Draft - work in progress
-
- Corydalis cava (L.) Schweigg. & Körte // Corydalis tuberosa DC.
Corydalis cava (L.) Schweigg. & Körte // Corydalis tuberosa DC.
- Family:
- Papaveraceae
- Approval state:
- Approved
- Number of articles retrieved:
- 203
- Number of processed references:
- 6
Composition #1: Halbsguth, C., Meissner, O., Haberlein, HH. Positive cooperation of protoberberine type 2 alkaloids from Corydalis cava on the GABA(A) binding site . planta medica, 2003, vol. 69, no. 4, p. 305–309. DOI: 10.1055/s-2003-38869.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol 30%
-
Substance:
coptisine (RF-00004215-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Analytical method - additional description:
NMR, HPLC-EI-MS
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
coptisine in rhizomes
Composition #2: Halbsguth, C., Meissner, O., Haberlein, HH. Positive cooperation of protoberberine type 2 alkaloids from Corydalis cava on the GABA(A) binding site . planta medica, 2003, vol. 69, no. 4, p. 305–309. DOI: 10.1055/s-2003-38869.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol 30%
-
Substance:
dehydroapocavidine (RF-00004258-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Analytical method - additional description:
NMR, HPLC-EI-MS
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
dehydroapocavidine in rhizomes
Composition #3: Halbsguth, C., Meissner, O., Haberlein, HH. Positive cooperation of protoberberine type 2 alkaloids from Corydalis cava on the GABA(A) binding site . planta medica, 2003, vol. 69, no. 4, p. 305–309. DOI: 10.1055/s-2003-38869.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol 30%
-
Substance:
dehydrocorydaline (RF-00004259-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Analytical method - additional description:
NMR, HPLC-EI-MS
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
dehydrocorydaline in rhizomes
Composition #4: Halbsguth, C., Meissner, O., Haberlein, HH. Positive cooperation of protoberberine type 2 alkaloids from Corydalis cava on the GABA(A) binding site . planta medica, 2003, vol. 69, no. 4, p. 305–309. DOI: 10.1055/s-2003-38869.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol 30%
-
Substance:
corydaline (RF-00004504-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Analytical method - additional description:
NMR, HPLC-EI-MS
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
corydaline in rhizomes
Composition #5: Halbsguth, C., Meissner, O., Haberlein, HH. Positive cooperation of protoberberine type 2 alkaloids from Corydalis cava on the GABA(A) binding site . planta medica, 2003, vol. 69, no. 4, p. 305–309. DOI: 10.1055/s-2003-38869.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol 30%
-
Substance:
isoapocavidine (RF-00003440-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Analytical method - additional description:
NMR, HPLC-EI-MS
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
isoapocavidine in rhizomes
Composition #6: Halbsguth, C., Meissner, O., Haberlein, HH. Positive cooperation of protoberberine type 2 alkaloids from Corydalis cava on the GABA(A) binding site . planta medica, 2003, vol. 69, no. 4, p. 305–309. DOI: 10.1055/s-2003-38869.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol 30%
-
Substance:
palmatine (RF-00003971-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Analytical method - additional description:
NMR, HPLC-EI-MS
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
palmatine in rhizomes
Composition #7: Halbsguth, C., Meissner, O., Haberlein, HH. Positive cooperation of protoberberine type 2 alkaloids from Corydalis cava on the GABA(A) binding site . planta medica, 2003, vol. 69, no. 4, p. 305–309. DOI: 10.1055/s-2003-38869.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol 30%
-
Substance:
Alkaloids (RF-00004360-PAR)
-
Additional substance description:
isocorypalmine and tetrahydropalmatine (syn for rotundine)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Analytical method - additional description:
NMR, HPLC-EI-MS
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Protoberberine alkaloids: tetrahydropalmatine (syn for rotundine) and isocorypalmine in rhizomes
Composition #8: Halbsguth, C., Meissner, O., Haberlein, HH. Positive cooperation of protoberberine type 2 alkaloids from Corydalis cava on the GABA(A) binding site . planta medica, 2003, vol. 69, no. 4, p. 305–309. DOI: 10.1055/s-2003-38869.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol 30%
-
Substance:
scoulerine (RF-00004049-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Analytical method - additional description:
NMR, HPLC-EI-MS
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
scoulerine in rhizomes
Composition #9: Sturm, Sonja., Seger, Christoph., Stuppner, Hermann. Analysis of Central European Corydalis species by nonaqueous capillary electrophoresis-electrospray ion trap mass spectrometry . journal of chromatography a, 2007, vol. 1159, no. 1-2, p. 42–50. DOI: 10.1016/j.chroma.2007.02.108.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol
-
Substance:
bulbocapnine (RF-00003719-PAR)
-
Analytical method code:
Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
-
Analytical method - additional description:
NACE-ESI-MS
-
Result unit:
Gram/100 gram (G013A)
-
Result expression:
Whole weight (B001A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
5.94
-
Internal remarks:
bulbocapnine in tubers
Composition #10: Sturm, Sonja., Seger, Christoph., Stuppner, Hermann. Analysis of Central European Corydalis species by nonaqueous capillary electrophoresis-electrospray ion trap mass spectrometry . journal of chromatography a, 2007, vol. 1159, no. 1-2, p. 42–50. DOI: 10.1016/j.chroma.2007.02.108.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol
-
