EFSA
ecomole
vscht
  2. Cynoglossum officinale L.

Cynoglossum officinale L.

Family:
Boraginaceae
Approval state:
Approved
Number of articles retrieved:
378
Number of processed references:
7
Compositions
#1: Pyrrolizidine alkaloids #2: Pyrrolizidine alkaloids (flowers) #3: Pyrrolizidine alkaloids (leaves) #4: Heliosupine (leaves) #5: Heliosupine (flowers) #6: Pyrrolizidine alkaloids #7: Pyrrolizidine alkaloids (flowers and buds) #8: Pyrrolizidine alkaloids (pods) #9: Pyrrolizidine alkaloids (leaves) #10: Pyrrolizidine alkaloids (stem) #11: Pyrrolizidine alkaloids (leaves) #12: Pyrrolizidine alkaloids (Flowers) #13: Pyrrolizidine alkaloids (Fruit) #14: Pyrrolizidine alkaloids (Root) #15: Pyrrolizidine alkaloids (Stem)
Endpoint Studies
#1: Mortality in horses after feeding on dried grass hay containing Cynoglossum officinale. #2: Liver fibrosis and biliary hyperplasia in a pony #3: Mortality in calf after feeding on hay contaminated by this plant #4: Hepatotoxicity in horse
Genotoxicity
Composition #1: van de Schans, M.G.M., Blokland, M.H., Zoontjes, P.W., Mulder, P.P.J., Nielen, M.W.F. Multiple heart-cutting two dimensional liquid chromatography quadrupole time-of-flight mass spectrometry of pyrrolizidine alkaloids. journal of chromatography a, 2017, vol. 1503, p. 38–48. DOI: 10.1016/j.chroma.2017.04.059. [DOI link]
Composition #2: Mudge, Elizabeth M., Jones, A. Maxwell P., Brown, Paula N. Quantification of pyrrolizidine alkaloids in North American plants and honey by LC-MS: single laboratory validation . food additives and contaminants part a-chemistry analysis control exposure & risk assessment, 2015, vol. 32, no. 12, p. 2068–2074. DOI: 10.1080/19440049.2015.1099743. [DOI link]
Composition #3: Mudge, Elizabeth M., Jones, A. Maxwell P., Brown, Paula N. Quantification of pyrrolizidine alkaloids in North American plants and honey by LC-MS: single laboratory validation . food additives and contaminants part a-chemistry analysis control exposure & risk assessment, 2015, vol. 32, no. 12, p. 2068–2074. DOI: 10.1080/19440049.2015.1099743. [DOI link]
Composition #4: Mudge, Elizabeth M., Jones, A. Maxwell P., Brown, Paula N. Quantification of pyrrolizidine alkaloids in North American plants and honey by LC-MS: single laboratory validation . food additives and contaminants part a-chemistry analysis control exposure & risk assessment, 2015, vol. 32, no. 12, p. 2068–2074. DOI: 10.1080/19440049.2015.1099743. [DOI link]
Composition #5: Mudge, Elizabeth M., Jones, A. Maxwell P., Brown, Paula N. Quantification of pyrrolizidine alkaloids in North American plants and honey by LC-MS: single laboratory validation . food additives and contaminants part a-chemistry analysis control exposure & risk assessment, 2015, vol. 32, no. 12, p. 2068–2074. DOI: 10.1080/19440049.2015.1099743. [DOI link]
Composition #6: KNIGHT, AP., KIMBERLING, CV., STERMITZ, FR., ROBY, MR. CYNOGLOSSUM-OFFICINALE (HOUNDS-TONGUE) - A CAUSE OF PYRROLIZIDINE ALKALOID POISONING IN HORSES . journal of the american veterinary medical association, 1984, vol. 185, no. 6, p. 647–650. .
