EFSA Compendium of Botanicals

Draft - work in progress

Corydalis solida (L.) Clairv. // Corydalis bulbosa (L.) DC.

Family:: Papaveraceae
Approval state:: Approved
Number of articles retrieved:: 142
Number of processed references:: 12

Compositions

#1: Isoquinoline alkaloids in aerial parts #2: Isoquinoline alkaloids #3: Alkaloids (tuber) #4: Corydaline #5: Isoquinoline alkaloids (N-methyllaudanidine) #6: Allocryptopine #7: Tetrahydropalmatin #8: Protopine #9: Palmatine in roots #10: Alkaloids in roots #11: Isocorydine #12: Isoboldine #13: Bulbocapnine #14: Isoquinoline alkaloid (papaverine) #15: Isoquinoline alkaloid (N-methyllaurotetanine) #16: Protopine #17: allocryptopine #18: corydaline #19: aurotensine #20: protopine #21: stylopine #22: tetrahydropalmatine #23: bicuculline #24: dehydronantenine #25: adlumidine #26: Aporphine alkaloids (nantenine) #27: bulbocapnine #28: protopine #29: domesticine #30: oxonantenine #31: corydine #32: predicentrine #33: isoboldine #34: nandazurine #35: thaliporphine #36: glaucine #37: stylopine #38: Isoquinoline alkaloids #39: isoquinoline alkaloids #40: dihydrosanguinarine #41: sinactine #42: Isocorypalmine, dehydrothalictricavine, palmatine in the aerial patrs of the plants #43: Isoquinoline alkaloids in whole plant #44: Dehydrocorydaline, corybulbine, scoulepine in the tubers of the plants #45: corysolidine

Endpoint Studies

Genotoxicity

Composition #1: Ito, Chihiro., Itoigawa, Masataka., Tokuda, Harukuni., Kuchide, Masashi., Nishino, Hoyoku., Furukawa, Hiroshi. Chemopreventive activity of isoquinoline alkaloids from Corydalis plants. planta medica, 2001, vol. 67, no. 5, p. 473–475. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional extraction description:

unspecified
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

Tetrahydropalmatine; Isocorypalmine; Canadine; Stylopine; Corydaline; Corybulbine; Dehydrocorydaline; Yuanamide; Solidaline; Glaucine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

f IR and 1H-NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoquinoline alkaloids in aerial parts

Composition #2: Sener, B., Temizer, H. Chemical Study on Protoberberine Alkaloids from Corydalis solida ssp. brachyloba. . planta medica, 1988, vol. 54, no. 6, p. 584–584. DOI: 10.1055/s-2006-962602. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

Not specified
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

(±)- corydalidzine and 13-methylcolumbamine
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoquinoline alkaloids

Composition #3: Iwasa, J., Naruto, S., Utsui, Y. Studies on the constituent of Corydalis sps. I. Application of thin-layer-and gas-chromatography to Corydalis alkaloids . . yakugaku zasshi : journal of the pharmaceutical society of japan, 1966, vol. 86, no. 5, p. 396–9. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Total alkaloids in tubers = 0.189-888% (different alkaloids = l-tertrahydrocolumbamine 0.0141%; corydalamine 0.0025%; corydaline 0.0487%; l-tetrahydrocopstine 0.0099%; tetrahydropalmatine 0.0033%; protopine 0.0080%)
Analytical method code:

Gaschromatography (GC) (F037A)
Analytical method - additional description:

GC and TLC
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.189-0.888
Internal remarks:

Alkaloids (tuber)

Composition #4: Sturm, Sonja., Seger, Christoph., Stuppner, Hermann. Analysis of Central European Corydalis species by nonaqueous capillary electrophoresis-electrospray ion trap mass spectrometry . journal of chromatography a, 2007, vol. 1159, no. 1-2, p. 42–50. DOI: 10.1016/j.chroma.2007.02.108. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

corydaline (RF-00004504-PAR)
Analytical method code:

Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
Analytical method - additional description:

NACE–ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Corydaline

Composition #5: Sturm, Sonja., Seger, Christoph., Stuppner, Hermann. Analysis of Central European Corydalis species by nonaqueous capillary electrophoresis-electrospray ion trap mass spectrometry . journal of chromatography a, 2007, vol. 1159, no. 1-2, p. 42–50. DOI: 10.1016/j.chroma.2007.02.108. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

N-methyllaudanidine
Analytical method code:

Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
Analytical method - additional description:

NACE–ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoquinoline alkaloids (N-methyllaudanidine)

Composition #6: Sturm, Sonja., Seger, Christoph., Stuppner, Hermann. Analysis of Central European Corydalis species by nonaqueous capillary electrophoresis-electrospray ion trap mass spectrometry . journal of chromatography a, 2007, vol. 1159, no. 1-2, p. 42–50. DOI: 10.1016/j.chroma.2007.02.108. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

allocryptopine (RF-00004136-PAR)
Analytical method code:

Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
Analytical method - additional description:

NACE–ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Allocryptopine

Composition #7: Sturm, Sonja., Seger, Christoph., Stuppner, Hermann. Analysis of Central European Corydalis species by nonaqueous capillary electrophoresis-electrospray ion trap mass spectrometry . journal of chromatography a, 2007, vol. 1159, no. 1-2, p. 42–50. DOI: 10.1016/j.chroma.2007.02.108. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

tetrahydropalmatin (RF-00003602-PAR)
Analytical method code:

Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
Analytical method - additional description:

NACE–ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tetrahydropalmatin

Composition #8: Sturm, Sonja., Seger, Christoph., Stuppner, Hermann. Analysis of Central European Corydalis species by nonaqueous capillary electrophoresis-electrospray ion trap mass spectrometry . journal of chromatography a, 2007, vol. 1159, no. 1-2, p. 42–50. DOI: 10.1016/j.chroma.2007.02.108. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

protopine (RF-00004010-PAR)
Analytical method code:

Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
Analytical method - additional description:

NACE–ESI-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Protopine

Composition #9: Sturm, Sonia., Seger, Christoph., Godejohann, Markus., Spraul, Manfred., Stuppner, Hermann. Conventional sample enrichment strategies combined with high-performance liquid chromatography-solid phase extraction-nuclear magnetic resonance analysis allows analyte identification from a single minuscule Corydalis solida plant tuber . journal of chromatography a, 2007, vol. 1163, no. 1-2, p. 138–144. DOI: 10.1016/j.chroma.2007.06.029. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol 10%
Substance:

palmatine (RF-00003971-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC–DAD–MS–MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Palmatine in roots

Composition #10: Berkov, Strahil., Bastida, Jaume., Nikolova, Milena., Viladomat, Francesc., Codina, Carles. Rapid TLC/GC-MS identification of acetylcholinesterase inhibitors in alkaloid extracts . phytochemical analysis, 2008, vol. 19, no. 5, p. 411–419. DOI: 10.1002/pca.1066. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

solvent extraction with methanol and further purification of the alkaloid fraction
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

The relative proportions of alkaloids in the purified alkaloid fraction reported: Corydine (1%); N-Methyllaurotetanine (29%); Corydaline (14%); Bulbocapnine (29%); Protopine (11%); Corycavine (4%)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

TLC separation and GC analysis
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids in roots

Composition #11: Doncheva, Tsvetelina., Yordanova, Gabriela., Vutov, Vassil., Kostova, Nadezhda., Philipov, Stefan. COMPARATIVE STUDY OF ALKALOID PROFILE OF CORYDALIS SLIVENENSIS VEL. AND CORYDALIS SOLIDA L. . comptes rendus de l academie bulgare des sciences, 2015, vol. 68, no. 7, p. 843–846. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 95%
Substance:

isocorydine (RF-00003443-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

column chromatography, GS-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isocorydine

