EFSA Compendium of Botanicals

Draft - work in progress

Daphne laureola L.

Family:: Thymelaeaceae
Approval state:: Approved
Number of articles retrieved:: 75
Number of processed references:: 4

Compositions

#1: Violaxanthin (buds) #2: Coumarin glucosides (leaves) #3: Coumarin glucosides (leaves) #4: Coumarin glucosides (leaves) #5: Coumarin glycosides

Endpoint Studies

#1: Nephrotoxicity of fruits

Genotoxicity

Composition #1: Garcia-Plazaola, Jose I., Hormaetxe, Koldobika., Hernandez, Antonio., Olano, Jose M., Becerril, Jose M. The lutein epoxide cycle in vegetative buds of woody plants. functional plant biology, 2004, vol. 31, no. 8, p. 815–823. .

Language:

English (en)
Plant part:

Bud (as part-nature) (A066Z)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Unspecified in the text but reference given
Substance:

Violaxanthin (RF-00013331-PAR)
Substance used for equivalence:

Chlorophyll a (RF-00010045-PAR)
Analytical method code:

Unspecified (F598A)
Analytical method - additional description:

Unspecified but reference given
Result unit:

Millimole (G115A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

45
Internal remarks:

Violaxanthin (buds)

Composition #2: Alonso, C., Perez, R., Nieto, PM., Delgado, J. Gender dimorphism and altitudinal variation of secondary compounds in leaves of the gynodioecious shrub Daphne laureola . journal of chemical ecology, 2005, vol. 31, no. 1, p. 139–150. DOI: 10.1007/s10886-005-0980-6. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

80% Methanol
Substance:

Coumarin glycosides Coumarin glycosides (RF-00000810-VET)
Additional substance description:

5-O-β−D-glucosyl-(6←1)-β-glucosyl)-7-methoxy-8-hydroxycoumarin
Substance used for equivalence:

Esculetin (RF-00003667-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

ppm (G288A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6221-14585
Internal remarks:

Coumarin glucosides (leaves)

Composition #3: Alonso, C., Perez, R., Nieto, PM., Delgado, J. Gender dimorphism and altitudinal variation of secondary compounds in leaves of the gynodioecious shrub Daphne laureola . journal of chemical ecology, 2005, vol. 31, no. 1, p. 139–150. DOI: 10.1007/s10886-005-0980-6. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

80% Methanol
Substance:

Coumarin glycosides Coumarin glycosides (RF-00000810-VET)
Additional substance description:

5-hydroxy-7-methoxy-8-O-β−D-glucosylcoumarin
Substance used for equivalence:

Esculetin (RF-00003667-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

ppm (G288A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

12153-23727
Internal remarks:

Coumarin glucosides (leaves)

Composition #4: Alonso, C., Perez, R., Nieto, PM., Delgado, J. Gender dimorphism and altitudinal variation of secondary compounds in leaves of the gynodioecious shrub Daphne laureola . journal of chemical ecology, 2005, vol. 31, no. 1, p. 139–150. DOI: 10.1007/s10886-005-0980-6. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

80% Methanol
Substance:

Coumarin glycosides Coumarin glycosides (RF-00000810-VET)
Additional substance description:

5-O-β−D-glucosyl-7-methoxy-8-hydroxycoumarin
Substance used for equivalence:

Esculetin (RF-00003667-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

ppm (G288A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

37292-72584
Internal remarks:

Coumarin glucosides (leaves)

Composition #5: Alonso, Conchita., Garcia, Isabel M., Zapata, Nelson., Perez, Ricardo. Variability in the behavioural responses of three generalist herbivores to the most abundant coumarin in Daphne laureola leaves . entomologia experimentalis et applicata, 2009, vol. 132, no. 1, p. 76–83. DOI: 10.1111/j.1570-7458.2009.00869.x. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

80 % methanol
Substance:

Coumarin glycosides Coumarin glycosides (RF-00000810-VET)
Additional substance description:

5-O-beta-D-glucosyl-7-methoxy-8-hydroxy coumarin
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarin glycosides

Endpoint study #1: Fourasté, I. Reminder on the toxicity of some plants Rappel de la toxicité de quelques plantes . actualites pharmaceutiques, 2004, no. 432, p. 16–19. .

Study relevance:

Human health
Plant part:

Fruit unspecified (as part-nature) (A067D)
Preparation/Extraction method:

Raw, no heat treatment (A07HS)
Type of toxicological test:

acute toxicity (CHD016TT)
Limit test:

No
Tested organism:

Human (as organism) (A056J)
Sex:

No data
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEPHROTOXICITY (TOX03A)
Target tissue:

urogenital: Kidneys (TT046A)
Effect description:

Serious nephrotoxic effects
Effect or parameter linked to the endpoint:

not reported (CHD030BE)
Internal remarks:

Nephrotoxicity of fruits