EFSA Compendium of Botanicals

Draft - work in progress

Eupatorium purpureum L.

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 41
Number of processed references:: 3

Compositions

#1: pyrrolizidine alkaloids in seeds #2: intermedine in roots #3: lycopsamine in roots #4: benzofurans in rhizomes

Endpoint Studies

Genotoxicity

Composition #1: These, Anja., Bodi, Dorina., Ronczka, Stefan., Lahrssen-Wiederholt, Monika., Preiss-Weigert, Angelika. Structural screening by multiple reaction monitoring as a new approach for tandem mass spectrometry: presented for the determination of pyrrolizidine alkaloids in plants. analytical and bioanalytical chemistry, 2013, vol. 405, no. 29, p. 9375–9383. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Pyrrolizidine alkaloids (RF-00000230-TOX)
Additional substance description:

MeOH, formic acid
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.65
Internal remarks:

pyrrolizidine alkaloids in seeds

Composition #2: Avula, Bharathi., Sagi, Satyanarayanaraju., Wang, Yan-Hong., Zweigenbaum, Jerry., Wang, Mei., Khan, Ikhlas A. Characterization and screening of pyrrolizidine alkaloids and N-oxides from botanicals and dietary supplements using UHPLC-high resolution mass spectrometry. food chemistry, 2015, vol. 178, p. 136–148. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol,acetonitrile
Substance:

Intermedine (RF-00000227-TOX)
Analytical method code:

LC-MS-MS (QqQ) (F034A)
Result unit:

Nanogram/gram (G076A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

200
Internal remarks:

intermedine in roots

Composition #3: Avula, Bharathi., Sagi, Satyanarayanaraju., Wang, Yan-Hong., Zweigenbaum, Jerry., Wang, Mei., Khan, Ikhlas A. Characterization and screening of pyrrolizidine alkaloids and N-oxides from botanicals and dietary supplements using UHPLC-high resolution mass spectrometry. food chemistry, 2015, vol. 178, p. 136–148. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol,acetonitrile
Substance:

Lycopsamine (RF-00000228-TOX)
Analytical method code:

LC-MS-MS (QqQ) (F034A)
Result unit:

Nanogram/gram (G076A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

30
Internal remarks:

lycopsamine in roots

Composition #4: Habtemariam, S. Antiinflammatory activity of the antirheumatic herbal drug, gravel root (Eupatorium purpureum): Further biological activities and constituents . phytotherapy research, 2001, vol. 15, no. 8, p. 687–690. DOI: 10.1002/ptr.887. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol absolute
Substance:

Benzofurans (RF-00010791-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR, UV, Ei-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

benzofurans in rhizomes