Composition #12: Doncheva, Tsvetelina., Yordanova, Gabriela., Vutov, Vassil., Kostova, Nadezhda., Philipov, Stefan. COMPARATIVE STUDY OF ALKALOID PROFILE OF CORYDALIS SLIVENENSIS VEL. AND CORYDALIS SOLIDA L. . comptes rendus de l academie bulgare des sciences, 2015, vol. 68, no. 7, p. 843–846. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 95%
Substance:

isoboldine (RF-00003879-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

column chromatography, GS-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoboldine

Composition #13: Doncheva, Tsvetelina., Yordanova, Gabriela., Vutov, Vassil., Kostova, Nadezhda., Philipov, Stefan. COMPARATIVE STUDY OF ALKALOID PROFILE OF CORYDALIS SLIVENENSIS VEL. AND CORYDALIS SOLIDA L. . comptes rendus de l academie bulgare des sciences, 2015, vol. 68, no. 7, p. 843–846. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 95%
Substance:

bulbocapnine (RF-00003719-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

column chromatography, GS-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Bulbocapnine

Composition #14: Doncheva, Tsvetelina., Yordanova, Gabriela., Vutov, Vassil., Kostova, Nadezhda., Philipov, Stefan. COMPARATIVE STUDY OF ALKALOID PROFILE OF CORYDALIS SLIVENENSIS VEL. AND CORYDALIS SOLIDA L. . comptes rendus de l academie bulgare des sciences, 2015, vol. 68, no. 7, p. 843–846. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 95%
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

papaverine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

column chromatography, GS-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoquinoline alkaloid (papaverine)

Composition #15: Doncheva, Tsvetelina., Yordanova, Gabriela., Vutov, Vassil., Kostova, Nadezhda., Philipov, Stefan. COMPARATIVE STUDY OF ALKALOID PROFILE OF CORYDALIS SLIVENENSIS VEL. AND CORYDALIS SOLIDA L. . comptes rendus de l academie bulgare des sciences, 2015, vol. 68, no. 7, p. 843–846. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 95%
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

N-methyllaurotetanine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

column chromatography, GS-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoquinoline alkaloid (N-methyllaurotetanine)

Composition #16: Doncheva, Tsvetelina., Yordanova, Gabriela., Vutov, Vassil., Kostova, Nadezhda., Philipov, Stefan. COMPARATIVE STUDY OF ALKALOID PROFILE OF CORYDALIS SLIVENENSIS VEL. AND CORYDALIS SOLIDA L. . comptes rendus de l academie bulgare des sciences, 2015, vol. 68, no. 7, p. 843–846. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 95%
Substance:

protopine (RF-00004010-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

column chromatography, GS-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Protopine

Composition #17: MANSKE, RHF. THE ALKALOIDS OF FUMARIACEOUS PLANTS .51. CORYDALIS-SOLIDA (L) SWARTZ. canadian journal of chemistry-revue canadienne de chimie, 1956, vol. 34, no. 1, p. 1–3. DOI: 10.1139/v56-001. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Additional extraction description:

unspecified
Substance:

allocryptopine (RF-00004136-PAR)
Analytical method - additional description:

physico-chemical methods - crystalisation
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.005
Internal remarks:

allocryptopine

Composition #18: MANSKE, RHF. THE ALKALOIDS OF FUMARIACEOUS PLANTS .51. CORYDALIS-SOLIDA (L) SWARTZ. canadian journal of chemistry-revue canadienne de chimie, 1956, vol. 34, no. 1, p. 1–3. DOI: 10.1139/v56-001. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

corydaline (RF-00004504-PAR)
Analytical method - additional description:

physico-chemical methods - crystalisation
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.02
Internal remarks:

corydaline

Composition #19: MANSKE, RHF. THE ALKALOIDS OF FUMARIACEOUS PLANTS .51. CORYDALIS-SOLIDA (L) SWARTZ. canadian journal of chemistry-revue canadienne de chimie, 1956, vol. 34, no. 1, p. 1–3. DOI: 10.1139/v56-001. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

scoulerine (RF-00004049-PAR)
Additional substance description:

Aurotensine is a synonym of Scoulerine
Analytical method - additional description:

physico-chemical methods - crystalisation
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

< 0.001
Internal remarks:

aurotensine

Composition #20: MANSKE, RHF. THE ALKALOIDS OF FUMARIACEOUS PLANTS .51. CORYDALIS-SOLIDA (L) SWARTZ. canadian journal of chemistry-revue canadienne de chimie, 1956, vol. 34, no. 1, p. 1–3. DOI: 10.1139/v56-001. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

protopine (RF-00004010-PAR)
Analytical method - additional description:

physico-chemical methods - crystalisation
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.014
Internal remarks:

protopine

Composition #21: MANSKE, RHF. THE ALKALOIDS OF FUMARIACEOUS PLANTS .51. CORYDALIS-SOLIDA (L) SWARTZ. canadian journal of chemistry-revue canadienne de chimie, 1956, vol. 34, no. 1, p. 1–3. DOI: 10.1139/v56-001. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

stylopine (RF-00003592-PAR)
Analytical method - additional description:

physico-chemical methods - crystalisation
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

stylopine

Composition #22: MANSKE, RHF. THE ALKALOIDS OF FUMARIACEOUS PLANTS .51. CORYDALIS-SOLIDA (L) SWARTZ. canadian journal of chemistry-revue canadienne de chimie, 1956, vol. 34, no. 1, p. 1–3. DOI: 10.1139/v56-001. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

tetrahydropalmatin (RF-00003602-PAR)
Analytical method - additional description:

physico-chemical methods - crystalisation
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.01
Internal remarks:

tetrahydropalmatine

Composition #23: KIRYAKOV, HG., ISKRENOVA, E., KUZMANOV, B., EVSTATIEVA, L. ALKALOIDS FROM CORYDALIS-BULBOSA - STRUCTURE OF CORYDIONE. planta medica, 1981, vol. 43, no. 1, p. 51–55. DOI: 10.1055/s-2007-971472. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Bicuculline (RF-00004181-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

bicuculline

Composition #24: KIRYAKOV, HG., ISKRENOVA, E., KUZMANOV, B., EVSTATIEVA, L. ALKALOIDS FROM CORYDALIS-BULBOSA - STRUCTURE OF CORYDIONE. planta medica, 1981, vol. 43, no. 1, p. 51–55. DOI: 10.1055/s-2007-971472. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Dehydronantenine (RF-00004263-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

dehydronantenine

Composition #25: KIRYAKOV, HG., ISKRENOVA, E., KUZMANOV, B., EVSTATIEVA, L. ALKALOIDS FROM CORYDALIS-BULBOSA - STRUCTURE OF CORYDIONE. planta medica, 1981, vol. 43, no. 1, p. 51–55. DOI: 10.1055/s-2007-971472. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

adlumidine (RF-00004130-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

adlumidine

Composition #26: KIRYAKOV, HG., ISKRENOVA, E., KUZMANOV, B., EVSTATIEVA, L. ALKALOIDS FROM CORYDALIS-BULBOSA - STRUCTURE OF CORYDIONE. planta medica, 1981, vol. 43, no. 1, p. 51–55. DOI: 10.1055/s-2007-971472. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Aporphine alkaloids (RF-00010806-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Aporphine alkaloids (nantenine)

