EFSA
ecomole
vscht
  2. Coptis japonica (Thunb.) Makino

Coptis japonica (Thunb.) Makino

Family:
Ranunculaceae
Approval state:
Approved
Number of articles retrieved:
665
Number of processed references:
6
Compositions
#1: berberine chloride (roots) #2: Palmatine iodide (roots) #3: Coptisine chloride (roots) #4: Berberine #5: 8-oxo-epiberberine (rhizomes) #6: alkaloid derivative: 6-([1,3]Dioxolo[4,5-g]isoquinoline-5-carbonyl)-2,3-dimethoxybenzoic acid methyl ester (rhizomes) #7: 8-oxocoptisine (rhizomes) #8: oxyberberine (rhizomes) #9: Jatrorrhizine (dried plant parts) #10: Demethyleneberberine (dried plant parts) #11: berberine derivatives: 13-Hydroxyberberine and 8-Oxoberberine (dried plant parts) #12: palmatine derivative: Tetrahydropalmatine (dried plant parts) #13: Magnoflorine (dried plant parts) #14: Isoquinoline alkaloids (dried plant parts) #15: coptisine (rhizome) #16: berberine (rhizome) #17: palmatine (rhizome) #18: columbamine (rhizome) #19: Berberine (rhizome) #20: coptisine (rhizome) #21: jatrorrhizine (rhizome) #22: magnoflorine (rhizome) #23: palmatine (rhizome)
Endpoint Studies
Genotoxicity
Composition #1: Chae, SH., Jeong, IH., Choi, DH., Oh, JW., Ahn, YJ. Growth-inhibiting effects of Coptis japonica root-derived isoquinoline alkaloids on human intestinal bacteria . journal of agricultural and food chemistry, 1999, vol. 47, no. 3, p. 934–938. DOI: 10.1021/jf980991o. [DOI link]
Composition #2: Chae, SH., Jeong, IH., Choi, DH., Oh, JW., Ahn, YJ. Growth-inhibiting effects of Coptis japonica root-derived isoquinoline alkaloids on human intestinal bacteria . journal of agricultural and food chemistry, 1999, vol. 47, no. 3, p. 934–938. DOI: 10.1021/jf980991o. [DOI link]
Composition #3: Chae, SH., Jeong, IH., Choi, DH., Oh, JW., Ahn, YJ. Growth-inhibiting effects of Coptis japonica root-derived isoquinoline alkaloids on human intestinal bacteria . journal of agricultural and food chemistry, 1999, vol. 47, no. 3, p. 934–938. DOI: 10.1021/jf980991o. [DOI link]
Composition #4: Chintalwar, GJ., Gupta, S., Roja, G., Bapat, VA. Protoberberine alkaloids from callus and cell suspension cultures of Tinospora cordifolia . pharmaceutical biology, 2003, vol. 41, no. 2, p. 81–86. DOI: 10.1076/phbi.41.2.81.14243. [DOI link]
Composition #5: Min, Yong Deuk., Yang, Min Cheol., Lee, Kyu Ha., Kim, Kyung Ran., Choi, Sang Un., Lee, Kang Ro. Protoberberine alkaloids and their reversal activity of P-gp expressed multidrug resistance (MDR) from the rhizome of Coptis japonica Makino . archives of pharmacal research, 2006, vol. 29, no. 9, p. 757–761. DOI: 10.1007/BF02974076. [DOI link]
Composition #6: Min, Yong Deuk., Yang, Min Cheol., Lee, Kyu Ha., Kim, Kyung Ran., Choi, Sang Un., Lee, Kang Ro. Protoberberine alkaloids and their reversal activity of P-gp expressed multidrug resistance (MDR) from the rhizome of Coptis japonica Makino . archives of pharmacal research, 2006, vol. 29, no. 9, p. 757–761. DOI: 10.1007/BF02974076. [DOI link]
