EFSA
ecomole
vscht
  2. Dictamnus albus L. // Dictamnus albus subsp. caucasicus (Fisch. & C.A.Mey.) N.A.Winter // Dictamnus angustifolius G.Don ex Sweet

Dictamnus albus L. // Dictamnus albus subsp. caucasicus (Fisch. & C.A.Mey.) N.A.Winter // Dictamnus angustifolius G.Don ex Sweet

Family:
Rutaceae
Approval state:
Approved
Number of articles retrieved:
569
Number of processed references:
14
Compositions
#1: Gamma fagarine in root (bark) #2: Dictamnine in root (bark) #3: Furoquinoline alkaloids (dictamine, dictangustine-A, iso-gamma-fagarine, isodictamin, isomaculosidine and preskimmianine) in root (bark) #4: Gamma fagarine (furoquinoline alkaloid) in root (bark) #5: Angustifoline in root (bark) #6: Herniarin in root (bark) #7: Dictamnine (dictamine) in root (bark) #8: Scopoletin in root (bark) #9: Skimmianine (furoquinoline alkaloid) in root (bark) #10: Umbelliferone in root (bark) #11: Isodictamdiol (a limonoid) (root) #12: 8-Hydroxy-9-methyl-furo[2, 3-b]quinolin-4(9H)-one (root) #13: dictamdiol (a limonoid) (root) #14: Anstifolines A and B (root bark) #15: 5-methoxylrobustine (root) #16: Robustine (root) #17: Isopteleine (root) #18: Bergapten (5‐methoxypsoralen) (stems, leaves and flower) #19: 8‐methoxypsoralen (stems, leaves and flower) #20: Dictamnine (roots) #21: Obacunone (root bark) #22: Skimmianine (aerial part) #23: Auraptene (aerial part) #24: Umbelliferone (aerial part) #25: Xanthotoxin (aerial part) #26: Coumarin 7-(6'R-hydroxy-3', 7'-dimethyl-2'E, 7'-octadienyloxy) (aerial part) #27: fraxinellone (root bark) #28: Dictamnine (root) #29: Dictamnine derivative: 5-methoxydictamnine (root) #30: sonminine (root) #31: isopteleine (root) #32: Isodictamnine (root) #33: haplopine (root) #34: 5-hydroxy-4,8-dimethoxy-furoquinoline (root) #35: Gamma fagarine (root bark) #36: Dictamnine (root bark) #37: Skimmianine (root bark)
Endpoint Studies
#1: Liver injury (symptoms: jaundice and general weakness)
Genotoxicity
#1: The methanol extract of the root bark showed mutagenic activity in Salmonella typhimurium TA100 and TA98. #2: Dictamnine was mutagenic in Salmonella typhimurium with metabolic activation (S9) #3: Furoquinoline alkaloids were mutagenicty activity in Salmonella typhimurium TA 100 with S9 activation
Composition #1: Mizuta, Mari., Kanamori, Hisayuki. Mutagenic activities of dictamnine and γ-fagarine from Dictamni radicis cortex (Rutaceae). mutation research letters, 1985, vol. 144, no. 4, p. 221–5. .
Composition #2: Mizuta, Mari., Kanamori, Hisayuki. Mutagenic activities of dictamnine and γ-fagarine from Dictamni radicis cortex (Rutaceae). mutation research letters, 1985, vol. 144, no. 4, p. 221–5. .
Composition #3: Wu, Tian-Shung., Li, Chia-Ying., Leu, Yann-Lii., Hu, Chang-Qi. Limonoids and alkaloids of the root bark of Dictamnus angustifolius. phytochemistry, 1998, vol. 1999, 50, no. 3, p. 509–512. .
Composition #4: Wu, Tian-Shung., Li, Chia-Ying., Leu, Yann-Lii., Hu, Chang-Qi. Limonoids and alkaloids of the root bark of Dictamnus angustifolius. phytochemistry, 1998, vol. 1999, 50, no. 3, p. 509–512. .
Composition #5: Wu, Tian-Shung., Li, Chia-Ying., Leu, Yann-Lii., Hu, Chang-Qi. Limonoids and alkaloids of the root bark of Dictamnus angustifolius. phytochemistry, 1998, vol. 1999, 50, no. 3, p. 509–512. .