Composition #27: KIRYAKOV, HG., ISKRENOVA, E., KUZMANOV, B., EVSTATIEVA, L. ALKALOIDS FROM CORYDALIS-BULBOSA - STRUCTURE OF CORYDIONE. planta medica, 1981, vol. 43, no. 1, p. 51–55. DOI: 10.1055/s-2007-971472. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

bulbocapnine (RF-00003719-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

bulbocapnine

Composition #28: KIRYAKOV, HG., ISKRENOVA, E., KUZMANOV, B., EVSTATIEVA, L. ALKALOIDS FROM CORYDALIS-BULBOSA - STRUCTURE OF CORYDIONE. planta medica, 1981, vol. 43, no. 1, p. 51–55. DOI: 10.1055/s-2007-971472. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

protopine (RF-00004010-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

protopine

Composition #29: KIRYAKOV, HG., ISKRENOVA, E., KUZMANOV, B., EVSTATIEVA, L. ALKALOIDS FROM CORYDALIS-BULBOSA - STRUCTURE OF CORYDIONE. planta medica, 1981, vol. 43, no. 1, p. 51–55. DOI: 10.1055/s-2007-971472. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

domesticine (RF-00004279-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

domesticine

Composition #30: KIRYAKOV, HG., ISKRENOVA, E., KUZMANOV, B., EVSTATIEVA, L. ALKALOIDS FROM CORYDALIS-BULBOSA - STRUCTURE OF CORYDIONE. planta medica, 1981, vol. 43, no. 1, p. 51–55. DOI: 10.1055/s-2007-971472. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

oxonantenine (RF-00003528-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

oxonantenine

Composition #31: KIRYAKOV, HG., ISKRENOVA, E., KUZMANOV, B., EVSTATIEVA, L. ALKALOIDS FROM CORYDALIS-BULBOSA - STRUCTURE OF CORYDIONE. planta medica, 1981, vol. 43, no. 1, p. 51–55. DOI: 10.1055/s-2007-971472. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

corydine (RF-00003752-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

corydine

Composition #32: KIRYAKOV, HG., ISKRENOVA, E., KUZMANOV, B., EVSTATIEVA, L. ALKALOIDS FROM CORYDALIS-BULBOSA - STRUCTURE OF CORYDIONE. planta medica, 1981, vol. 43, no. 1, p. 51–55. DOI: 10.1055/s-2007-971472. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

predicentrine (RF-00004003-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

predicentrine

Composition #33: KIRYAKOV, HG., ISKRENOVA, E., KUZMANOV, B., EVSTATIEVA, L. ALKALOIDS FROM CORYDALIS-BULBOSA - STRUCTURE OF CORYDIONE. planta medica, 1981, vol. 43, no. 1, p. 51–55. DOI: 10.1055/s-2007-971472. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

isoboldine (RF-00003879-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

isoboldine

Composition #34: KIRYAKOV, HG., ISKRENOVA, E., KUZMANOV, B., EVSTATIEVA, L. ALKALOIDS FROM CORYDALIS-BULBOSA - STRUCTURE OF CORYDIONE. planta medica, 1981, vol. 43, no. 1, p. 51–55. DOI: 10.1055/s-2007-971472. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

nandazurine (RF-00003504-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

nandazurine

Composition #35: KIRYAKOV, HG., ISKRENOVA, E., KUZMANOV, B., EVSTATIEVA, L. ALKALOIDS FROM CORYDALIS-BULBOSA - STRUCTURE OF CORYDIONE. planta medica, 1981, vol. 43, no. 1, p. 51–55. DOI: 10.1055/s-2007-971472. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Thaliporphine (RF-00004077-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

thaliporphine

Composition #36: KIRYAKOV, HG., ISKRENOVA, E., KUZMANOV, B., EVSTATIEVA, L. ALKALOIDS FROM CORYDALIS-BULBOSA - STRUCTURE OF CORYDIONE. planta medica, 1981, vol. 43, no. 1, p. 51–55. DOI: 10.1055/s-2007-971472. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

glaucine (RF-00003838-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

glaucine

Composition #37: KIRYAKOV, HG., ISKRENOVA, E., KUZMANOV, B., EVSTATIEVA, L. ALKALOIDS FROM CORYDALIS-BULBOSA - STRUCTURE OF CORYDIONE. planta medica, 1981, vol. 43, no. 1, p. 51–55. DOI: 10.1055/s-2007-971472. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

stylopine (RF-00003592-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

stylopine

Composition #38: KIRYAKOV, HG., ISKRENOVA, E., KUZMANOV, B., EVSTATIEVA, L. ALKALOIDS FROM CORYDALIS-BULBOSA - STRUCTURE OF CORYDIONE. planta medica, 1981, vol. 43, no. 1, p. 51–55. DOI: 10.1055/s-2007-971472. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