Composition #7: Min, Yong Deuk., Yang, Min Cheol., Lee, Kyu Ha., Kim, Kyung Ran., Choi, Sang Un., Lee, Kang Ro. Protoberberine alkaloids and their reversal activity of P-gp expressed multidrug resistance (MDR) from the rhizome of Coptis japonica Makino . archives of pharmacal research, 2006, vol. 29, no. 9, p. 757–761. DOI: 10.1007/BF02974076. [DOI link]
Composition #8: Min, Yong Deuk., Yang, Min Cheol., Lee, Kyu Ha., Kim, Kyung Ran., Choi, Sang Un., Lee, Kang Ro. Protoberberine alkaloids and their reversal activity of P-gp expressed multidrug resistance (MDR) from the rhizome of Coptis japonica Makino . archives of pharmacal research, 2006, vol. 29, no. 9, p. 757–761. DOI: 10.1007/BF02974076. [DOI link]
Composition #9: Deevanhxay, Phengxay., Suzuki, Makoto., Maeshibu, Nariaki., Li, He., Tanaka, Ken., Hirose, Sachio. Simultaneous characterization of quaternary alkaloids, 8-oxoprotoberberine alkaloids, and a steroid compound in Coscinium fenestratum by liquid chromatography hybrid ion trap time-of-flight mass spectrometry . journal of pharmaceutical and biomedical analysis, 2009, vol. 50, no. 3, p. 413–425. DOI: 10.1016/j.jpba.2009.05.023. [DOI link]
Composition #10: Deevanhxay, Phengxay., Suzuki, Makoto., Maeshibu, Nariaki., Li, He., Tanaka, Ken., Hirose, Sachio. Simultaneous characterization of quaternary alkaloids, 8-oxoprotoberberine alkaloids, and a steroid compound in Coscinium fenestratum by liquid chromatography hybrid ion trap time-of-flight mass spectrometry . journal of pharmaceutical and biomedical analysis, 2009, vol. 50, no. 3, p. 413–425. DOI: 10.1016/j.jpba.2009.05.023. [DOI link]
Composition #11: Deevanhxay, Phengxay., Suzuki, Makoto., Maeshibu, Nariaki., Li, He., Tanaka, Ken., Hirose, Sachio. Simultaneous characterization of quaternary alkaloids, 8-oxoprotoberberine alkaloids, and a steroid compound in Coscinium fenestratum by liquid chromatography hybrid ion trap time-of-flight mass spectrometry . journal of pharmaceutical and biomedical analysis, 2009, vol. 50, no. 3, p. 413–425. DOI: 10.1016/j.jpba.2009.05.023. [DOI link]
Composition #12: Deevanhxay, Phengxay., Suzuki, Makoto., Maeshibu, Nariaki., Li, He., Tanaka, Ken., Hirose, Sachio. Simultaneous characterization of quaternary alkaloids, 8-oxoprotoberberine alkaloids, and a steroid compound in Coscinium fenestratum by liquid chromatography hybrid ion trap time-of-flight mass spectrometry . journal of pharmaceutical and biomedical analysis, 2009, vol. 50, no. 3, p. 413–425. DOI: 10.1016/j.jpba.2009.05.023. [DOI link]
Composition #13: Deevanhxay, Phengxay., Suzuki, Makoto., Maeshibu, Nariaki., Li, He., Tanaka, Ken., Hirose, Sachio. Simultaneous characterization of quaternary alkaloids, 8-oxoprotoberberine alkaloids, and a steroid compound in Coscinium fenestratum by liquid chromatography hybrid ion trap time-of-flight mass spectrometry . journal of pharmaceutical and biomedical analysis, 2009, vol. 50, no. 3, p. 413–425. DOI: 10.1016/j.jpba.2009.05.023. [DOI link]
