EFSA Compendium of Botanicals

Draft - work in progress

Duboisia hopwoodii (F.Muell.) F.Muell.

Family:: Solanaceae
Approval state:: Approved
Number of articles retrieved:: 56
Number of processed references:: 6

Compositions

#1: nornicotine - leave - EtOH extr #2: nicotine in leaves #3: anabasine in leaves #4: nornicotine in leaves #5: nornicotine - leaves - whole weight #6: nicotine - leaves - whole weight #7: nicotine - leaves - dry weight #8: nornicotine - leaves - dry weight #9: Nicotine in root (% total alkaolid) #10: Nicotine in leaves (% total alkaolid) #11: Nornicotine in leaves (% total alkaolid) #12: Hyoscyamine in root (% total alkaolid) #13: Nornicotine in root (% total alkaolid) #14: alkaloids #15: Nornicotine in leaves #16: Hyoscyamine in root

Endpoint Studies

Genotoxicity

Composition #1: Hicks, C. S., Le Messurier, H. Preliminary observations on the chemistry and pharmacology of the alkaloids of Duboisia hopwoodii. australian journal of experimental biology and medical science, 1935, vol. 13, p. 175–88. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol extract
Substance:

nornicotine (RF-00011227-PAR)
Analytical method code:

Unspecified (F598A)
Analytical method - additional description:

melting point
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

nornicotine - leave - EtOH extr

Composition #2: Sadgrove, Nicholas John. The Influence of Indigenous Food Procurement Techniques on Populations of Cyanobacteria in pre-European Australia: A Potential Small-scale Water Amelioration Tool . ecohealth, 2009, vol. 6, no. 3, p. 390–403. DOI: 10.1007/s10393-010-0276-3. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water extract
Substance:

Nicotine (RF-0809-001-PPP)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

nicotine in leaves

Composition #3: Sadgrove, Nicholas John. The Influence of Indigenous Food Procurement Techniques on Populations of Cyanobacteria in pre-European Australia: A Potential Small-scale Water Amelioration Tool . ecohealth, 2009, vol. 6, no. 3, p. 390–403. DOI: 10.1007/s10393-010-0276-3. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water extract
Substance:

anabasine (RF-00003682-PAR)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

anabasine in leaves

Composition #4: Sadgrove, Nicholas John. The Influence of Indigenous Food Procurement Techniques on Populations of Cyanobacteria in pre-European Australia: A Potential Small-scale Water Amelioration Tool . ecohealth, 2009, vol. 6, no. 3, p. 390–403. DOI: 10.1007/s10393-010-0276-3. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water extract
Substance:

nornicotine (RF-00011227-PAR)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

nornicotine in leaves

Composition #5: BOTTOMLEY, W., WHITE, DE. THE CHEMISTRY OF WESTERN AUSTRALIAN PLANTS .4. DUBOISIA-HOPWOODII. australian journal of scientific research series a-physical sciences, 1951, vol. 4, no. 1, p. 107–111. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Additional extraction description:

ground leaves distilled
Substance:

nornicotine (RF-00011227-PAR)
Analytical method code:

PTA precipitation (F637A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.3-1.3
Internal remarks:

nornicotine - leaves - whole weight

Composition #6: BOTTOMLEY, W., WHITE, DE. THE CHEMISTRY OF WESTERN AUSTRALIAN PLANTS .4. DUBOISIA-HOPWOODII. australian journal of scientific research series a-physical sciences, 1951, vol. 4, no. 1, p. 107–111. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Additional extraction description:

ground leaves distilled
Substance:

Nicotine (RF-0809-001-PPP)
Analytical method code:

PTA precipitation (F637A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3-4.8
Internal remarks:

nicotine - leaves - whole weight

Composition #7: BOTTOMLEY, W., WHITE, DE. THE CHEMISTRY OF WESTERN AUSTRALIAN PLANTS .4. DUBOISIA-HOPWOODII. australian journal of scientific research series a-physical sciences, 1951, vol. 4, no. 1, p. 107–111. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Additional extraction description:

ground leaves distilled
Substance:

