EFSA Compendium of Botanicals

Draft - work in progress

Corydalis ambigua Cham.& Schltdl.

Family:: Papaveraceae
Approval state:: Approved
Number of articles retrieved:: 126
Number of processed references:: 6

Compositions

#1: alkaloids #2: Total alkaloids (tubers) #3: Corydaline (tubers) #4: Tetrahydroberberine #5: Protopine (tubers) #6: Benzophenanthridine alkaloids (tubers) #7: Protoberberine (tubers) #8: (+)-Corybulbine (tubers) #9: (+)-Methylcorypalline (tubers) #10: (+)-Corydaline (tubers) #11: Dehydrocorydaline (tubers) #12: alpha-allocryptopine (tubers) #13: Dehydrothalictrifoline (tubers) #14: tetrahydropalmatine (tubers) #15: Tetrahydropalmatine

Endpoint Studies

Genotoxicity

Composition #1: Hsu, B., Kin, K. C. Pharmacological study of tetrahydropalmatine and its analogs. A new type of central nervous system depressant. archives internationales de pharmacodynamie et de therapie, 1962, vol. 139, p. 318–27. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

Not specified
Substance:

tetrahydropalmatin (RF-00003602-PAR)
Additional substance description:

tetrahydropalmatine + 12 other alkaloids
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

alkaloids

Composition #2: Yasuda, Masaho., Konoshima, Masao., Kano, Yoshihiro. Pharmacognostical and botanical studies on the crude drugs in Hokkaido (IV). Determination of tertiary alkaloids in Corydalis ambigua by high performance liquid chromatography. shoyakugaku zasshi, 1986, vol. 40, no. 1, p. 61–4. .

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Additional extraction description:

Not specified
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Total alkaloids
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.45
Internal remarks:

Total alkaloids (tubers)

Composition #3: Yasuda, Masaho., Konoshima, Masao., Kano, Yoshihiro. Pharmacognostical and botanical studies on the crude drugs in Hokkaido (IV). Determination of tertiary alkaloids in Corydalis ambigua by high performance liquid chromatography. shoyakugaku zasshi, 1986, vol. 40, no. 1, p. 61–4. .

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Additional extraction description:

Not specified
Substance:

corydaline (RF-00004504-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.21
Internal remarks:

Corydaline (tubers)

Composition #4: Schroeder, K. M., Yu, K. W., Zhao, L. K., Eaton, J. B., Segerberg, M., Lukas, R. J., Wu, J. TETRAHYDROBERBERINE, A NOVEL NICOTINIC ACETYLCHOLINE RECEPTOR MODULATOR.. society for neuroscience abstract viewer and itinerary planner, 2002, vol. 2002, p. Abstract No. 137.7–Abstract No. 137.7. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

Not specified
Substance:

Canadine (RF-00011169-PAR)
Additional substance description:

tetrahydroberberine
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tetrahydroberberine

Composition #5: Yang, Zhiyou., Liu, Zhihui., Jiang, Baohong., Teng, Fukang., Wang, Yu., Han, Na., Guo, Dean., Yin, Jun. Ambidalmines A-E and ambidimerine F: Bioactive dihydrobenzophenanthridine alkaloids from Corydalis ambigua var. amurensis . european journal of medicinal chemistry, 2014, vol. 84, p. 417–424. DOI: 10.1016/j.ejmech.2014.07.043. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Additional extraction description:

unspecified
Substance:

protopine (RF-00004010-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Protopine (tubers)

Composition #6: Yang, Zhiyou., Liu, Zhihui., Jiang, Baohong., Teng, Fukang., Wang, Yu., Han, Na., Guo, Dean., Yin, Jun. Ambidalmines A-E and ambidimerine F: Bioactive dihydrobenzophenanthridine alkaloids from Corydalis ambigua var. amurensis . european journal of medicinal chemistry, 2014, vol. 84, p. 417–424. DOI: 10.1016/j.ejmech.2014.07.043. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Boiling ethanol-water 80 :20
Substance:

benzophenanthridine alkaloids (RF-00010802-PAR)
Additional substance description:

ambidalmine A, B, C, D, E, ambidimerine F
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Benzophenanthridine alkaloids (tubers)

