EFSA
ecomole
vscht
  2. Eurycoma longifolia Jack

Eurycoma longifolia Jack

Family:
Simaroubaceae
Approval state:
Approved
Number of articles retrieved:
638
Number of processed references:
7
Compositions
#1: Isoscopoletin (coumarin) #2: Eurycomanone (quassinoid) #3: eurycomanol (quassinoid) #4: 13,21-Dihydroeurycomanone (quassinoid) #5: eurycomanol-2-O-beta-glucopyranoside (quassinoid) #6: eurycomanone (RF-00003507-PAR) #7: eurycomanol (RF-00003497-PAR) #8: epoxyeuricomanone #9: 13,21 - dihydroeurycomanone #10: eurycomanone #11: eurycomanol (quassinoid) in roots #12: Quassinoids (eurycomanol-2-O-beta-glucopyranoside and 13,21-Dihydroxyeurocomanone; 14,15 - dihydroxyklaineanone, longilactone) #13: Canthin-6-one alkaloids (16 different substances) #14: beta-Carboline alkaloids (4 different substances) #15: Biphenylneolignans (3 different substances) #16: Eurycomanone in roots #17: Total quassinoids in roots #18: biphenyl neolignans #19: carboline alkaloids #20: saponins #21: Quassinoids #22: Canthin-6-one alkaloids in bark,stem and roots
Endpoint Studies
#1: acute toxicity of 50% water- ethanol extract in mice (1.75-2.05 milligram/kilogram b.w.) #2: eurycomanone LD50 #3: LD50 of the n-butanol extract of the fraction obtained by extraction of root with 50% acqueous ethanol. #4: acute toxicity in the rat-gastric dilatation or bloated stomach #5: Oral LD50 of the alcoholic extract for mice is between 1500 and 2000 mg/kg b.w
Genotoxicity
Composition #1: Nguyen, Thanh Tam., Tran, Thi Phuong Thao., Tran, Van Loc., Ngo, Thi Thuy., Nguyen, Duy Nhu., Tran, Van Sung. About the chemical constituents of the roots of Eurycoma longifolia. tap chi hoa hoc, 2014, vol. 52, no. 1, p. 124–129. .
Composition #2: Ebrahimi Forough., Ibrahim Baharudin., Murugaiyah Vikneswaran., Lam Chan Kit., Teh Chin Hoe. 1HNMR-Based Discriminatory Analysis of Eurycoma longifolia from Different Locations and Establishing a Profile for Primary Metabolites Identification and Quassinoids Quantification. planta medica, 2017, vol. 83(1-02), p. 172–182. .
Composition #3: Ebrahimi Forough., Ibrahim Baharudin., Murugaiyah Vikneswaran., Lam Chan Kit., Teh Chin Hoe. 1HNMR-Based Discriminatory Analysis of Eurycoma longifolia from Different Locations and Establishing a Profile for Primary Metabolites Identification and Quassinoids Quantification. planta medica, 2017, vol. 83(1-02), p. 172–182. .
Composition #4: Ebrahimi Forough., Ibrahim Baharudin., Murugaiyah Vikneswaran., Lam Chan Kit., Teh Chin Hoe. 1HNMR-Based Discriminatory Analysis of Eurycoma longifolia from Different Locations and Establishing a Profile for Primary Metabolites Identification and Quassinoids Quantification. planta medica, 2017, vol. 83(1-02), p. 172–182. .
Composition #5: Ebrahimi Forough., Ibrahim Baharudin., Murugaiyah Vikneswaran., Lam Chan Kit., Teh Chin Hoe. 1HNMR-Based Discriminatory Analysis of Eurycoma longifolia from Different Locations and Establishing a Profile for Primary Metabolites Identification and Quassinoids Quantification. planta medica, 2017, vol. 83(1-02), p. 172–182. .
Composition #6: Tong, Kind Leng., Chan, Kit Lam., AbuBakar, Sazaly., Low, Bin Seng., Ma, Hai Qiu., Wong, Pooi Fong. The in vitro and in vivo anti-cancer activities of a standardized quassinoids composition from Eurycoma longifolia on LNCaP human prostate cancer cells. . plos one, 2015, vol. 10, no. 3, p. e0121752. DOI: 10.1371/journal.pone.0121752. [DOI link]
Composition #7: Tong, Kind Leng., Chan, Kit Lam., AbuBakar, Sazaly., Low, Bin Seng., Ma, Hai Qiu., Wong, Pooi Fong. The in vitro and in vivo anti-cancer activities of a standardized quassinoids composition from Eurycoma longifolia on LNCaP human prostate cancer cells. . plos one, 2015, vol. 10, no. 3, p. e0121752. DOI: 10.1371/journal.pone.0121752. [DOI link]
Composition #8: Tong, Kind Leng., Chan, Kit Lam., AbuBakar, Sazaly., Low, Bin Seng., Ma, Hai Qiu., Wong, Pooi Fong. The in vitro and in vivo anti-cancer activities of a standardized quassinoids composition from Eurycoma longifolia on LNCaP human prostate cancer cells. . plos one, 2015, vol. 10, no. 3, p. e0121752. DOI: 10.1371/journal.pone.0121752. [DOI link]
Composition #9: Tong, Kind Leng., Chan, Kit Lam., AbuBakar, Sazaly., Low, Bin Seng., Ma, Hai Qiu., Wong, Pooi Fong. The in vitro and in vivo anti-cancer activities of a standardized quassinoids composition from Eurycoma longifolia on LNCaP human prostate cancer cells. . plos one, 2015, vol. 10, no. 3, p. e0121752. DOI: 10.1371/journal.pone.0121752. [DOI link]