The combined alkaloid mixture (0.88 % of dry plant material)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

88
Internal remarks:

Isoquinoline alkaloids

Composition #39: KIRYAKOV, HG., ISKRENOVA, ES. MINOR ALKALOIDS OF CORYDALIS-BULBOSA, STRUCTURE OF BULBODIONE. planta medica, 1984, vol. 50, no. 2, p. 136–138. DOI: 10.1055/s-2007-969652. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

bulbodione (8,11-dioxoaporphine); dehydroglaucine, glaucinone, bicucullinine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

isoquinoline alkaloids

Composition #40: KIRYAKOV, HG., ISKRENOVA, ES. MINOR ALKALOIDS OF CORYDALIS-BULBOSA, STRUCTURE OF BULBODIONE. planta medica, 1984, vol. 50, no. 2, p. 136–138. DOI: 10.1055/s-2007-969652. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

dihydrosanguinarine (RF-00003780-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

dihydrosanguinarine

Composition #41: KIRYAKOV, HG., ISKRENOVA, ES. MINOR ALKALOIDS OF CORYDALIS-BULBOSA, STRUCTURE OF BULBODIONE. planta medica, 1984, vol. 50, no. 2, p. 136–138. DOI: 10.1055/s-2007-969652. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

sinactine (RF-00003578-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

sinactine

Composition #42: SLAVIK, J., DOLEJS, L., SLAVIKOVA, L. ALKALOIDS OF THE PAPAVERACEAE .81. ALKALOIDS FROM CORYDALIS-SOLIDA (L) SW MASS-SPECTROMETRY OF QUATERNARY BENZYLISOQUINOLINE ALKALOIDS . collection of czechoslovak chemical communications, 1985, vol. 50, no. 10, p. 2299–2309. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

isocorypalmine, dehydrothalictricavine, palmatine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

UV, IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isocorypalmine, dehydrothalictricavine, palmatine in the aerial patrs of the plants

Composition #43: SLAVIK, J., DOLEJS, L., SLAVIKOVA, L. ALKALOIDS OF THE PAPAVERACEAE .81. ALKALOIDS FROM CORYDALIS-SOLIDA (L) SW MASS-SPECTROMETRY OF QUATERNARY BENZYLISOQUINOLINE ALKALOIDS . collection of czechoslovak chemical communications, 1985, vol. 50, no. 10, p. 2299–2309. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

Jatrorrhizine, corypalmine, corysamine, cis-N-methylstylopinium hydroxide, coptisine, berberine, columbamine, cin-N-methylcanadinium hydroxide
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

UV, IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoquinoline alkaloids in whole plant

Composition #44: SLAVIK, J., DOLEJS, L., SLAVIKOVA, L. ALKALOIDS OF THE PAPAVERACEAE .81. ALKALOIDS FROM CORYDALIS-SOLIDA (L) SW MASS-SPECTROMETRY OF QUATERNARY BENZYLISOQUINOLINE ALKALOIDS . collection of czechoslovak chemical communications, 1985, vol. 50, no. 10, p. 2299–2309. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

dehydrocorydaline, corybulbine, scoulepine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

UV, IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Dehydrocorydaline, corybulbine, scoulepine in the tubers of the plants

Composition #45: RAHIMIZADEH, M., MILLER, RR., ONUR, MA., GOZLER, T., SHAMMA, M. (+/-)-CORYSOLIDINE, A SPIROBENZYLISOQUINOLINE ALKALOID FROM CORYDALIS-SOLIDA . phytochemistry, 1986, vol. 25, no. 9, p. 2245–2246. DOI: 10.1016/0031-9422(86)80104-2. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

corysolidine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

corysolidine