EFSA
ecomole
vscht
  2. Crotalaria spectabilis Roth

Crotalaria spectabilis Roth

Family:
Fabaceae
Approval state:
Approved
Number of articles retrieved:
508
Number of processed references:
12
Compositions
#1: Monocrotaline (seeds) #2: Monocrotaline (leaves) #3: Monocrotaline #4: Tannins (roots, leaves, flower tops) #5: Alkaloids (roots, leaves, flower tops) #6: monocrotaline (seeds) #7: Pyrrolizidine alkaloids (monocrotaline and spectabiline)
Endpoint Studies
#1: Lesion in all major organs leading to mortality in cows . #2: Nephrotoxicity (renal lesions) #3: Lower liver, placental, and fetal weights in maternal rats, lower lung weight of fetuses from treated dams, moderate interstitial pneumonia. #4: Hepatotoxicity - decreased hepatic volume, reduction in lobular size, hepatocellular necrosis, liver fibrosis in pigs #5: Hepatotoxicity leading to mortality in goats that received 2g/kg daily doses of seeds for 35 and 150 days #6: Hepatotoxicity leading to mortality in goat that received a single dose of 20g/kg of seeds. No effects in another goat that received a single dose of seeds at 10g/kg. #7: Anorexia; gross lesions (extensive subcutaneous edema, ascites, and pulmonary edema). Livers were enlarged and hemorrhagic, and friable. #8: Hepatotoxicity, nephrosis and chronic nephritis, gastritis and gastric ulceration in pigs #9: Ascites and severe lesions of liver, kidney and lung in chicken
Genotoxicity
Composition #1: Johnson, A. Earl., Molyneux, Russell J., Merrill, Glory B. Chemistry of toxic range plants. Variation in pyrrolizidine alkaloid content of Senecio, Amsinckia, and Crotalaria species. journal of agricultural and food chemistry, 1985, vol. 33, no. 1, p. 50–5. .
Composition #2: Johnson, A. Earl., Molyneux, Russell J., Merrill, Glory B. Chemistry of toxic range plants. Variation in pyrrolizidine alkaloid content of Senecio, Amsinckia, and Crotalaria species. journal of agricultural and food chemistry, 1985, vol. 33, no. 1, p. 50–5. .
Composition #3: Allen, J.R., Carstens, L.A. Pulmonary vascular occlusions initiated by endothelial lysis in monocrotaline-intoxicated rats. experimental and molecular pathology, 1970, vol. 13, no. 2, p. 159–171. DOI: 10.1016/0014-4800(70)90003-1. [DOI link]
Composition #4: Tinker, R.B., Lauter, W.M. Constituents of Crotalaria spectabilis roth. economic botany, 1956, vol. 10, no. 3, p. 254–257. DOI: 10.1007/BF02899001. [DOI link]
Composition #5: Tinker, R.B., Lauter, W.M. Constituents of Crotalaria spectabilis roth. economic botany, 1956, vol. 10, no. 3, p. 254–257. DOI: 10.1007/BF02899001. [DOI link]
Composition #6: Medeiros, RMT., Gorniak, SL., Guerra, JL. Fetotoxicity and reproductive effects of monocrotaline in pregnant rats. journal of ethnopharmacology, 2000, vol. 69, no. 2, p. 181–188. DOI: 10.1016/S0378-8741(99)00149-X. [DOI link]
Composition #7: Fletcher, Mary T., Mckenzie, Ross A., Blaney, Barry J., Reichmann, Keith G. Pyrrolizidine Alkaloids in Crotalaria Taxa from Northern Australia: Risk to Grazing Livestock . journal of agricultural and food chemistry, 2009, vol. 57, no. 1, p. 311–319. DOI: 10.1021/jf8026099. [DOI link]
Endpoint study #1: Thomas, E. W., Neal, W. M., Ahmann, C. F. The toxicity of Crotalaria spectabilis Roth to livestock and poultry. journal of the american society of agronomy, 1935, vol. 27, p. 499–500. .
Endpoint study #2: Carstens, Laurine A., Allen, James Richard. Arterial degeneration and glomerular hyalinization in the kidney of monocrotaline-intoxicated rats. american journal of pathology, 1970, vol. 60, no. 1, p. 75–92. .
Endpoint study #3: Medeiros, RMT., Gorniak, SL., Guerra, JL. Fetotoxicity and reproductive effects of monocrotaline in pregnant rats. journal of ethnopharmacology, 2000, vol. 69, no. 2, p. 181–188. DOI: 10.1016/S0378-8741(99)00149-X. [DOI link]
Endpoint study #4: Ubiali, Daniel G., Boabaid, Fabiana M., Borges, Nayani A., Caldeira, Flavio H. B., Lodi, Luciano R., Pescador, Caroline A., Souza, Marcos A., Colodel, Edson M. Acute poisoning with Crotalaria spectabilis (Leg. Papilionoideae) seeds in pigs . pesquisa veterinaria brasileira, 2011, vol. 31, no. 4, p. 313–318. .
Endpoint study #5: Pires, Ana Paula C., Oliveira, Mariana C., Braga, Karina M., Malafaia, Pedro., Barros, Janne P. N., Tokarnia, Carlos H., Brito, Marilene F. Study about the sensitivity of goats to the toxicity of crotalarias poisonous for cattle aiming their use for prophylactic measures . pesquisa veterinaria brasileira, 2015, vol. 35, no. 6, p. 501–512. DOI: 10.1590/S0100-736X2015000600003. [DOI link]
Endpoint study #6: Pires, Ana Paula C., Oliveira, Mariana C., Braga, Karina M., Malafaia, Pedro., Barros, Janne P. N., Tokarnia, Carlos H., Brito, Marilene F. Study about the sensitivity of goats to the toxicity of crotalarias poisonous for cattle aiming their use for prophylactic measures . pesquisa veterinaria brasileira, 2015, vol. 35, no. 6, p. 501–512. DOI: 10.1590/S0100-736X2015000600003. [DOI link]
Endpoint study #7: ALLEN, JR., CARSTENS, LA., NORBACK, DH. ULTRASTRUCTURAL AND BIOCHEMICAL CHANGES IN LIVER OF MONOCROTALINE INTOXICATED CHICKENS . toxicology and applied pharmacology, 1970, vol. 16, no. 3, p. 800–&. DOI: 10.1016/0041-008X(70)90086-4. [DOI link]
Endpoint study #8: Souza, AC., Hatayde, MR., Bechara, GH. Pathological aspects of poisoning by Crotalaria spectabilis (Fabaceae) seeds in swine. . pesquisa veterinaria brasileira, 1997, vol. 17, no. 1, p. 12–18. .
Endpoint study #9: Hatayde, MR., Alessi, AC., Berchieri, A., Cafe, MB., Curtarelli, SM. Poisoning of broilers by Crotalaria spectabilis .2. Experimental study on birds during the final phase of growth . arquivo brasileiro de medicina veterinaria e zootecnia, 1997, vol. 49, no. 2, p. 239–249. .