Composition #14: Deevanhxay, Phengxay., Suzuki, Makoto., Maeshibu, Nariaki., Li, He., Tanaka, Ken., Hirose, Sachio. Simultaneous characterization of quaternary alkaloids, 8-oxoprotoberberine alkaloids, and a steroid compound in Coscinium fenestratum by liquid chromatography hybrid ion trap time-of-flight mass spectrometry . journal of pharmaceutical and biomedical analysis, 2009, vol. 50, no. 3, p. 413–425. DOI: 10.1016/j.jpba.2009.05.023. [DOI link]
Composition #15: Hasada, Keiko., Yoshida, Takamitsu., Yamazaki, Takeshi., Sugimoto, Naoki., Nishimura, Tetsuji., Nagatsu, Akito., Mizukami, Hajime. Application of H-1-NMR spectroscopy to validation of berberine alkaloid reagents and to chemical evaluation of Coptidis Rhizoma . journal of natural medicines, 2011, vol. 65, no. 2, p. 262–267. DOI: 10.1007/s11418-010-0490-x. [DOI link]
Composition #16: Hasada, Keiko., Yoshida, Takamitsu., Yamazaki, Takeshi., Sugimoto, Naoki., Nishimura, Tetsuji., Nagatsu, Akito., Mizukami, Hajime. Application of H-1-NMR spectroscopy to validation of berberine alkaloid reagents and to chemical evaluation of Coptidis Rhizoma . journal of natural medicines, 2011, vol. 65, no. 2, p. 262–267. DOI: 10.1007/s11418-010-0490-x. [DOI link]
Composition #17: Hasada, Keiko., Yoshida, Takamitsu., Yamazaki, Takeshi., Sugimoto, Naoki., Nishimura, Tetsuji., Nagatsu, Akito., Mizukami, Hajime. Application of H-1-NMR spectroscopy to validation of berberine alkaloid reagents and to chemical evaluation of Coptidis Rhizoma . journal of natural medicines, 2011, vol. 65, no. 2, p. 262–267. DOI: 10.1007/s11418-010-0490-x. [DOI link]
Composition #18: LIU, YM., SHEU, SJ., CHIOU, SH., CHANG, HC., CHEN, YP. CAPILLARY ELECTROPHORETIC ANALYSES OF ALKALOIDS IN COMMERCIAL SAMPLES OF COPTIDIS RHIZOMA . phytochemical analysis, 1994, vol. 5, no. 5, p. 256–260. DOI: 10.1002/pca.2800050508. [DOI link]
Composition #19: LIU, YM., SHEU, SJ., CHIOU, SH., CHANG, HC., CHEN, YP. CAPILLARY ELECTROPHORETIC ANALYSES OF ALKALOIDS IN COMMERCIAL SAMPLES OF COPTIDIS RHIZOMA . phytochemical analysis, 1994, vol. 5, no. 5, p. 256–260. DOI: 10.1002/pca.2800050508. [DOI link]
Composition #20: LIU, YM., SHEU, SJ., CHIOU, SH., CHANG, HC., CHEN, YP. CAPILLARY ELECTROPHORETIC ANALYSES OF ALKALOIDS IN COMMERCIAL SAMPLES OF COPTIDIS RHIZOMA . phytochemical analysis, 1994, vol. 5, no. 5, p. 256–260. DOI: 10.1002/pca.2800050508. [DOI link]
Composition #21: LIU, YM., SHEU, SJ., CHIOU, SH., CHANG, HC., CHEN, YP. CAPILLARY ELECTROPHORETIC ANALYSES OF ALKALOIDS IN COMMERCIAL SAMPLES OF COPTIDIS RHIZOMA . phytochemical analysis, 1994, vol. 5, no. 5, p. 256–260. DOI: 10.1002/pca.2800050508. [DOI link]
Composition #22: LIU, YM., SHEU, SJ., CHIOU, SH., CHANG, HC., CHEN, YP. CAPILLARY ELECTROPHORETIC ANALYSES OF ALKALOIDS IN COMMERCIAL SAMPLES OF COPTIDIS RHIZOMA . phytochemical analysis, 1994, vol. 5, no. 5, p. 256–260. DOI: 10.1002/pca.2800050508. [DOI link]
Composition #23: LIU, YM., SHEU, SJ., CHIOU, SH., CHANG, HC., CHEN, YP. CAPILLARY ELECTROPHORETIC ANALYSES OF ALKALOIDS IN COMMERCIAL SAMPLES OF COPTIDIS RHIZOMA . phytochemical analysis, 1994, vol. 5, no. 5, p. 256–260. DOI: 10.1002/pca.2800050508. [DOI link]