EFSA Compendium of Botanicals

Draft - work in progress

Coptis deltoidea C.Y.Cheng & P.K.Hsiao

Family:: Ranunculaceae
Approval state:: Approved
Number of articles retrieved:: 81
Number of processed references:: 7

Compositions

#1: berberin, bark, nmr #2: coptisine, bark, nmr #3: palmatine, bark, nmr #4: epiberberine, HPLC-DAD #5: coptisine, HPLC-DAD #6: palmatine, HPLC-DAD #7: jatrorrhizine, HPLC-DAD #8: berberine, HPLC-DAD #9: tetrahydropalmatine, palmatine, magnoflorine, columbamine, berberine, woremine, berberrubine, coptisine #10: selinene, root, GC-MS #11: selinene, root, GC-MS #12: columbamine , roots, HPLC-DAD #13: epiberberine, roots, HPLC-DAD #14: coptisine, roots, HPLC-DAD #15: jatrorrhizine, roots, HPLC-DAD #16: berberine, roots, HPLC-DAD #17: magnoflorine, roots, NMR #18: palmatine, roots, HPLC-DAD #19: protoberberine alkaloids, roots, NMR #20: coptisine,roots, HPLC #21: berberine,roots, HPLC #22: epiberberine, roots, HPLC #23: columbamine,roots, HPLC #24: palmatine,roots, HPLC #25: jatrorrhizine,roots, HPLC

Endpoint Studies

Genotoxicity

Composition #1: Li, Chia-Ying., Tsai, Sung-I., Damu, Amooru G., Wu, Tian-Shung. A rapid and simple determination of protoberberine alkaloids in Rhizoma Coptidis by 1H NMR and its application for quality control of commercial prescriptions. journal of pharmaceutical and biomedical analysis, 2009, vol. 49, no. 5, p. 1272–1276. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

berberine (RF-00003706-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.7
Internal remarks:

berberin, bark, nmr

Composition #2: Li, Chia-Ying., Tsai, Sung-I., Damu, Amooru G., Wu, Tian-Shung. A rapid and simple determination of protoberberine alkaloids in Rhizoma Coptidis by 1H NMR and its application for quality control of commercial prescriptions. journal of pharmaceutical and biomedical analysis, 2009, vol. 49, no. 5, p. 1272–1276. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

coptisine (RF-00004215-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.5
Internal remarks:

coptisine, bark, nmr

Composition #3: Li, Chia-Ying., Tsai, Sung-I., Damu, Amooru G., Wu, Tian-Shung. A rapid and simple determination of protoberberine alkaloids in Rhizoma Coptidis by 1H NMR and its application for quality control of commercial prescriptions. journal of pharmaceutical and biomedical analysis, 2009, vol. 49, no. 5, p. 1272–1276. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

palmatine (RF-00003971-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.3
Internal remarks:

palmatine, bark, nmr

Composition #4: Dou, Sheng-shan., Zhu, Shuang-lai., Dai, Wei-xing., Zhang, Wei-dong., Zhang, Yi., Liu, Run-hui. Qualitative and quantitative analysis for the quality control of Rhizoma Coptidis by HPLC-DAD and HPLC-ESI-MS. chemical research in chinese universities, 2010, vol. 26, no. 5, p. 735–741. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hydrochloric acid methanol
Substance:

Epiberberine (RF-00011173-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

228.53-311.1
Internal remarks:

epiberberine, HPLC-DAD

Composition #5: Dou, Sheng-shan., Zhu, Shuang-lai., Dai, Wei-xing., Zhang, Wei-dong., Zhang, Yi., Liu, Run-hui. Qualitative and quantitative analysis for the quality control of Rhizoma Coptidis by HPLC-DAD and HPLC-ESI-MS. chemical research in chinese universities, 2010, vol. 26, no. 5, p. 735–741. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hydrochloric acid methanol
Substance:

coptisine (RF-00004215-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

20.4-33.48
Internal remarks:

coptisine, HPLC-DAD

Composition #6: Dou, Sheng-shan., Zhu, Shuang-lai., Dai, Wei-xing., Zhang, Wei-dong., Zhang, Yi., Liu, Run-hui. Qualitative and quantitative analysis for the quality control of Rhizoma Coptidis by HPLC-DAD and HPLC-ESI-MS. chemical research in chinese universities, 2010, vol. 26, no. 5, p. 735–741. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hydrochloric acid methanol
Substance:

palmatine (RF-00003971-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

34.43-57.76
Internal remarks:

palmatine, HPLC-DAD

Composition #7: Dou, Sheng-shan., Zhu, Shuang-lai., Dai, Wei-xing., Zhang, Wei-dong., Zhang, Yi., Liu, Run-hui. Qualitative and quantitative analysis for the quality control of Rhizoma Coptidis by HPLC-DAD and HPLC-ESI-MS. chemical research in chinese universities, 2010, vol. 26, no. 5, p. 735–741. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hydrochloric acid methanol
Substance:

jatrorrhizine (RF-00003887-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

9.57-13.59
Internal remarks:

jatrorrhizine, HPLC-DAD

Composition #8: Dou, Sheng-shan., Zhu, Shuang-lai., Dai, Wei-xing., Zhang, Wei-dong., Zhang, Yi., Liu, Run-hui. Qualitative and quantitative analysis for the quality control of Rhizoma Coptidis by HPLC-DAD and HPLC-ESI-MS. chemical research in chinese universities, 2010, vol. 26, no. 5, p. 735–741. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hydrochloric acid methanol
Substance:

berberine (RF-00003706-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

57.38-90.37
Internal remarks:

berberine, HPLC-DAD

Composition #9: Liu, Lu., Wang, Zhi-Bin., Song, Yang., Yang, Jing., Wu, Li-Jun., Yang, Bing-You., Wang, Qiu-Hong., Wang, Li-Qian., Wang, Ru-Xuan., Yang, Chun-Juan. Simultaneous Determination of Eight Alkaloids in Rat Plasma by UHPLC-MS/MS after Oral Administration of Coptis deltoidea C. Y. Cheng et Hsiao and Coptis chinensis Franch. . molecules (basel, switzerland), 2016, vol. 21, no. 7 . DOI: 10.3390/molecules21070913. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

protoberberine (RF-00003553-PAR)
Additional substance description:

tetrahydropalmatine, palmatine, magnoflorine, columbamine, berberine, woremine, berberrubine, coptisine
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tetrahydropalmatine, palmatine, magnoflorine, columbamine, berberine, woremine, berberrubine, coptisine

Composition #10: Gao, Xin., Yang, Xiuwei., Mitrevski, Blagoj S., Marriott, Philip J. Headspace solid-phase microextraction combined with GC x GC-TOFMS for the analysis of volatile compounds of Coptis species rhizomes . journal of separation science, 2011, vol. 34, no. 10, p. 1157–1166. DOI: 10.1002/jssc.201100022. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Substance:

beta-selinene (RF-00011306-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

GC-MS-TOF
Result unit:

Percent (G138A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4
Internal remarks:

selinene, root, GC-MS

Composition #11: Gao, Xin., Yang, Xiuwei., Mitrevski, Blagoj S., Marriott, Philip J. Headspace solid-phase microextraction combined with GC x GC-TOFMS for the analysis of volatile compounds of Coptis species rhizomes . journal of separation science, 2011, vol. 34, no. 10, p. 1157–1166. DOI: 10.1002/jssc.201100022. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Substance:

alpha-Selinene (RF-00010780-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

GC-MS-TOF
Result unit:

Percent (G138A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.8
Internal remarks:

selinene, root, GC-MS

Composition #12: Fan, Gang., Tao, Ling-hui., Yue, Qing-hong., Kuang, Ting-ting., Tang, Ce., Yang, Yong-dong., Luo, Wei-zao., Zhou, Xiang-dong., Zhang, Yi. Metabolic Discrimination of Rhizoma Coptidis from Different Species Using H-1 NMR Spectroscopy and Principal Component Analysis . planta medica, 2012, vol. 78, no. 6, p. 641–648. DOI: 10.1055/s-0031-1298240. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol-d4 (CD3OD)
Substance:

columbamine (RF-00011147-PAR)
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