Nicotine (RF-0809-001-PPP)
Analytical method code:

PTA precipitation (F637A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.9-2.1
Internal remarks:

nicotine - leaves - dry weight

Composition #8: BOTTOMLEY, W., WHITE, DE. THE CHEMISTRY OF WESTERN AUSTRALIAN PLANTS .4. DUBOISIA-HOPWOODII. australian journal of scientific research series a-physical sciences, 1951, vol. 4, no. 1, p. 107–111. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Additional extraction description:

ground leaves distilled
Substance:

nornicotine (RF-00011227-PAR)
Analytical method code:

PTA precipitation (F637A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.05-0.6
Internal remarks:

nornicotine - leaves - dry weight

Composition #9: LUANRATANA, O., GRIFFIN, WJ. ALKALOIDS OF DUBOISIA-HOPWOODII. phytochemistry, 1982, vol. 21, no. 2, p. 449–451. DOI: 10.1016/S0031-9422(00)95286-5. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Nicotine (RF-0809-001-PPP)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

19
Internal remarks:

Nicotine in root (% total alkaolid)

Composition #10: LUANRATANA, O., GRIFFIN, WJ. ALKALOIDS OF DUBOISIA-HOPWOODII. phytochemistry, 1982, vol. 21, no. 2, p. 449–451. DOI: 10.1016/S0031-9422(00)95286-5. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Nicotine (RF-0809-001-PPP)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

9-77
Internal remarks:

Nicotine in leaves (% total alkaolid)

Composition #11: LUANRATANA, O., GRIFFIN, WJ. ALKALOIDS OF DUBOISIA-HOPWOODII. phytochemistry, 1982, vol. 21, no. 2, p. 449–451. DOI: 10.1016/S0031-9422(00)95286-5. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

nornicotine (RF-00011227-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

20-86
Internal remarks:

Nornicotine in leaves (% total alkaolid)

Composition #12: LUANRATANA, O., GRIFFIN, WJ. ALKALOIDS OF DUBOISIA-HOPWOODII. phytochemistry, 1982, vol. 21, no. 2, p. 449–451. DOI: 10.1016/S0031-9422(00)95286-5. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Hyoscyamine (RF-00000247-TOX)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

41-56
Internal remarks:

Hyoscyamine in root (% total alkaolid)

Composition #13: LUANRATANA, O., GRIFFIN, WJ. ALKALOIDS OF DUBOISIA-HOPWOODII. phytochemistry, 1982, vol. 21, no. 2, p. 449–451. DOI: 10.1016/S0031-9422(00)95286-5. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

nornicotine (RF-00011227-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

18-48
Internal remarks:

Nornicotine in root (% total alkaolid)

Composition #14: WATSON, PL., LUANRATANA, O., GRIFFIN, WJ. THE ETHNOPHARMACOLOGY OF PITURI. journal of ethnopharmacology, 1983, vol. 8, no. 3, p. 303–311. DOI: 10.1016/0378-8741(83)90067-3. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol extract
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

metanicotine. Anatabine Cotinine N-formylnornicotine
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

alkaloids

Composition #15: ENDO, T., YAMADA, Y. ALKALOID PRODUCTION IN CULTURED ROOTS OF 3 SPECIES OF DUBOISIA. phytochemistry, 1985, vol. 24, no. 6, p. 1233–1236. DOI: 10.1016/S0031-9422(00)81107-3. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Substance:

nornicotine (RF-00011227-PAR)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Nornicotine in leaves

Composition #16: ENDO, T., YAMADA, Y. ALKALOID PRODUCTION IN CULTURED ROOTS OF 3 SPECIES OF DUBOISIA. phytochemistry, 1985, vol. 24, no. 6, p. 1233–1236. DOI: 10.1016/S0031-9422(00)81107-3. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Substance:

Hyoscyamine (RF-00000247-TOX)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Hyoscyamine in root