EFSA Compendium of Botanicals

Draft - work in progress

Crateva nurvala Buch.-Ham. // Crateva lophosperma Kurz

Family:: Capparaceae
Approval state:: Approved
Number of articles retrieved:: 80
Number of processed references:: 3

Compositions

#1: quinolone alkaloids in bark #2: crataemine and crataenoside in bark #3: melatonin in stem bark

Endpoint Studies

#1: antifertility activity at 250 mg/kg dose

Genotoxicity

Composition #1: Sinha, Sadhna., Mishra, Priyanka., Amin, Hina., Rah, Bilal., Nayak, Debasis., Goswami, Anindya., Kumar, Naresh., Vishwakarma, Ram., Ghosal, Sabari. A new cytotoxic quinolone alkaloid and a pentacyclic steroidal glycoside from the stem bark of Crataeva nurvala: Study of anti-proliferative and apoptosis inducing property. european journal of medicinal chemistry, 2013, vol. 60, p. 490–496. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH-H2O (9:1)
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

quinolone alkaloids
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

NMR, HMQC, HPTLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

quinolone alkaloids in bark

Composition #2: Sinha, Sadhna., Mishra, Priyanka., Amin, Hina., Rah, Bilal., Nayak, Debasis., Goswami, Anindya., Kumar, Naresh., Vishwakarma, Ram., Ghosal, Sabari. A new cytotoxic quinolone alkaloid and a pentacyclic steroidal glycoside from the stem bark of Crataeva nurvala: Study of anti-proliferative and apoptosis inducing property. european journal of medicinal chemistry, 2013, vol. 60, p. 490–496. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH-H2O (9:1)
Substance:

steroidal glycosides (RF-00011482-PAR)
Additional substance description:

crataemine, crataenoside
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

NMR, HMQC, HPTLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

crataemine and crataenoside in bark

Composition #3: Bhattacharjee, Atanu., Shashidhara, Shastry Chakrakodi., Saha, Santanu. Isolation, purification and structural elucidation of N-acetyl-5-methoxytryptamine (Melatonin) from Crataeva nurvala Buch-Ham stem bark. american journal of phytomedicine and clinical therapeutics, 2014, vol. 2, no. 3), 301-30, p. 9. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

melatonin (RF-00003485-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

column chromatography, TLC, UV, IR, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

melatonin in stem bark

Endpoint study #1: Sharma, B.B., Varshney, M.D., Gupta, D.N., Prakash, A.O. Antifertility screening of plants. Part I. Effect of ten indigenous plants on early pregnancy in albino rats. pharmaceutical biology, 1983, vol. 21, no. 4, p. 183–187. DOI: 10.3109/13880208309070640. [DOI link]

Study relevance:

Human health
Plant part:

Bark (as part-nature) (A066X)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

ethanol 90%
Type of toxicological test:

reproduction toxicity (CHD009TT)
Limit test:

Not applicable
Tested organism:

Rat (as animal) (A0CNV)
Sex:

Male/Female
Exposure duration:

7.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

9
Control groups used:

no data
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight (G225A)
Effect concentration:

250
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

anti-implantation activity
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

antifertility activity at 250 mg/kg dose