EFSA Compendium of Botanicals

Draft - work in progress

Colchicum luteum Baker

Family:: Colchicaceae
Approval state:: Approved
Number of articles retrieved:: 75
Number of processed references:: 7

Compositions

#1: Colchicum luteum corm contains 0.26-0.27% of colchicine. #2: several colchicine-related alkaloids were detected in different part of the plant e.g. bulbs, leaves, stalks, pod, seeds at different steps of plant development #3: colchicine, colchiceine, N-formyldeacetylcolchicine, 3-demethylcolchicine, 8-1uminocolchicine, luteidine, luteine, kesselringine in aerial parts #4: Colchicine, N-formyldeacetylcolchicine, 3-demethylcolchicine, 8-1umicolchicine in corms #5: Colchicine, 3-demethylcolchicine, colchiceine in unspecified parts #6: cornigerine, gama-lumicolchicine in seeds #7: Luteidine Oxime, quinoxaline, Leuteinone Dioxime, collutine N-oxide #8: luteinine, luteicine, luteidine, collutine in aerial parts #9: luteicine in unspecified part #10: luteidine in unspecified part #11: N-formyl de-acetyl colchicine, 3-demethyl colchicine and b-lumicolchicine in corms #12: cornigerine and c-lumicolchicine in seeds #13: lutidine #14: colchicine in corms #15: colchicine in seeds #16: colchicine, N-formyl de-acetyl colchicine, 3-demethyl colchicine and b-lumicolchicine, lutidine, lutein, collutine N-oxide and kesselringine in aerial parts

Endpoint Studies

#1: crude methanolic extract of various plant parts shows enzyme inhibition activity (strongest for (89%) lipoxygenase and also for actylcholinesterase and butyrylcholinesterase enzymes) #2: gastrointestinal side effects and potential mortality

Genotoxicity

Composition #1: Wahid, M. A., Samiullah. Standardization of active principles of indigenous pharmacopoeial drugs found in West Pakistan. pakistan journal of scientific and industrial research, 1960, vol. 3, p. 228–30. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Colchicin (RF-00000506-VET)
Result unit:

Gram/100 gram (G013A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.26-0.27
Internal remarks:

Colchicum luteum corm contains 0.26-0.27% of colchicine.

Composition #2: Sadykov, A. S., Yusupov, M. K., Chommadov, B. Composition of alkaloids in Colchicum luteum at different growth stages. rastitel'nye resursy, 1969, vol. 5, no. 3, p. 441–4. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

several colchicine dervived alkaloids (2-, and 3-demethylcolchicine ; cholchiceine; luminocolchicine)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

several colchicine-related alkaloids were detected in different part of the plant e.g. bulbs, leaves, stalks, pod, seeds at different steps of plant development

Composition #3: Chommadov, B., Yusupov, M.K. Alkaloids of Colchicum luteum. chemistry of natural compounds, 1985, vol. 21, no. 6, p. 770–773. DOI: 10.1007/BF00576217. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional extraction description:

unspecified
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

colchicine, colchiceine, N-formyldeacetylcolchicine, 3-demethylcolchicine, 8-1uminocolchicine, luteidine, luteine, kesselringine
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

colchicine, colchiceine, N-formyldeacetylcolchicine, 3-demethylcolchicine, 8-1uminocolchicine, luteidine, luteine, kesselringine in aerial parts

Composition #4: Chommadov, B., Yusupov, M.K. Alkaloids of Colchicum luteum. chemistry of natural compounds, 1985, vol. 21, no. 6, p. 770–773. DOI: 10.1007/BF00576217. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Additional extraction description:

unspecified
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

Colchicine, N-formyldeacetylcolchicine, 3-demethylcolchicine, 8-1umicolchicine
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Colchicine, N-formyldeacetylcolchicine, 3-demethylcolchicine, 8-1umicolchicine in corms

Composition #5: Chommadov, B., Yusupov, M.K. Alkaloids of Colchicum luteum. chemistry of natural compounds, 1985, vol. 21, no. 6, p. 770–773. DOI: 10.1007/BF00576217. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

Colchicine, 3-demethylcolchicine, colchiceine
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Colchicine, 3-demethylcolchicine, colchiceine in unspecified parts

Composition #6: Chommadov, B., Yusupov, M.K. Alkaloids of Colchicum luteum. chemistry of natural compounds, 1985, vol. 21, no. 6, p. 770–773. DOI: 10.1007/BF00576217. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Additional extraction description:

unspecified
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

cornigerine, gama-lumicolchicine
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cornigerine, gama-lumicolchicine in seeds

Composition #7: Chommadov, B., Yusupov, M.K. Alkaloids of Colchicum luteum. chemistry of natural compounds, 1985, vol. 21, no. 6, p. 770–773. DOI: 10.1007/BF00576217. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dry pyridine and ethanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

Luteidine Oxime, quinoxaline, Leuteinone Dioxime, collutine N-oxide
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Luteidine Oxime, quinoxaline, Leuteinone Dioxime, collutine N-oxide