Composition #7: Yang, Zhiyou., Liu, Zhihui., Jiang, Baohong., Teng, Fukang., Wang, Yu., Han, Na., Guo, Dean., Yin, Jun. Ambidalmines A-E and ambidimerine F: Bioactive dihydrobenzophenanthridine alkaloids from Corydalis ambigua var. amurensis . european journal of medicinal chemistry, 2014, vol. 84, p. 417–424. DOI: 10.1016/j.ejmech.2014.07.043. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Additional extraction description:

unspecified
Substance:

protoberberine (RF-00003553-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Protoberberine (tubers)

Composition #8: NARUTO, S., KANEKO, H. CONSTITUENTS OF CORYDALIS SPECIES .11. ALKALOIDS FROM CORYDALIS-AMBIGUA. phytochemistry, 1973, vol. 12, no. 12, p. 3008–3009. DOI: 10.1016/0031-9422(73)80533-3. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

(+)-corybulbine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

Preparative column chromatography or TLC
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0035
Internal remarks:

(+)-Corybulbine (tubers)

Composition #9: NARUTO, S., KANEKO, H. CONSTITUENTS OF CORYDALIS SPECIES .11. ALKALOIDS FROM CORYDALIS-AMBIGUA. phytochemistry, 1973, vol. 12, no. 12, p. 3008–3009. DOI: 10.1016/0031-9422(73)80533-3. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

(+)-methylcorypalline
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

Preparative column chromatography or TLC
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.001
Internal remarks:

(+)-Methylcorypalline (tubers)

Composition #10: NARUTO, S., KANEKO, H. CONSTITUENTS OF CORYDALIS SPECIES .11. ALKALOIDS FROM CORYDALIS-AMBIGUA. phytochemistry, 1973, vol. 12, no. 12, p. 3008–3009. DOI: 10.1016/0031-9422(73)80533-3. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

corydaline (RF-00004504-PAR)
Additional substance description:

(+)-corydaline
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

Preparative column chromatography or TLC
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.019
Internal remarks:

(+)-Corydaline (tubers)

Composition #11: NARUTO, S., KANEKO, H. CONSTITUENTS OF CORYDALIS SPECIES .11. ALKALOIDS FROM CORYDALIS-AMBIGUA. phytochemistry, 1973, vol. 12, no. 12, p. 3008–3009. DOI: 10.1016/0031-9422(73)80533-3. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

benzophenanthridine alkaloids (RF-00010802-PAR)
Additional substance description:

dehydrocorydaline
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

Preparative column chromatography or TLC
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.003
Internal remarks:

Dehydrocorydaline (tubers)

Composition #12: NARUTO, S., KANEKO, H. CONSTITUENTS OF CORYDALIS SPECIES .11. ALKALOIDS FROM CORYDALIS-AMBIGUA. phytochemistry, 1973, vol. 12, no. 12, p. 3008–3009. DOI: 10.1016/0031-9422(73)80533-3. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

allocryptopine (RF-00004136-PAR)
Additional substance description:

alpha-allocryptopine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

Preparative column chromatography or TLC
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.001
Internal remarks:

alpha-allocryptopine (tubers)

Composition #13: NARUTO, S., KANEKO, H. CONSTITUENTS OF CORYDALIS SPECIES .11. ALKALOIDS FROM CORYDALIS-AMBIGUA. phytochemistry, 1973, vol. 12, no. 12, p. 3008–3009. DOI: 10.1016/0031-9422(73)80533-3. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

benzophenanthridine alkaloids (RF-00010802-PAR)
Additional substance description:

dehydrothalictrifoline
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

Preparative column chromatography or TLC
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.007
Internal remarks:

Dehydrothalictrifoline (tubers)

Composition #14: NARUTO, S., KANEKO, H. CONSTITUENTS OF CORYDALIS SPECIES .11. ALKALOIDS FROM CORYDALIS-AMBIGUA. phytochemistry, 1973, vol. 12, no. 12, p. 3008–3009. DOI: 10.1016/0031-9422(73)80533-3. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

tetrahydropalmatin (RF-00003602-PAR)
Additional substance description:

rac-tetrahydropalmatine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

Preparative column chromatography or TLC
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.003
Internal remarks:

tetrahydropalmatine (tubers)

Composition #15: ZHU, XZ. DEVELOPMENT OF NATURAL-PRODUCTS AS DRUGS ACTING ON CENTRAL-NERVOUS-SYSTEM . memorias do instituto oswaldo cruz, 1991, vol. 86, p. 173–175. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

tetrahydropalmatin (RF-00003602-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tetrahydropalmatine