Composition #7: PFISTER, JA., MOLYNEUX, RJ., BAKER, DC. PYRROLIZIDINE ALKALOID CONTENT OF HOUNDSTONGUE (CYNOGLOSSUM-OFFICINALE L) . journal of range management, 1992, vol. 45, no. 3, p. 254–256. DOI: 10.2307/4002973. [DOI link]
Composition #8: PFISTER, JA., MOLYNEUX, RJ., BAKER, DC. PYRROLIZIDINE ALKALOID CONTENT OF HOUNDSTONGUE (CYNOGLOSSUM-OFFICINALE L) . journal of range management, 1992, vol. 45, no. 3, p. 254–256. DOI: 10.2307/4002973. [DOI link]
Composition #9: PFISTER, JA., MOLYNEUX, RJ., BAKER, DC. PYRROLIZIDINE ALKALOID CONTENT OF HOUNDSTONGUE (CYNOGLOSSUM-OFFICINALE L) . journal of range management, 1992, vol. 45, no. 3, p. 254–256. DOI: 10.2307/4002973. [DOI link]
Composition #10: PFISTER, JA., MOLYNEUX, RJ., BAKER, DC. PYRROLIZIDINE ALKALOID CONTENT OF HOUNDSTONGUE (CYNOGLOSSUM-OFFICINALE L) . journal of range management, 1992, vol. 45, no. 3, p. 254–256. DOI: 10.2307/4002973. [DOI link]
Composition #11: ElShazly, A., Sarg, T., Ateya, A., Aziz, EA., Witte, L., Wink, M. Pyrrolizidine alkaloids of Cynoglossum officinale and Cynoglossum amabile (family Boraginaceae) . biochemical systematics and ecology, 1996, vol. 24, no. 5, p. 415–421. DOI: 10.1016/0305-1978(96)00035-X. [DOI link]
Composition #12: ElShazly, A., Sarg, T., Ateya, A., Aziz, EA., Witte, L., Wink, M. Pyrrolizidine alkaloids of Cynoglossum officinale and Cynoglossum amabile (family Boraginaceae) . biochemical systematics and ecology, 1996, vol. 24, no. 5, p. 415–421. DOI: 10.1016/0305-1978(96)00035-X. [DOI link]
Composition #13: ElShazly, A., Sarg, T., Ateya, A., Aziz, EA., Witte, L., Wink, M. Pyrrolizidine alkaloids of Cynoglossum officinale and Cynoglossum amabile (family Boraginaceae) . biochemical systematics and ecology, 1996, vol. 24, no. 5, p. 415–421. DOI: 10.1016/0305-1978(96)00035-X. [DOI link]
Composition #14: ElShazly, A., Sarg, T., Ateya, A., Aziz, EA., Witte, L., Wink, M. Pyrrolizidine alkaloids of Cynoglossum officinale and Cynoglossum amabile (family Boraginaceae) . biochemical systematics and ecology, 1996, vol. 24, no. 5, p. 415–421. DOI: 10.1016/0305-1978(96)00035-X. [DOI link]
Composition #15: ElShazly, A., Sarg, T., Ateya, A., Aziz, EA., Witte, L., Wink, M. Pyrrolizidine alkaloids of Cynoglossum officinale and Cynoglossum amabile (family Boraginaceae) . biochemical systematics and ecology, 1996, vol. 24, no. 5, p. 415–421. DOI: 10.1016/0305-1978(96)00035-X. [DOI link]
Endpoint study #1: KNIGHT, AP., KIMBERLING, CV., STERMITZ, FR., ROBY, MR. CYNOGLOSSUM-OFFICINALE (HOUNDS-TONGUE) - A CAUSE OF PYRROLIZIDINE ALKALOID POISONING IN HORSES . journal of the american veterinary medical association, 1984, vol. 185, no. 6, p. 647–650. .
Endpoint study #2: KNIGHT, AP., KIMBERLING, CV., STERMITZ, FR., ROBY, MR. CYNOGLOSSUM-OFFICINALE (HOUNDS-TONGUE) - A CAUSE OF PYRROLIZIDINE ALKALOID POISONING IN HORSES . journal of the american veterinary medical association, 1984, vol. 185, no. 6, p. 647–650. .
Endpoint study #3: BAKER, DC., SMART, RA., RALPHS, M., MOLYNEUX, RJ. HOUNDS-TONGUE (CYNOGLOSSUM-OFFICINALE) POISONING IN A CALF. journal of the american veterinary medical association, 1989, vol. 194, no. 7, p. 929–930. .
Endpoint study #4: Stegelmeier, BL., Gardner, DR., James, LF., Molyneux, RJ. Pyrrole detection and the pathologic progression of Cynoglossum officinale (houndstongue) poisoning in horses . journal of veterinary diagnostic investigation, 1996, vol. 8, no. 1, p. 81–90. .