NMR
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2
Internal remarks:

columbamine , roots, HPLC-DAD

Composition #13: Fan, Gang., Tao, Ling-hui., Yue, Qing-hong., Kuang, Ting-ting., Tang, Ce., Yang, Yong-dong., Luo, Wei-zao., Zhou, Xiang-dong., Zhang, Yi. Metabolic Discrimination of Rhizoma Coptidis from Different Species Using H-1 NMR Spectroscopy and Principal Component Analysis . planta medica, 2012, vol. 78, no. 6, p. 641–648. DOI: 10.1055/s-0031-1298240. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol-d4 (CD3OD)
Substance:

Epiberberine (RF-00011173-PAR)
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

NMR
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

8
Internal remarks:

epiberberine, roots, HPLC-DAD

Composition #14: Fan, Gang., Tao, Ling-hui., Yue, Qing-hong., Kuang, Ting-ting., Tang, Ce., Yang, Yong-dong., Luo, Wei-zao., Zhou, Xiang-dong., Zhang, Yi. Metabolic Discrimination of Rhizoma Coptidis from Different Species Using H-1 NMR Spectroscopy and Principal Component Analysis . planta medica, 2012, vol. 78, no. 6, p. 641–648. DOI: 10.1055/s-0031-1298240. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol-d4 (CD3OD)
Substance:

coptisine (RF-00004215-PAR)
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

NMR
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

12.5
Internal remarks:

coptisine, roots, HPLC-DAD

Composition #15: Fan, Gang., Tao, Ling-hui., Yue, Qing-hong., Kuang, Ting-ting., Tang, Ce., Yang, Yong-dong., Luo, Wei-zao., Zhou, Xiang-dong., Zhang, Yi. Metabolic Discrimination of Rhizoma Coptidis from Different Species Using H-1 NMR Spectroscopy and Principal Component Analysis . planta medica, 2012, vol. 78, no. 6, p. 641–648. DOI: 10.1055/s-0031-1298240. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol-d4 (CD3OD)
Substance:

jatrorrhizine (RF-00003887-PAR)
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

NMR
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

8
Internal remarks:

jatrorrhizine, roots, HPLC-DAD

Composition #16: Fan, Gang., Tao, Ling-hui., Yue, Qing-hong., Kuang, Ting-ting., Tang, Ce., Yang, Yong-dong., Luo, Wei-zao., Zhou, Xiang-dong., Zhang, Yi. Metabolic Discrimination of Rhizoma Coptidis from Different Species Using H-1 NMR Spectroscopy and Principal Component Analysis . planta medica, 2012, vol. 78, no. 6, p. 641–648. DOI: 10.1055/s-0031-1298240. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol-d4 (CD3OD)
Substance:

berberine (RF-00003706-PAR)
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

NMR
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

40
Internal remarks:

berberine, roots, HPLC-DAD

Composition #17: Fan, Gang., Tao, Ling-hui., Yue, Qing-hong., Kuang, Ting-ting., Tang, Ce., Yang, Yong-dong., Luo, Wei-zao., Zhou, Xiang-dong., Zhang, Yi. Metabolic Discrimination of Rhizoma Coptidis from Different Species Using H-1 NMR Spectroscopy and Principal Component Analysis . planta medica, 2012, vol. 78, no. 6, p. 641–648. DOI: 10.1055/s-0031-1298240. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol-d4 (CD3OD)
Substance:

magnoflorine (RF-00003919-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

magnoflorine, roots, NMR

Composition #18: Fan, Gang., Tao, Ling-hui., Yue, Qing-hong., Kuang, Ting-ting., Tang, Ce., Yang, Yong-dong., Luo, Wei-zao., Zhou, Xiang-dong., Zhang, Yi. Metabolic Discrimination of Rhizoma Coptidis from Different Species Using H-1 NMR Spectroscopy and Principal Component Analysis . planta medica, 2012, vol. 78, no. 6, p. 641–648. DOI: 10.1055/s-0031-1298240. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol-d4 (CD3OD)
Substance:

palmatine (RF-00003971-PAR)
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

