EFSA Compendium of Botanicals

Draft - work in progress

Dimorphandra mollis Benth.

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 172
Number of processed references:: 3

Compositions

#1: gallic acid esters, leaves, paper chromatography #2: gallic acid, bark, paper chromatography #3: gallic acid, leaves, paper chromatography #4: gallic acid esters, bark, paper chromatography #5: Proanthocyanidins, leaves, colorimetry #6: Proanthocyanidins, bark, colorimetry

Endpoint Studies

#1: colic, polyuria, oliguria, hematuria and death within 24 hours #2: abortion in the final third of pregnancy (26 cases), edema, diarrhea, incoordination, apathy and lack of appetite

Genotoxicity

Composition #1: Santos, SC., Costa, WF., Ribeiro, JP., Guimaraes, DO., Ferri, PH., Ferreira, HD., Seraphin, JC. Tannin composition of barbatimao species. fitoterapia, 2002, vol. 73, no. 4, p. 292–299. DOI: 10.1016/S0367-326X(02)00081-3. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

aceton and water
Substance:

gallic acid (RF-00003821-PAR)
Additional substance description:

esters
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

colorimetry
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

51.6
Internal remarks:

gallic acid esters, leaves, paper chromatography

Composition #2: Santos, SC., Costa, WF., Ribeiro, JP., Guimaraes, DO., Ferri, PH., Ferreira, HD., Seraphin, JC. Tannin composition of barbatimao species. fitoterapia, 2002, vol. 73, no. 4, p. 292–299. DOI: 10.1016/S0367-326X(02)00081-3. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

aceton and water
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

colorimetry
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

gallic acid, bark, paper chromatography

Composition #3: Santos, SC., Costa, WF., Ribeiro, JP., Guimaraes, DO., Ferri, PH., Ferreira, HD., Seraphin, JC. Tannin composition of barbatimao species. fitoterapia, 2002, vol. 73, no. 4, p. 292–299. DOI: 10.1016/S0367-326X(02)00081-3. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

aceton and water
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

colorimetry
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

gallic acid, leaves, paper chromatography

Composition #4: Santos, SC., Costa, WF., Ribeiro, JP., Guimaraes, DO., Ferri, PH., Ferreira, HD., Seraphin, JC. Tannin composition of barbatimao species. fitoterapia, 2002, vol. 73, no. 4, p. 292–299. DOI: 10.1016/S0367-326X(02)00081-3. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

aceton and water
Substance:

gallic acid (RF-00003821-PAR)
Additional substance description:

esters
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

colorimetry
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

36.9
Internal remarks:

gallic acid esters, bark, paper chromatography

Composition #5: Santos, SC., Costa, WF., Ribeiro, JP., Guimaraes, DO., Ferri, PH., Ferreira, HD., Seraphin, JC. Tannin composition of barbatimao species. fitoterapia, 2002, vol. 73, no. 4, p. 292–299. DOI: 10.1016/S0367-326X(02)00081-3. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

aceton and water
Substance:

Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

colorimetry
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

33
Internal remarks:

Proanthocyanidins, leaves, colorimetry

Composition #6: Santos, SC., Costa, WF., Ribeiro, JP., Guimaraes, DO., Ferri, PH., Ferreira, HD., Seraphin, JC. Tannin composition of barbatimao species. fitoterapia, 2002, vol. 73, no. 4, p. 292–299. DOI: 10.1016/S0367-326X(02)00081-3. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

aceton and water
Substance:

Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

colorimetry
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

269.7
Internal remarks:

Proanthocyanidins, bark, colorimetry

Endpoint study #1: Costa, A.M.D., De Souza, D.P.M., Cavalcante, T.V., De Araújo, V.L., Ramos, A.T., Maruo, V.M. Poisonous plants of livestock interest in the Amazonia and Savanna ecotone region Part II: Araguaína, North of Tocantins state, Brazil Plantas tóxicas de interesse pecuário em região de ecótono amazônia e cerrado. parte ii: araguaína, norte do tocantins . acta veterinaria brasilica, 2011, vol. 5, no. 3, p. 317–324. .

Study relevance:

Animal (target species) health
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Cattle (as animal) (A057E)
Route of exposure:

ORAL: FEED (OECD2230PL)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEPHROTOXICITY (TOX03A)
Target tissue:

Urogenital (TT006A)
Effect description:

colic, polyuria, oliguria, hematuria and death within 24 hours
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

colic, polyuria, oliguria, hematuria and death within 24 hours

Endpoint study #2: Ferreira de Sant'Ana, Fabiano Jose., Reis Junior, Janildo Ludolf., Freitas Neto, Argemiro Pereira., Moreira Junior, Carlos Alberto., Scalla Vulcani, Valcinir Aloisio., Rabelo, Rogerio Elias., Terra, Juliano Pereira. Toxic plants for ruminants in Southwestern Goias, Brazil. ciencia rural, 2014, vol. 44, no. 5, p. 865–871. .

Study relevance:

Animal (target species) health
Plant part:

Seed (as part-nature) (A066P)
Additional plant/substance description:

BEANS
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Cattle (as animal) (A057E)
Sex:

Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Number of organisms dosed:

28
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

Urogenital (TT006A)
Effect description:

abortion in the final third of pregnancy, subcutaneous perineal and abdominal edema, diarrhea, incoordination, apathy and lack of appetite
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

abortion in the final third of pregnancy (26 cases), edema, diarrhea, incoordination, apathy and lack of appetite