:
Balb/c (CHD002ST)
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Route of exposure:
ORAL: GAVAGE (OECD2231PL)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
6
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligram (G155A)
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Effect concentration:
12.5-25
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Critical effect:
DEVELOPMENTAL (TOX07A)
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Effect description:
embryotoxicity in mice models in morphological, skeletal and cellular levels.
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Effect or parameter linked to the endpoint:
development (CHD006BE)
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Internal remarks:
embryotoxicity in mice models
Genotox #1: Mahmoud, I., Alkofahi, A., Abdelaziz, A. Mutagenic and toxic activities of several spices and some Jordanian medicinal plants. international journal of pharmacognosy, 1992, vol. 30, no. 2, p. 81–85. .
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Study category:
Genotoxicity
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Type of toxicological test:
bacterial gene mutation assay (CHD027TT)
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Tested organism:
Salmonella typhimurium (as organism) (A0CPZ)
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Strain of test organism:
TA 1535, TA 1537, TA 98, TA 100 and TA 102 (CHD039ST)
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Endpoint measured:
DNA damage and/or repair
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Remarks on genotox study:
ethanol extract is intermediate genotox acoording to Ames test on Salmonella typhimurium TA98, TA102
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Internal remarks:
intermediate genotox, Ames test - ethanol extract
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Internal ID:
2-s2.0-0026675463