EFSA Compendium of Botanicals

Draft - work in progress

Ferula hermonis Boiss.

Family:: Apiaceae
Approval state:: Approved
Number of articles retrieved:: 81
Number of processed references:: 3

Compositions

#1: sandrosaponins IX, X, XI in roots #2: daidzein in roots #3: biochanin A in roots

Endpoint Studies

#1: Root extract of Ferula hermonis affected testosterone level, fertility and caused degenerative changes in testis, epididymis, seminal vesicle

Genotoxicity

Composition #1: Ibraheim, Zedan Z., Abdel-Mageed, Wael M., Jaspars, Marcel. Triterpenoid saponins from Ferula hermonis Boiss. biochemical systematics and ecology, 2012, vol. 40, p. 86–90. DOI: 10.1016/j.bse.2011.09.006. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Triterpene saponins Triterpene saponins (RF-00004338-PAR)
Additional substance description:

sandrosaponins IX, X, XI
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, HPLC, TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

sandrosaponins IX, X, XI in roots

Composition #2: Saeed, Ibtesam A., Ali, Lizna., Jabeen, Ayesha., Khasawneh, Mohammad., Rizvi, Tahir A., Ashraf, S. Salman. Estrogenic Activities of Ten Medicinal Herbs from the Middle East. journal of chromatographic science, 2013, vol. 51, no. 1, p. 33–39. DOI: 10.1093/chromsci/bms101. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

daidzein (RF-00000061-NTR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

silica gel chromatography, HPLC
Result unit:

Microgram/gram (G049A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.25-0.33
Internal remarks:

daidzein in roots

Composition #3: Saeed, Ibtesam A., Ali, Lizna., Jabeen, Ayesha., Khasawneh, Mohammad., Rizvi, Tahir A., Ashraf, S. Salman. Estrogenic Activities of Ten Medicinal Herbs from the Middle East. journal of chromatographic science, 2013, vol. 51, no. 1, p. 33–39. DOI: 10.1093/chromsci/bms101. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

biochanin-A (RF-00004182-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

silica gel chromatography, HPLC
Result unit:

Microgram/gram (G049A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.08
Internal remarks:

biochanin A in roots

Endpoint study #1: Ayuob, Nasra N., AL-Harbi, Mohammad S., Abdulhadi, Soad S. Is the chronic use of Ferula harmonis to enhance mice erectile function effective and safe? A histopathological study . systems biology in reproductive medicine, 2014, vol. 60, no. 5, p. 282–292. DOI: 10.3109/19396368.2014.923059. [DOI link]

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

H2O
Type of toxicological test:

reproduction toxicity (CHD009TT)
Limit test:

Not applicable
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

Swiss (CHD005ST)
Sex:

Male
Exposure duration:

6.0
Unit of exposure duration:

Week (G205A)
Number of organisms dosed:

30
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

6
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Testes (TT050A)
Effect description:

F. hermonis extract significantly decreased level of testosterone and partially impaired fertility. Histopathological degenerative changes and significant reduction in estrogen receptor expression observed in testes, epididymis, and seminal vesicle
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

Root extract of Ferula hermonis affected testosterone level, fertility and caused degenerative changes in testis, epididymis, seminal vesicle