EFSA Compendium of Botanicals

Draft - work in progress

Commiphora mukul (Hook. ex Stocks) Engl.

Family:: Burseraceae
Approval state:: Approved
Number of articles retrieved:: 543
Number of processed references:: 4

Compositions

#1: Eugenol in essential oil from gum-resin #2: Myrcene in essential oil from gum-resin #3: tannins in whole plant #4: alkaloids in whole plant

Endpoint Studies

#1: Adverse events in humans: Pathological changes in liver and lungs, vertigo, mouth dryness, weight loss, impotence, dry skin. #2: rhabdomyolysis with hemoglobinuria in human

Genotoxicity

Composition #1: Saxena, V. K., Sharma, R. N. Constituents of the essential oil from Commiphora mukul gum resin. journal of medicinal and aromatic plant sciences, 1998, vol. 20, no. 1, p. 55–56. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

essential oil from gum-resin
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Eugenol in essential oil from gum-resin

Composition #2: Saxena, V. K., Sharma, R. N. Constituents of the essential oil from Commiphora mukul gum resin. journal of medicinal and aromatic plant sciences, 1998, vol. 20, no. 1, p. 55–56. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

essential oil from gum-resin
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Myrcene in essential oil from gum-resin

Composition #3: Pendyala, V., Janga, R.B., Suryadevara, V. Phytochemical and pharmacological evaluation of Commiphora mukul for antidepressant activity in albino mice. asian journal of pharmaceutical and clinical research, 2017, vol. 10, no. 1, p. 360–363. DOI: 10.22159/ajpcr.2017.v10i1.15481. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hydroalcoholic extract + ethyl acetate + petroleum ether (plant grounded)
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tannins in whole plant

Composition #4: Pendyala, V., Janga, R.B., Suryadevara, V. Phytochemical and pharmacological evaluation of Commiphora mukul for antidepressant activity in albino mice. asian journal of pharmaceutical and clinical research, 2017, vol. 10, no. 1, p. 360–363. DOI: 10.22159/ajpcr.2017.v10i1.15481. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hydroalcoholic extract + ethyl acetate + petroleum ether (plant grounded)
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

alkaloids in whole plant

Endpoint study #1: Bhatti, H.B.A., Gogtay, N.J., Kochar, N.R., Daivi, S.S., Kshirsagar, N.A. Adverse drug reactions to Indian traditional remedies: Past, present and future. adverse drug reaction bulletin, 2004, no. 225, p. 1–4. .

Study relevance:

Human health
Type of toxicological test:

not reported (CHD015TT)
Limit test:

Not applicable
Tested organism:

Human (as organism) (A056J)
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NOT REPORTED (TOX17A)
Effect description:

Adverse events in humans: Pathological changes in liver and lungs, vertigo, mouth dryness, weight loss, impotence, dry skin.
Effect or parameter linked to the endpoint:

other (CHD003BE)
Internal remarks:

Adverse events in humans: Pathological changes in liver and lungs, vertigo, mouth dryness, weight loss, impotence, dry skin.

Endpoint study #2: Bianchi, A., Cantu, P., Firenzuoli, F., Mazzanti, G., Menniti-Ippolito, F., Raschetti, R. Rhabdomyolysis caused by Commiphora mukul, a natural lipid-lowering agent . annals of pharmacotherapy, 2004, vol. 38, no. 7-8, p. 1222–1225. DOI: 10.1345/aph.1D486. [DOI link]

Study relevance:

Human health
Plant part:

Unspecified (A07XD)
Additional plant/substance description:

resine extract
Type of toxicological test:

subchronic (CHD013TT)
Limit test:

Not applicable
Tested organism:

Human (as organism) (A056J)
Sex:

Male
Exposure duration:

2.0
Unit of exposure duration:

Week (G205A)
Number of organisms dosed:

1
Control groups used:

no
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per day (G209A)
Effect concentration:

900
Critical effect:

HEMOPOIETIC (TOX10A)
Effect description:

rhabdomyolysis with hemoglobinuria after 2 weeks of treatment
Effect or parameter linked to the endpoint:

haematology (CHD023BE)
Internal remarks:

rhabdomyolysis with hemoglobinuria in human