Composition #10: Chan, KL., Choo, CY. The toxicity of some quassinoids from Eurycoma longifolia. planta medica, 2002, vol. 68, no. 7, p. 662–664. DOI: 10.1055/s-2002-32907. [DOI link]
Composition #11: Chan, KL., Choo, CY. The toxicity of some quassinoids from Eurycoma longifolia. planta medica, 2002, vol. 68, no. 7, p. 662–664. DOI: 10.1055/s-2002-32907. [DOI link]
Composition #12: Chan, KL., Choo, CY. The toxicity of some quassinoids from Eurycoma longifolia. planta medica, 2002, vol. 68, no. 7, p. 662–664. DOI: 10.1055/s-2002-32907. [DOI link]
Composition #13: Chua, Lee Suan., Amin, Nor Amaiza Mohd., Neo, Jason Chun Hong., Lee, Ting Hun., Lee, Chew Tin., Sarmidi, Mohamad Roji., Aziz, Ramlan Abdul. LC-MS/MS-based metabolites of Eurycoma longifolia (Tongkat Ali) in Malaysia (Perak and Pahang) . journal of chromatography b-analytical technologies in the biomedical and life sciences, 2011, vol. 879, no. 32, p. 3909–3919. DOI: 10.1016/j.jchromb.2011.11.002. [DOI link]
Composition #14: Chua, Lee Suan., Amin, Nor Amaiza Mohd., Neo, Jason Chun Hong., Lee, Ting Hun., Lee, Chew Tin., Sarmidi, Mohamad Roji., Aziz, Ramlan Abdul. LC-MS/MS-based metabolites of Eurycoma longifolia (Tongkat Ali) in Malaysia (Perak and Pahang) . journal of chromatography b-analytical technologies in the biomedical and life sciences, 2011, vol. 879, no. 32, p. 3909–3919. DOI: 10.1016/j.jchromb.2011.11.002. [DOI link]
Composition #15: Chua, Lee Suan., Amin, Nor Amaiza Mohd., Neo, Jason Chun Hong., Lee, Ting Hun., Lee, Chew Tin., Sarmidi, Mohamad Roji., Aziz, Ramlan Abdul. LC-MS/MS-based metabolites of Eurycoma longifolia (Tongkat Ali) in Malaysia (Perak and Pahang) . journal of chromatography b-analytical technologies in the biomedical and life sciences, 2011, vol. 879, no. 32, p. 3909–3919. DOI: 10.1016/j.jchromb.2011.11.002. [DOI link]
Composition #16: Low, Bin-Seng., Das, Prashanta Kumar., Chan, Kit-Lam. Acute, Reproductive Toxicity and Two-generation Teratology Studies of a Standardized Quassinoid-rich Extract of Eurycoma longifolia Jack in Sprague-Dawley Rats . phytotherapy research, 2014, vol. 28, no. 7, p. 1022–1029. DOI: 10.1002/ptr.5094. [DOI link]
Composition #17: Low, Bin-Seng., Das, Prashanta Kumar., Chan, Kit-Lam. Acute, Reproductive Toxicity and Two-generation Teratology Studies of a Standardized Quassinoid-rich Extract of Eurycoma longifolia Jack in Sprague-Dawley Rats . phytotherapy research, 2014, vol. 28, no. 7, p. 1022–1029. DOI: 10.1002/ptr.5094. [DOI link]
Composition #18: Rehman, Shaheed Ur., Choe, Kevin., Yoo, Hye Hyun. Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology . molecules, 2016, vol. 21, no. 3 . DOI: 10.3390/molecules21030331. [DOI link]
Composition #19: Rehman, Shaheed Ur., Choe, Kevin., Yoo, Hye Hyun. Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology . molecules, 2016, vol. 21, no. 3 . DOI: 10.3390/molecules21030331. [DOI link]
Composition #20: Rehman, Shaheed Ur., Choe, Kevin., Yoo, Hye Hyun. Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology . molecules, 2016, vol. 21, no. 3 . DOI: 10.3390/molecules21030331. [DOI link]
Composition #21: Rehman, Shaheed Ur., Choe, Kevin., Yoo, Hye Hyun. Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology . molecules, 2016, vol. 21, no. 3 . DOI: 10.3390/molecules21030331. [DOI link]
Composition #22: Rehman, Shaheed Ur., Choe, Kevin., Yoo, Hye Hyun. Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology . molecules, 2016, vol. 21, no. 3 . DOI: 10.3390/molecules21030331. [DOI link]
Endpoint study #1: Chan, KL., Choo, CY. The toxicity of some quassinoids from Eurycoma longifolia. planta medica, 2002, vol. 68, no. 7, p. 662–664. DOI: 10.1055/s-2002-32907. [DOI link]
Endpoint study #2: Chan, KL., Choo, CY. The toxicity of some quassinoids from Eurycoma longifolia. planta medica, 2002, vol. 68, no. 7, p. 662–664. DOI: 10.1055/s-2002-32907. [DOI link]
Endpoint study #3: Chan, KL., Choo, CY. The toxicity of some quassinoids from Eurycoma longifolia. planta medica, 2002, vol. 68, no. 7, p. 662–664. DOI: 10.1055/s-2002-32907. [DOI link]
Endpoint study #4: Low, Bin-Seng., Das, Prashanta Kumar., Chan, Kit-Lam. Acute, Reproductive Toxicity and Two-generation Teratology Studies of a Standardized Quassinoid-rich Extract of Eurycoma longifolia Jack in Sprague-Dawley Rats . phytotherapy research, 2014, vol. 28, no. 7, p. 1022–1029. DOI: 10.1002/ptr.5094. [DOI link]
Endpoint study #5: Rehman, Shaheed Ur., Choe, Kevin., Yoo, Hye Hyun. Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology . molecules, 2016, vol. 21, no. 3 . DOI: 10.3390/molecules21030331. [DOI link]