Substance:
Canadine (RF-00011169-PAR)
-
Analytical method code:
Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
-
Analytical method - additional description:
NACE-ESI-MS
-
Result unit:
Gram/100 gram (G013A)
-
Result expression:
Whole weight (B001A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
5.41
-
Internal remarks:
canadine in tubers
Composition #11: Sturm, Sonja., Seger, Christoph., Stuppner, Hermann. Analysis of Central European Corydalis species by nonaqueous capillary electrophoresis-electrospray ion trap mass spectrometry . journal of chromatography a, 2007, vol. 1159, no. 1-2, p. 42–50. DOI: 10.1016/j.chroma.2007.02.108.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol
-
Substance:
palmatine (RF-00003971-PAR)
-
Analytical method code:
Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
-
Analytical method - additional description:
NACE-ESI-MS
-
Result unit:
Gram/100 gram (G013A)
-
Result expression:
Whole weight (B001A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.27
-
Internal remarks:
palmatine in tubers
Composition #12: Sturm, Sonja., Seger, Christoph., Stuppner, Hermann. Analysis of Central European Corydalis species by nonaqueous capillary electrophoresis-electrospray ion trap mass spectrometry . journal of chromatography a, 2007, vol. 1159, no. 1-2, p. 42–50. DOI: 10.1016/j.chroma.2007.02.108.
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol
-
Substance:
tetrahydropalmatin (RF-00003602-PAR)
-
Analytical method code:
Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
-
Analytical method - additional description:
NACE-ESI-MS
-
Result unit:
Gram/100 gram (G013A)
-
Result expression:
Whole weight (B001A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
2.04
-
Internal remarks:
tetrahydropalmatin in tubers
Composition #13: Chlebek, Jakub., Macakova, Katerina., Cahlikova, Lucie., Kurfuerst, Milan., Kunes, Jiri., Opletal, Lubomir. Acetylcholinesterase and Butyrylcholinesterase Inhibitory Compounds from Corydalis cava (Fumariaceae) . natural product communications, 2011, vol. 6, no. 5, p. 607–610. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol 95%
-
Substance:
Isoquinoline alkaloids (RF-00004391-PAR)
-
Additional substance description:
corycavamine, corynoline, corycavidine, canadaline, N-methyllaurotetanine
-
Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
-
Analytical method - additional description:
TLC, CC
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
corycavamine, corynoline, corycavidine, canadaline, N-methyllaurotetanine in tubers
Composition #14: Chlebek, Jakub., Macakova, Katerina., Cahlikova, Lucie., Kurfuerst, Milan., Kunes, Jiri., Opletal, Lubomir. Acetylcholinesterase and Butyrylcholinesterase Inhibitory Compounds from Corydalis cava (Fumariaceae) . natural product communications, 2011, vol. 6, no. 5, p. 607–610. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol 95%
-
Substance:
bulbocapnine (RF-00003719-PAR)
-
Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
-
Analytical method - additional description:
TLC, CC
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
bulbocapnine in tubers
Composition #15: Chlebek, Jakub., Macakova, Katerina., Cahlikova, Lucie., Kurfuerst, Milan., Kunes, Jiri., Opletal, Lubomir. Acetylcholinesterase and Butyrylcholinesterase Inhibitory Compounds from Corydalis cava (Fumariaceae) . natural product communications, 2011, vol. 6, no. 5, p. 607–610. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol 95%
-
Substance:
sinoacutine (RF-00004056-PAR)
-
Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
-
Analytical method - additional description:
TLC, CC
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
sinoacutine in tubers
Composition #16: Chlebek, Jakub., Macakova, Katerina., Cahlikova, Lucie., Kurfuerst, Milan., Kunes, Jiri., Opletal, Lubomir. Acetylcholinesterase and Butyrylcholinesterase Inhibitory Compounds from Corydalis cava (Fumariaceae) . natural product communications, 2011, vol. 6, no. 5, p. 607–610. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol 95%
-
Substance:
Canadine (RF-00011169-PAR)
-
Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
-
Analytical method - additional description:
TLC, CC
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
canadine in tubers
Composition #17: Chlebek, Jakub., Macakova, Katerina., Cahlikova, Lucie., Kurfuerst, Milan., Kunes, Jiri., Opletal, Lubomir. Acetylcholinesterase and Butyrylcholinesterase Inhibitory Compounds from Corydalis cava (Fumariaceae) . natural product communications, 2011, vol. 6, no. 5, p. 607–610. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol 95%
-
Substance:
allocryptopine (RF-00004136-PAR)
-
Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
-
Analytical method - additional description:
TLC, CC
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
allocryptopine in tubers
Composition #18: Chlebek, Jakub., Macakova, Katerina., Cahlikova, Lucie., Kurfuerst, Milan., Kunes, Jiri., Opletal, Lubomir. Acetylcholinesterase and Butyrylcholinesterase Inhibitory Compounds from Corydalis cava (Fumariaceae) . natural product communications, 2011, vol. 6, no. 5, p. 607–610. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol 95%
-
Substance:
corydine (RF-00003752-PAR)
-
Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
-
Analytical method - additional description:
TLC, CC
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
corydine in tubers
Composition #19: Salminen, Kaisa A., Meyer, Achim., Jerabkova, Lenka., Korhonen, Laura E., Rahnasto, Minna., Juvonen, Risto O., Imming, Peter., Raunio, Hannu. Inhibition of human drug metabolizing cytochrome P450 enzymes by plant isoquinoline alkaloids . phytomedicine, 2011, vol. 18, no. 6, p. 533–538. DOI: 10.1016/j.phymed.2010.08.012.