Composition #6: Wu, Tian-Shung., Li, Chia-Ying., Leu, Yann-Lii., Hu, Chang-Qi. Limonoids and alkaloids of the root bark of Dictamnus angustifolius. phytochemistry, 1998, vol. 1999, 50, no. 3, p. 509–512. .
Composition #7: Wu, Tian-Shung., Li, Chia-Ying., Leu, Yann-Lii., Hu, Chang-Qi. Limonoids and alkaloids of the root bark of Dictamnus angustifolius. phytochemistry, 1998, vol. 1999, 50, no. 3, p. 509–512. .
Composition #8: Wu, Tian-Shung., Li, Chia-Ying., Leu, Yann-Lii., Hu, Chang-Qi. Limonoids and alkaloids of the root bark of Dictamnus angustifolius. phytochemistry, 1998, vol. 1999, 50, no. 3, p. 509–512. .
Composition #9: Wu, Tian-Shung., Li, Chia-Ying., Leu, Yann-Lii., Hu, Chang-Qi. Limonoids and alkaloids of the root bark of Dictamnus angustifolius. phytochemistry, 1998, vol. 1999, 50, no. 3, p. 509–512. .
Composition #10: Wu, Tian-Shung., Li, Chia-Ying., Leu, Yann-Lii., Hu, Chang-Qi. Limonoids and alkaloids of the root bark of Dictamnus angustifolius. phytochemistry, 1998, vol. 1999, 50, no. 3, p. 509–512. .
Composition #11: Sun, Jian-Bo., Qu, Wei., Wang, Pei., Wu, Fei-Hua., Wang, Li-Ying., Liang, Jing-Yu. Degraded limonoids and quinoline alkaloids from Dictamnus angustifolius G. Don ex Sweet. and their anti-platelet aggregation activity. fitoterapia, 2013, vol. 90, p. 209–213. .
Composition #12: Sun, Jian-Bo., Qu, Wei., Wang, Pei., Wu, Fei-Hua., Wang, Li-Ying., Liang, Jing-Yu. Degraded limonoids and quinoline alkaloids from Dictamnus angustifolius G. Don ex Sweet. and their anti-platelet aggregation activity. fitoterapia, 2013, vol. 90, p. 209–213. .
Composition #13: Sun, Jian-Bo., Qu, Wei., Wang, Pei., Wu, Fei-Hua., Wang, Li-Ying., Liang, Jing-Yu. Degraded limonoids and quinoline alkaloids from Dictamnus angustifolius G. Don ex Sweet. and their anti-platelet aggregation activity. fitoterapia, 2013, vol. 90, p. 209–213. .
Composition #14: Sun, Jianbo., Jiang, Neng., Lv, Mengying., Tang, Benqin., Wang, Pei., Liang, Jingyu., Chen, Li. Anstifolines A and B, two dimeric furoquinoline alkaloids from the root bark of Dictamnus angustifolius. rsc advances, 2016, vol. 6, no. 27, p. 22550–22554. .
Composition #15: Sun, Jian-bo., Qu, Wei., Guan, Fu-qin., Li, Lin-zhen., Liang, Jing-yu. A new quinoline alkaloid from the roots of Dictamnus angustifolius. zhongguo tianran yaowu, 2014, vol. 12, no. 3, p. 222–224. .
Composition #16: Sun, Jian-bo., Qu, Wei., Guan, Fu-qin., Li, Lin-zhen., Liang, Jing-yu. A new quinoline alkaloid from the roots of Dictamnus angustifolius. zhongguo tianran yaowu, 2014, vol. 12, no. 3, p. 222–224. .
Composition #17: Sun, Jian-bo., Qu, Wei., Guan, Fu-qin., Li, Lin-zhen., Liang, Jing-yu. A new quinoline alkaloid from the roots of Dictamnus angustifolius. zhongguo tianran yaowu, 2014, vol. 12, no. 3, p. 222–224. .
