EFSA
ecomole
vscht
  2. Ecballium elaterium (L.) A.Rich.

Ecballium elaterium (L.) A.Rich.

Family:
Cucurbitaceae
Approval state:
Approved
Number of articles retrieved:
481
Number of processed references:
10
Compositions
#1: cucurbitacines C, D, E, H, I in roots, leaves and fruits #2: Cucurbitacin E (fruit) #3: cucurbitacin B (FRUIT) #4: cucurbitacin D (unspecified) #5: Cucurbitacin D (fruit) #6: Cucurbitacin I (fruit)
Endpoint Studies
#1: nausea vomiting diarrhoea and irritation of skin and mucous tissue #2: redness. tingling, epiphora, blurred vision #3: cholestatic hepatitis, regression of jaundice and pruritus and normalization of liver function
Genotoxicity
#1: genotoxicity activity of fruit extract in COMET assay in Human Lymphocytes #2: genotoxic effects (chromosome aberration) on A. cepa root tip cells.
Composition #1: Rodriguez Gonzalez, B., Martin Panizo, F. Composition of Ecballium elaterium. II. Separation of free cucurbitacins. anales de la real sociedad espanola de fisica y quimica, serie b: quimica, 1967, vol. 63(9-10), p. 959–64. .
Composition #2: Attard, E., Cuschieri, A., Brincat, M.P. Morphological effects induced by Cucurbitacin E on ovarian cancer cells in vitro. journal of natural remedies, 2005, vol. 5, no. 1, p. 70–74. .
Composition #3: Agil, A., Miro, M., Jimenez, J., Aneiros, J., Caracuel, MD., Garcia-Granados, A., Navarro, MC. Isolation of an anti-hepatotoxic principle from the juice of Ecballium elaterium . planta medica, 1999, vol. 65, no. 7, p. 673–675. DOI: 10.1055/s-2006-960847. [DOI link]
Composition #4: Jacquot, Catherine., Rousseau, Benedicte., Carbonnelle, Delphine., Chinou, Ioanna., Malleter, Marine., Tomasoni, Christophe., Roussakis, Christos. Cucurbitacin-D-induced CDK1 mRNA Up-regulation Causes Proliferation Arrest of a Non-small Cell Lung Carcinoma Cell Line (NSCLC-N6) . anticancer research, 2014, vol. 34, no. 9, p. 4797–4806. .
Composition #5: VITERBO, A., YAGEN, B., ROSENTHAL, R., MAYER, AM. DEPENDENCE OF ACTIVITY OF CUCURBITACIN IN REPRESSION OF BOTRYTIS LACCASE ON ITS STRUCTURE . phytochemistry, 1993, vol. 33, no. 6, p. 1313–1315. DOI: 10.1016/0031-9422(93)85081-2. [DOI link]
Composition #6: VITERBO, A., YAGEN, B., ROSENTHAL, R., MAYER, AM. DEPENDENCE OF ACTIVITY OF CUCURBITACIN IN REPRESSION OF BOTRYTIS LACCASE ON ITS STRUCTURE . phytochemistry, 1993, vol. 33, no. 6, p. 1313–1315. DOI: 10.1016/0031-9422(93)85081-2. [DOI link]
Endpoint study #1: Perovic, S., Markulin, M. Poisoning with Ecballium elaterium. paediatria croatica, 1994, vol. 38, no. 1, p. 33–36. .
Endpoint study #2: Kocak, Ibrahim., Karabela, Yunus., Karaman, Mehmet., Kaya, Faruk. Late onset diffuse lamellar keratitis as a result of the toxic effect of Ecballium elaterium herb . journal of refractive surgery, 2006, vol. 22, no. 8, p. 826–827. .
Endpoint study #3: Bizid, Sondes., Sabbah, Meriam., Msakni, Issann., Ben Slimene, Baha., Mohamed, Ghanem., Bouali, Riadh., Ben Abdallah, Hatenn., Abdelli, Nabil. Cholestatic hepatitis due to Ecballium elaterium ingestion. clinics and research in hepatology and gastroenterology, 2015, vol. 39, no. 5, p. E60–E62. DOI: 10.1016/j.clinre.2014.11.004. [DOI link]
Genotox #1: Basaran, A. Ahmet., Yu, Tian-Wei., Plewa, Michael J., Anderson, Diana. An investigation of some Turkish herbal medicines in Salmonella typhimurium and in the COMET assay in human lymphocytes. teratogenesis, carcinogenesis, and mutagenesis, 1996, vol. 16, no. 2, p. 125–138. .
Genotox #2: Celik, T. A., Aslanturk, O. S. INVESTIGATION OF CYTOTOXIC AND GENOTOXIC EFFECTS OF ECBALLIUM ELATERIUM JUICE BASED ON ALLIUM TEST . methods and findings in experimental and clinical pharmacology, 2009, vol. 31, no. 9, p. 591–596. DOI: 10.1358/mf.2009.31.9.1434629. [DOI link]