[
DOI link]
-
-
Plant part:
Unspecified (A07XD)
-
Additional extraction description:
unspecified
-
Substance:
Isoquinoline alkaloids (RF-00004391-PAR)
-
Additional substance description:
corypalmine, thalictricavine, isocorybulbine, corybulbine
-
Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
-
Analytical method - additional description:
GC/MS
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
corypalmine, thalictricavine, isocorybulbine, corybulbine
Composition #20: Salminen, Kaisa A., Meyer, Achim., Jerabkova, Lenka., Korhonen, Laura E., Rahnasto, Minna., Juvonen, Risto O., Imming, Peter., Raunio, Hannu. Inhibition of human drug metabolizing cytochrome P450 enzymes by plant isoquinoline alkaloids . phytomedicine, 2011, vol. 18, no. 6, p. 533–538. DOI: 10.1016/j.phymed.2010.08.012.
[
DOI link]
-
-
Plant part:
Unspecified (A07XD)
-
Additional extraction description:
unspecified
-
Substance:
stylopine (RF-00003592-PAR)
-
Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
-
Analytical method - additional description:
GC/MS
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
stylopine
Composition #21: Meyer, Achim., Imming, Peter. Benzylisoquinoline Alkaloids from the Papaveraceae: The Heritage of Johannes Gadamer (1867-1928) . journal of natural products, 2011, vol. 74, no. 11, p. 2482–2487. DOI: 10.1021/np2005049.
[
DOI link]
-
-
Plant part:
Unspecified (A07XD)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol
-
Substance:
Isoquinoline alkaloids (RF-00004391-PAR)
-
Additional substance description:
capnoidine
-
Analytical method code:
Chromatographic tests (F015A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
capnoidine
Composition #22: Meyer, Achim., Imming, Peter. Benzylisoquinoline Alkaloids from the Papaveraceae: The Heritage of Johannes Gadamer (1867-1928) . journal of natural products, 2011, vol. 74, no. 11, p. 2482–2487. DOI: 10.1021/np2005049.
[
DOI link]
-
-
Plant part:
Unspecified (A07XD)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol
-
Substance:
Corytuberine (RF-00011231-PAR)
-
Analytical method code:
Chromatographic tests (F015A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
corytuberine
Composition #23: Meyer, Achim., Imming, Peter. Benzylisoquinoline Alkaloids from the Papaveraceae: The Heritage of Johannes Gadamer (1867-1928) . journal of natural products, 2011, vol. 74, no. 11, p. 2482–2487. DOI: 10.1021/np2005049.
[
DOI link]
-
-
Plant part:
Unspecified (A07XD)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol
-
Substance:
glaucine (RF-00003838-PAR)
-
Analytical method code:
Chromatographic tests (F015A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
glaucine
Composition #24: Meyer, Achim., Imming, Peter. Benzylisoquinoline Alkaloids from the Papaveraceae: The Heritage of Johannes Gadamer (1867-1928) . journal of natural products, 2011, vol. 74, no. 11, p. 2482–2487. DOI: 10.1021/np2005049.
[
DOI link]
-
-
Plant part:
Unspecified (A07XD)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol
-
Substance:
Aporphine alkaloids (RF-00010806-PAR)
-
Additional substance description:
Nantenine
-
Analytical method code:
Chromatographic tests (F015A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
aporphine alkaloids (nantenine)
Composition #25: Meyer, Achim., Imming, Peter. Benzylisoquinoline Alkaloids from the Papaveraceae: The Heritage of Johannes Gadamer (1867-1928) . journal of natural products, 2011, vol. 74, no. 11, p. 2482–2487. DOI: 10.1021/np2005049.
[
DOI link]
-
-
Plant part:
Unspecified (A07XD)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol
-
Substance:
protopine (RF-00004010-PAR)
-
Analytical method code:
Chromatographic tests (F015A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
protopine
Composition #26: Novak, Zdenek., Chlebek, Jakub., Opletal, Lubomir., Jiros, Pavel., Macakova, Katerina., Kunes, Jiri., Cahlikova, Lucie. Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its Cholinesterase Activity . natural product communications, 2012, vol. 7, no. 7, p. 859–860. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
unspecified
-
Substance:
Isoquinoline alkaloids (RF-00004391-PAR)
-
Additional substance description:
corylucinine
-
Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
-
Analytical method - additional description:
TLC, HRMS-ESI
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
corylucinine in tubers