Composition #18: Möller, H. Phototoxicity of Dictamnus alba. contact dermatitis, 1978, vol. 4, no. 5, p. 264–269. DOI: 10.1111/j.1600-0536.1978.tb04556.x. [DOI link]
Composition #19: Möller, H. Phototoxicity of Dictamnus alba. contact dermatitis, 1978, vol. 4, no. 5, p. 264–269. DOI: 10.1111/j.1600-0536.1978.tb04556.x. [DOI link]
Composition #20: Klier, B., Schimmer, O. Microsomal metabolism of dictamnine: identification of metabolites and evaluation of their mutagenicity in Salmonella typhimurium . mutagenesis, 1999, vol. 14, no. 2, p. 181–185. DOI: 10.1093/mutage/14.2.181. [DOI link]
Composition #21: Jung, HJ., Sok, DE., Kim, YH., Min, BS., Lee, JP., Bae, KH. Potentiating effect of obacunone from Dictamnus dasycarpus on cytotoxicity of microtuble inhibitors, vincristine, vinblastine and taxol . planta medica, 2000, vol. 66, no. 1, p. 74–76. .
Composition #22: Jeong, Seon Hwa., Han, Xiang Hua., Hong, Seong Su., Hwang, Ji Sang., Hwang, Ji Hye., Lee, Dongho., Lee, Myung Koo., Ro, Jai Seup., Hwang, Bang Yeon. Monoamine oxidase inhibitory coumarins from the aerial parts of Dictamnus albus . archives of pharmacal research, 2006, vol. 29, no. 12, p. 1119–1124. DOI: 10.1007/BF02969302. [DOI link]
Composition #23: Jeong, Seon Hwa., Han, Xiang Hua., Hong, Seong Su., Hwang, Ji Sang., Hwang, Ji Hye., Lee, Dongho., Lee, Myung Koo., Ro, Jai Seup., Hwang, Bang Yeon. Monoamine oxidase inhibitory coumarins from the aerial parts of Dictamnus albus . archives of pharmacal research, 2006, vol. 29, no. 12, p. 1119–1124. DOI: 10.1007/BF02969302. [DOI link]
Composition #24: Jeong, Seon Hwa., Han, Xiang Hua., Hong, Seong Su., Hwang, Ji Sang., Hwang, Ji Hye., Lee, Dongho., Lee, Myung Koo., Ro, Jai Seup., Hwang, Bang Yeon. Monoamine oxidase inhibitory coumarins from the aerial parts of Dictamnus albus . archives of pharmacal research, 2006, vol. 29, no. 12, p. 1119–1124. DOI: 10.1007/BF02969302. [DOI link]
Composition #25: Jeong, Seon Hwa., Han, Xiang Hua., Hong, Seong Su., Hwang, Ji Sang., Hwang, Ji Hye., Lee, Dongho., Lee, Myung Koo., Ro, Jai Seup., Hwang, Bang Yeon. Monoamine oxidase inhibitory coumarins from the aerial parts of Dictamnus albus . archives of pharmacal research, 2006, vol. 29, no. 12, p. 1119–1124. DOI: 10.1007/BF02969302. [DOI link]
Composition #26: Jeong, Seon Hwa., Han, Xiang Hua., Hong, Seong Su., Hwang, Ji Sang., Hwang, Ji Hye., Lee, Dongho., Lee, Myung Koo., Ro, Jai Seup., Hwang, Bang Yeon. Monoamine oxidase inhibitory coumarins from the aerial parts of Dictamnus albus . archives of pharmacal research, 2006, vol. 29, no. 12, p. 1119–1124. DOI: 10.1007/BF02969302. [DOI link]
Composition #27: Wang, Daijie., Lin, Yunliang., Lin, Xiaojing., Geng, Yanling., Wang, Xiao., Zhang, Jinjie., Qiu, Jiying. EXTRACTION AND ISOLATION OF DICTAMNINE, OBACUNONE AND FRAXINELLONE FROM Dictamnus dasycarpus TURCZ. BY SUPERCRITICAL FLUID EXTRACTION AND HIGH-SPEED COUNTER-CURRENT CHROMATOGRAPHY . quimica nova, 2012, vol. 35, no. 2, p. 337–340. .
