EFSA Compendium of Botanicals

Draft - work in progress

Coronilla scorpioides (L.) Koch.

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 54
Number of processed references:: 4

Compositions

#1: furocoumarins (psoralen, daphnoretin, scopoletin, umbelliferone) (seed) #2: cardenolides (corotoxigenin, frugoside, frugocorotoxigenin, coronillobioside), seeds #3: cardenolides (glucocorotoxigenin, scorpioside, coronillobioside, glucocoroglaucigenin) (seeds) #4: psoralen (root) quantitative #5: coumarins (Umbelliferone, scopoletin, daphnoretin, marmesin - whole plant) #6: psoralen (leaves) quantitative #7: psoralen (stem) quantitative #8: psoralen (seed) quantitative

Endpoint Studies

Genotoxicity

Composition #1: Beletskii, Yu. N., Komissarenko, N. F. Coumarins of the seeds of Coronilla scorpioides. khimiya prirodnykh soedinenii, 1967, vol. 3, no. 4, p. 277–8. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Furanocoumarins (RF-00004381-PAR)
Additional substance description:

psoralen, daphnoretin, scopoletin, umbelliferone
Analytical method code:

Traditional analytical techniques (wet chemical tests) (F003A)
Analytical method - additional description:

melting point, tlc, ..
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

furocoumarins (psoralen, daphnoretin, scopoletin, umbelliferone) (seed)

Composition #2: Komissarenko, N. F., Beletskii, Yu. N. Cardenolides of the seeds of Coronilla scorpioides. khimiya prirodnykh soedinenii, 1968, vol. 4, no. 1, p. 56. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol, chlororom-ethanol
Substance:

cardenolides (RF-00004389-PAR)
Additional substance description:

corotoxigenin, frugoside, frugocorotoxigenin, coronillobioside
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

IR, melting point
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cardenolides (corotoxigenin, frugoside, frugocorotoxigenin, coronillobioside), seeds

Composition #3: Kovalev, V. N., Komissarenko, A. N. Cardenolides of Coronilla glauca and C. scorpioides. khimiya prirodnykh soedinenii, 1985, vol. (5), p. 676–9. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol, chloroform-ethanol
Substance:

cardenolides (RF-00004389-PAR)
Additional substance description:

glucocorotoxigenin, scorpioside, coronillobioside, glucocoroglaucigenin
Analytical method code:

Traditional analytical techniques (wet chemical tests) (F003A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cardenolides (glucocorotoxigenin, scorpioside, coronillobioside, glucocoroglaucigenin) (seeds)

Composition #4: Innocenti, G., Piovan, A., Caniato, R., Filippini, R., Cappelletti, EM. Within-plant distribution of coumarins in Coronilla and Securigera species . international journal of pharmacognosy, 1996, vol. 34, no. 2, p. 114–118. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

psoralen (RF-00004015-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

HPLC, MS, UV
Result unit:

ppm (G288A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2973
Internal remarks:

psoralen (root) quantitative

Composition #5: Innocenti, G., Piovan, A., Caniato, R., Filippini, R., Cappelletti, EM. Within-plant distribution of coumarins in Coronilla and Securigera species . international journal of pharmacognosy, 1996, vol. 34, no. 2, p. 114–118. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

Umbelliferone, scopoletin, daphnoretin, marmesin
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

UV,MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

coumarins (Umbelliferone, scopoletin, daphnoretin, marmesin - whole plant)

Composition #6: Innocenti, G., Piovan, A., Caniato, R., Filippini, R., Cappelletti, EM. Within-plant distribution of coumarins in Coronilla and Securigera species . international journal of pharmacognosy, 1996, vol. 34, no. 2, p. 114–118. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

psoralen (RF-00004015-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

HPLC, MS, UV
Result unit:

ppm (G288A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1221
Internal remarks:

psoralen (leaves) quantitative

Composition #7: Innocenti, G., Piovan, A., Caniato, R., Filippini, R., Cappelletti, EM. Within-plant distribution of coumarins in Coronilla and Securigera species . international journal of pharmacognosy, 1996, vol. 34, no. 2, p. 114–118. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

psoralen (RF-00004015-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

HPLC, MS, UV
Result unit:

ppm (G288A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1722
Internal remarks:

psoralen (stem) quantitative

Composition #8: Innocenti, G., Piovan, A., Caniato, R., Filippini, R., Cappelletti, EM. Within-plant distribution of coumarins in Coronilla and Securigera species . international journal of pharmacognosy, 1996, vol. 34, no. 2, p. 114–118. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

psoralen (RF-00004015-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

HPLC, MS, UV
Result unit:

ppm (G288A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

11345
Internal remarks:

psoralen (seed) quantitative