EFSA Compendium of Botanicals

Draft - work in progress

Epimedium sagittatum (Siebold & Zucc.) Maxim.

Family:: Berberidaceae
Approval state:: Approved
Number of articles retrieved:: 396
Number of processed references:: 1

Compositions

#1: Tannin (unspecified) #2: Alkaloids (unspecified)

Endpoint Studies

#1: The study showed a little depressant activity at the highest dose tested (500 mg/kg)

Genotoxicity

Composition #1: Qureshi, M., Mehjabeen., Noorjahan., Muhammad, S., Siddiqui, F.A., Baig, I., Ahmad, M. Phytochemical and biological assessments on Lipidium meyenii (maca) and Epimidium sagittatum (horny goat weed). pakistan journal of pharmaceutical sciences, 2017, vol. 30, no. 1, p. 29–36. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannin (unspecified)

Composition #2: Qureshi, M., Mehjabeen., Noorjahan., Muhammad, S., Siddiqui, F.A., Baig, I., Ahmad, M. Phytochemical and biological assessments on Lipidium meyenii (maca) and Epimidium sagittatum (horny goat weed). pakistan journal of pharmaceutical sciences, 2017, vol. 30, no. 1, p. 29–36. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids (unspecified)

Endpoint study #1: Qureshi, M., Mehjabeen., Noorjahan., Muhammad, S., Siddiqui, F.A., Baig, I., Ahmad, M. Phytochemical and biological assessments on Lipidium meyenii (maca) and Epimidium sagittatum (horny goat weed). pakistan journal of pharmaceutical sciences, 2017, vol. 30, no. 1, p. 29–36. .

Study relevance:

Human health
Plant part:

Unspecified (A07XD)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

ethanol
Type of toxicological test:

chronic/long term toxicity (CHD004TT)
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

Balb/c (CHD002ST)
Sex:

Male/Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Number of organisms dosed:

35
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

300-500
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

neurologic: Brain (TT034A)
Effect description:

The plant extract showed a little depressant activity at an increased dose of 500mg/kg. The symptoms include disorientation and passivity.
Effect or parameter linked to the endpoint:

behaviour (CHD001BE)
Internal remarks:

The study showed a little depressant activity at the highest dose tested (500 mg/kg)