Composition #28: Zou, Pingping., Tu, Pengfei., Jiang, Yong. A simple and specific quantitative method for determination of dictamnine in Dictamni Cortex by H-1 NMR spectroscopy . analytical methods, 2013, vol. 5, no. 4, p. 1062–1067. DOI: 10.1039/c2ay26226f. [DOI link]
Composition #29: Sun, Jian-Bo., Qu, Wei., Xiong, Yan., Liang, Jing-Yu. Quinoline alkaloids and sesquiterpenes from the roots of Dictamnus angustifolius . biochemical systematics and ecology, 2013, vol. 50, p. 62–64. DOI: 10.1016/j.bse.2013.03.036. [DOI link]
Composition #30: Sun, Jian-Bo., Qu, Wei., Xiong, Yan., Liang, Jing-Yu. Quinoline alkaloids and sesquiterpenes from the roots of Dictamnus angustifolius . biochemical systematics and ecology, 2013, vol. 50, p. 62–64. DOI: 10.1016/j.bse.2013.03.036. [DOI link]
Composition #31: Sun, Jian-Bo., Qu, Wei., Xiong, Yan., Liang, Jing-Yu. Quinoline alkaloids and sesquiterpenes from the roots of Dictamnus angustifolius . biochemical systematics and ecology, 2013, vol. 50, p. 62–64. DOI: 10.1016/j.bse.2013.03.036. [DOI link]
Composition #32: Sun, Jian-Bo., Qu, Wei., Xiong, Yan., Liang, Jing-Yu. Quinoline alkaloids and sesquiterpenes from the roots of Dictamnus angustifolius . biochemical systematics and ecology, 2013, vol. 50, p. 62–64. DOI: 10.1016/j.bse.2013.03.036. [DOI link]
Composition #33: Sun, Jian-Bo., Qu, Wei., Xiong, Yan., Liang, Jing-Yu. Quinoline alkaloids and sesquiterpenes from the roots of Dictamnus angustifolius . biochemical systematics and ecology, 2013, vol. 50, p. 62–64. DOI: 10.1016/j.bse.2013.03.036. [DOI link]
Composition #34: Sun, Jian-Bo., Qu, Wei., Xiong, Yan., Liang, Jing-Yu. Quinoline alkaloids and sesquiterpenes from the roots of Dictamnus angustifolius . biochemical systematics and ecology, 2013, vol. 50, p. 62–64. DOI: 10.1016/j.bse.2013.03.036. [DOI link]
Composition #35: KANAMORI, H., SAKAMOTO, I., MIZUTA, M. FURTHER STUDY ON MUTAGENIC FUROQUINOLINE ALKALOIDS OF DICTAMNI RADICIS CORTEX - ISOLATION OF SKIMMIANINE AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS . chemical & pharmaceutical bulletin, 1986, vol. 34, no. 4, p. 1826–1829. .
Composition #36: KANAMORI, H., SAKAMOTO, I., MIZUTA, M. FURTHER STUDY ON MUTAGENIC FUROQUINOLINE ALKALOIDS OF DICTAMNI RADICIS CORTEX - ISOLATION OF SKIMMIANINE AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS . chemical & pharmaceutical bulletin, 1986, vol. 34, no. 4, p. 1826–1829. .
Composition #37: KANAMORI, H., SAKAMOTO, I., MIZUTA, M. FURTHER STUDY ON MUTAGENIC FUROQUINOLINE ALKALOIDS OF DICTAMNI RADICIS CORTEX - ISOLATION OF SKIMMIANINE AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS . chemical & pharmaceutical bulletin, 1986, vol. 34, no. 4, p. 1826–1829. .
Endpoint study #1: 장종순., 서의근., 한철., 채희복., 김순제., 이재동., 왕준호. Four cases of toxic liver injury associated with Dictamnus dasycarpus. clinical and molecular hepatology, 2008, vol. 14, no. 2, p. 206–212. .
Genotox #1: Mizuta, Mari., Kanamori, Hisayuki. Mutagenic activities of dictamnine and γ-fagarine from Dictamni radicis cortex (Rutaceae). mutation research letters, 1985, vol. 144, no. 4, p. 221–5. .
Genotox #2: Klier, B., Schimmer, O. Microsomal metabolism of dictamnine: identification of metabolites and evaluation of their mutagenicity in Salmonella typhimurium . mutagenesis, 1999, vol. 14, no. 2, p. 181–185. DOI: 10.1093/mutage/14.2.181. [DOI link]
Genotox #3: KANAMORI, H., SAKAMOTO, I., MIZUTA, M. FURTHER STUDY ON MUTAGENIC FUROQUINOLINE ALKALOIDS OF DICTAMNI RADICIS CORTEX - ISOLATION OF SKIMMIANINE AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS . chemical & pharmaceutical bulletin, 1986, vol. 34, no. 4, p. 1826–1829. .