Draft - work in progress
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- Cilantro (as plant) // Coriandrum odoratum Lour. // Coriandrum sativum L.
Cilantro (as plant) // Coriandrum odoratum Lour. // Coriandrum sativum L.
- Family:
- Apiaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 3902
- Number of processed references:
- 6
Composition #1: Nassar, M. I., Abdel-Fattah, M. E., Gaara, A. H., El-Khrisy, E. A. M. Constituents of Coriandrum sativum and Pituranthos triradiatus. bulletin of the faculty of pharmacy (cairo university), 1993, vol. 31, no. 3, p. 399–401. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Substance:
imperatorin (RF-00003874-PAR)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
imperatorin in leaves
Composition #2: Nassar, M. I., Abdel-Fattah, M. E., Gaara, A. H., El-Khrisy, E. A. M. Constituents of Coriandrum sativum and Pituranthos triradiatus. bulletin of the faculty of pharmacy (cairo university), 1993, vol. 31, no. 3, p. 399–401. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Substance:
umbelliferone (RF-00004096-PAR)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
umbelliferone in leaves
Composition #3: Nassar, M. I., Abdel-Fattah, M. E., Gaara, A. H., El-Khrisy, E. A. M. Constituents of Coriandrum sativum and Pituranthos triradiatus. bulletin of the faculty of pharmacy (cairo university), 1993, vol. 31, no. 3, p. 399–401. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Substance:
scopoletin (RF-00004048-PAR)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
scopoletin in leaves
Composition #4: Nassar, M. I., Abdel-Fattah, M. E., Gaara, A. H., El-Khrisy, E. A. M. Constituents of Coriandrum sativum and Pituranthos triradiatus. bulletin of the faculty of pharmacy (cairo university), 1993, vol. 31, no. 3, p. 399–401. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Substance:
Bergapten (RF-00003837-PAR)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
bergapten in leaves
Composition #5: Lopez, Maria D., Jordan, Maria J., Pascual-Villalobos, Maria J. Toxic compounds in essential oils of coriander, caraway and basil active against stored rice pests . journal of stored products research, 2008, vol. 44, no. 3, p. 273–278. DOI: 10.1016/j.jspr.2008.02.005.
[
DOI link]
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
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Additional extraction description:
TLC fractionation
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Substance:
Carvone (RF-0538-001-PPP)
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Analytical method code:
Gaschromatography (GC) (F037A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
90
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Internal remarks:
Carvone in essential oil of seeds
Composition #6: Lopez, Maria D., Jordan, Maria J., Pascual-Villalobos, Maria J. Toxic compounds in essential oils of coriander, caraway and basil active against stored rice pests . journal of stored products research, 2008, vol. 44, no. 3, p. 273–278. DOI: 10.1016/j.jspr.2008.02.005.
[
DOI link]
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
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Additional extraction description:
TLC fractionation
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Substance:
Camphor (RF-00003986-PAR)
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Analytical method code:
Gaschromatography (GC) (F037A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
287
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Internal remarks:
Camphor in essential oil of seeds
Composition #7: Ramirez Reyes, Mariana., Reyes-Esparza, Jorge., Torres Angeles, Oscar., Rodriguez-Fragoso, Lourdes. Mutagenicity and Safety Evaluation of Water Extract of Coriander sativum Leaves . journal of food science, 2010, vol. 75, no. 1, p. T6–T12. DOI: 10.1111/j.1750-3841.2009.01403.x.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
distilled water, then 80% methanol, then the essential oils
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Substance:
Camphor (RF-00003986-PAR)
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Analytical method code:
GC-FID-MS (F607A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Camphor in essential oil of leaves
Endpoint study
#1: Damasceno, D.C., Volpato, G.T., Lemonica, I.P. A review of antifertility folkloric plants tested in laboratory animals. revista brasileira de plantas medicinais, 2002, vol. 5, no. 1, p. 19–26. .
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Study relevance:
Human health
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Plant part:
Seed (as part-nature) (A066P)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
aqueous
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Type of toxicological test:
reproduction toxicity (CHD009TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Control groups used:
no data
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligram/kilogram (G061A)
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Effect concentration:
250-500
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Critical effect:
REPRODUCTIVE (TOX05A)
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Target tissue:
urogenital: Ovaries (TT047A)
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Effect description:
Reproductive effects in the ovaries of rats (no details - REVIEW).
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Effect or parameter linked to the endpoint:
reproduction (CHD014BE)
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Internal remarks:
Reproductive effects in rats (review)
Endpoint study
#2: Patel, Dipak., Desai, Swati., Devkar, Ranjitsinh., Ramachandran, A. V. ACUTE AND SUB-CHRONIC TOXICOLOGICAL EVALUATION OF HYDRO-METHANOLIC EXTRACT OF CORIANDRUM SATIVUM L. SEEDS . excli journal, 2012, vol. 11, p. 566–575. .
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Study relevance:
Human health
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Plant part:
Seed (as part-nature) (A066P)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
Methanol (80:20 v/v)
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Type of toxicological test:
short-term toxicity (CHD017TT)
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Tested organism:
House mouse (as animal) (A0CNT)
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Strain of test organism:
Swiss (CHD005ST)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
6
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Control groups used:
yes, concurrent vehicle
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligrams per kilogram body weight per day (G211A)
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Effect concentration:
2000-3000
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Critical effect:
SYSTEMIC (TOX01A)
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Target tissue:
Digestive (TT002A)
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Effect description:
Reduced body weight gain (3000 mg/kg-day only) and food intake, and increased water intake.
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Effect or parameter linked to the endpoint:
body weight (CHD005BE)
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Internal remarks:
Reduced body weight gain and food intake in mice
Genotox #1: Mahmoud, I., Alkofahi, A., Abdelaziz, A. Mutagenic and toxic activities of several spices and some jordanian medicinal plants. pharmaceutical biology, 1992, vol. 30, no. 2, p. 81–85. DOI: 10.3109/13880209209053961.
[
DOI link]
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Study category:
Mutagenicity
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Type of toxicological test:
bacterial reverse mutation assay (CHD028TT)
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Tested organism:
Salmonella typhimurium (as organism) (A0CPZ)
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Strain of test organism:
TA 102 (CHD025ST)
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Endpoint measured:
gene mutation
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Remarks on genotox study:
Fruit extract was mutagenic to TA 102 and TA 98 strains in the Ames test.
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Internal remarks:
Mutagenicity of fruit
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Internal ID:
eid=2-s2.0-84907105429
Genotox #2: Ramirez Reyes, Mariana., Reyes-Esparza, Jorge., Torres Angeles, Oscar., Rodriguez-Fragoso, Lourdes. Mutagenicity and Safety Evaluation of Water Extract of Coriander sativum Leaves . journal of food science, 2010, vol. 75, no. 1, p. T6–T12. DOI: 10.1111/j.1750-3841.2009.01403.x.
[
DOI link]
-
Study category:
Mutagenicity
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Type of toxicological test:
bacterial reverse mutation assay (CHD028TT)
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Tested organism:
Salmonella typhimurium (as organism) (A0CPZ)
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Strain of test organism:
TA 97 (CHD028ST)
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Exogenous metabolic activation applied:
without
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Endpoint measured:
gene mutation
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Remarks on genotox study:
Mutagenicity in Ames test at concentrations of 1.6-8 ug/ml for TA97 and T102 strains.
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Internal remarks:
Mutagenicity of extract of leaves
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Internal ID:
WOS:000273839400075