Composition #8: Mukhamed'yarova, N.L., Yusupov, M.K., Aslanov, Kh.A., Sadykov, A.S. Structure and absolute configuration of collutine. chemistry of natural compounds, 1976, vol. 11, no. 6, p. 781–783. DOI: 10.1007/BF00568470. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform-methanol-benzene / n-butanol- 5% acetic acid
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

luteinine, luteicine, luteidine, collutine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

luteinine, luteicine, luteidine, collutine in aerial parts

Composition #9: Kametani, T., Koizumi, M. Phenethylisoquinoline Alkaloids. alkaloids: chemistry and pharmacology, 1990, vol. 36, no. C, p. 171–223. DOI: 10.1016/S0099-9598(08)60083-8. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

luteicine
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

luteicine in unspecified part

Composition #10: Kametani, T., Koizumi, M. Phenethylisoquinoline Alkaloids. alkaloids: chemistry and pharmacology, 1990, vol. 36, no. C, p. 171–223. DOI: 10.1016/S0099-9598(08)60083-8. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

luteidine
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

luteidine in unspecified part

Composition #11: Sapra, Sameer., Bhalla, Yashika., Nandani., Sharma, Sahil., Singh, Gagandip., Nepali, Kunal., Budhiraja, Abhishek., Dhar, Kanaya L. Colchicine and its various physicochemical and biological aspects. medicinal chemistry research, 2013, vol. 22, no. 2, p. 531–547. DOI: 10.1007/s00044-012-0077-z. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Additional extraction description:

(corms)
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

N-formyl de-acetyl colchicine, 3-demethyl colchicine and b-lumicolchicine
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

N-formyl de-acetyl colchicine, 3-demethyl colchicine and b-lumicolchicine in corms

Composition #12: Sapra, Sameer., Bhalla, Yashika., Nandani., Sharma, Sahil., Singh, Gagandip., Nepali, Kunal., Budhiraja, Abhishek., Dhar, Kanaya L. Colchicine and its various physicochemical and biological aspects. medicinal chemistry research, 2013, vol. 22, no. 2, p. 531–547. DOI: 10.1007/s00044-012-0077-z. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

cornigerine and c-lumicolchicine
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cornigerine and c-lumicolchicine in seeds

Composition #13: Sapra, Sameer., Bhalla, Yashika., Nandani., Sharma, Sahil., Singh, Gagandip., Nepali, Kunal., Budhiraja, Abhishek., Dhar, Kanaya L. Colchicine and its various physicochemical and biological aspects. medicinal chemistry research, 2013, vol. 22, no. 2, p. 531–547. DOI: 10.1007/s00044-012-0077-z. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

lutidine
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lutidine

Composition #14: Sapra, Sameer., Bhalla, Yashika., Nandani., Sharma, Sahil., Singh, Gagandip., Nepali, Kunal., Budhiraja, Abhishek., Dhar, Kanaya L. Colchicine and its various physicochemical and biological aspects. medicinal chemistry research, 2013, vol. 22, no. 2, p. 531–547. DOI: 10.1007/s00044-012-0077-z. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Additional extraction description:

(corms)
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

colchicine
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.25
Internal remarks:

colchicine in corms

Composition #15: Sapra, Sameer., Bhalla, Yashika., Nandani., Sharma, Sahil., Singh, Gagandip., Nepali, Kunal., Budhiraja, Abhishek., Dhar, Kanaya L. Colchicine and its various physicochemical and biological aspects. medicinal chemistry research, 2013, vol. 22, no. 2, p. 531–547. DOI: 10.1007/s00044-012-0077-z. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

colchicine
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.4
Internal remarks:

colchicine in seeds

Composition #16: Sapra, Sameer., Bhalla, Yashika., Nandani., Sharma, Sahil., Singh, Gagandip., Nepali, Kunal., Budhiraja, Abhishek., Dhar, Kanaya L. Colchicine and its various physicochemical and biological aspects. medicinal chemistry research, 2013, vol. 22, no. 2, p. 531–547. DOI: 10.1007/s00044-012-0077-z. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

colchicine, N-formyl de-acetyl colchicine, 3-demethyl colchicine and b-lumicolchicine, lutidine, lutein, collutine N-oxide and kesselringine
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

colchicine, N-formyl de-acetyl colchicine, 3-demethyl colchicine and b-lumicolchicine, lutidine, lutein, collutine N-oxide and kesselringine in aerial parts

Endpoint study #1: Ahmad, Bashir., Khan, Haroon., Bashir, Shumaila., Nisar, M., Hassan, M. Inhibition activities of colchicum luteum baker on lipoxygenase and other enzymes . journal of enzyme inhibition and medicinal chemistry, 2006, vol. 21, no. 4, p. 449–452. DOI: 10.1080/14756360600586148. [DOI link]

Study relevance:

Human health
Plant part:

Unspecified (A07XD)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

methanolic extracts (chloroform, ethyl acetate, n-butanol and aqueous)
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Enzyme inhibition (CHD067EP)
Concentration unit:

Percent (G138A)
Effect concentration:

89
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

crude methanolic extract shows enzyme inhibition (strongest for (89%) lipoxygenase and also for actylcholinesterase and butyrylcholinesterase enzymes)
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

crude methanolic extract of various plant parts shows enzyme inhibition activity (strongest for (89%) lipoxygenase and also for actylcholinesterase and butyrylcholinesterase enzymes)

Endpoint study #2: Sapra, Sameer., Bhalla, Yashika., Nandani., Sharma, Sahil., Singh, Gagandip., Nepali, Kunal., Budhiraja, Abhishek., Dhar, Kanaya L. Colchicine and its various physicochemical and biological aspects. medicinal chemistry research, 2013, vol. 22, no. 2, p. 531–547. DOI: 10.1007/s00044-012-0077-z. [DOI link]

Study relevance:

Human health
Plant part:

Bulb / clove (as part-nature) (A067A)
Additional plant/substance description:

(all plant especially bulb)
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

Human (as organism) (A056J)
Sex:

No data
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Control groups used:

no data
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

causing vomiting, violent purging, serious inflammation of the stomach and bowels and death
Effect or parameter linked to the endpoint:

no data (CHD002BE)
Internal remarks:

gastrointestinal side effects and potential mortality