NMR
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5
Internal remarks:

palmatine, roots, HPLC-DAD

Composition #19: Fan, Gang., Zhang, Meng Ying., Zhou, Xiang Dong., Lai, Xian Rong., Yue, Qing Hong., Tang, Ce., Luo, Wei Zao., Zhang, Yi. Quality evaluation and species differentiation of Rhizoma coptidis by using proton nuclear magnetic resonance spectroscopy . analytica chimica acta, 2012, vol. 747, p. 76–83. DOI: 10.1016/j.aca.2012.08.038. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hyrdochloric acid methanol
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

protoberberine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

protoberberine alkaloids, roots, NMR

Composition #20: Lv, Xiumei., Li, Yan., Tang, Ce., Zhang, Yi., Zhang, Jing., Fan, Gang. Integration of HPLC-based fingerprint and quantitative analyses for differentiating botanical species and geographical growing origins of Rhizoma coptidis . pharmaceutical biology, 2016, vol. 54, no. 12, p. 3264–3271. DOI: 10.1080/13880209.2016.1223699. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

coptisine (RF-00004215-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

25.95
Internal remarks:

coptisine,roots, HPLC

Composition #21: Lv, Xiumei., Li, Yan., Tang, Ce., Zhang, Yi., Zhang, Jing., Fan, Gang. Integration of HPLC-based fingerprint and quantitative analyses for differentiating botanical species and geographical growing origins of Rhizoma coptidis . pharmaceutical biology, 2016, vol. 54, no. 12, p. 3264–3271. DOI: 10.1080/13880209.2016.1223699. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

berberine (RF-00003706-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

76.11
Internal remarks:

berberine,roots, HPLC

Composition #22: Lv, Xiumei., Li, Yan., Tang, Ce., Zhang, Yi., Zhang, Jing., Fan, Gang. Integration of HPLC-based fingerprint and quantitative analyses for differentiating botanical species and geographical growing origins of Rhizoma coptidis . pharmaceutical biology, 2016, vol. 54, no. 12, p. 3264–3271. DOI: 10.1080/13880209.2016.1223699. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Epiberberine (RF-00011173-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

13.91
Internal remarks:

epiberberine, roots, HPLC

Composition #23: Lv, Xiumei., Li, Yan., Tang, Ce., Zhang, Yi., Zhang, Jing., Fan, Gang. Integration of HPLC-based fingerprint and quantitative analyses for differentiating botanical species and geographical growing origins of Rhizoma coptidis . pharmaceutical biology, 2016, vol. 54, no. 12, p. 3264–3271. DOI: 10.1080/13880209.2016.1223699. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

columbamine (RF-00011147-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.25
Internal remarks:

columbamine,roots, HPLC

Composition #24: Lv, Xiumei., Li, Yan., Tang, Ce., Zhang, Yi., Zhang, Jing., Fan, Gang. Integration of HPLC-based fingerprint and quantitative analyses for differentiating botanical species and geographical growing origins of Rhizoma coptidis . pharmaceutical biology, 2016, vol. 54, no. 12, p. 3264–3271. DOI: 10.1080/13880209.2016.1223699. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

jatrorrhizine (RF-00003887-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.47
Internal remarks:

palmatine,roots, HPLC

Composition #25: Lv, Xiumei., Li, Yan., Tang, Ce., Zhang, Yi., Zhang, Jing., Fan, Gang. Integration of HPLC-based fingerprint and quantitative analyses for differentiating botanical species and geographical growing origins of Rhizoma coptidis . pharmaceutical biology, 2016, vol. 54, no. 12, p. 3264–3271. DOI: 10.1080/13880209.2016.1223699. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

jatrorrhizine (RF-00003887-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Result unit:

Milligram/gram (G060A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.47
Internal remarks:

jatrorrhizine,roots, HPLC