EFSA Compendium of Botanicals

Draft - work in progress

Cistus ladanifer L. // Cistus ladanosma Hoffmanns. // Cistus viscosus Stokes

Family:: Cistaceae
Approval state:: Approved
Number of articles retrieved:: 564
Number of processed references:: 8

Compositions

#1: isopinocamphone in leaves and twigs #2: toluene in leaves and twigs #3: naphthalene in leaves and twigs #4: coumaric acid in leaves GS-MS #5: oxalic acid in leaves GC-MS #6: 4-Hydroxybenzoic acid in leaves GC-MS #7: 4-hydroxybenzoic acid, leaves, HPLC #8: p-coumaric acid, leaves, HPLC #9: gallic acid, leaves, HPLC #10: tyrosol, leaves, HPLC #11: 2,2,6-Trimethylcyclohexanone, leaves, GC-FID #12: tannins, aerial part of plant, we chemical test #13: 1,8-cineol, leaves, gc-ms #14: diterpenes, leaves throughfall, HPLC #15: protoanthocyanidins, aerial part of plants

Endpoint Studies

Genotoxicity

Composition #1: Li, Guang., Zheng, Yaoqing., Sun, Yiliang., Liu, Mixin., Wu, Zhuping. Study on the fragrant volatilized constituents of Cistus ladanifer. fenxi ceshi tongbao, 1991, vol. 10, no. 2, p. 12–18. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

circulating purging and absorption device with Amberlite XAD-4 as adsorbent and analyzed by GC-Fourier transform IR and GC temp. programmed retention index data on dual columns (OV-101 and PEG-20M)
Substance:

iso-pinocamphone (RF-00003875-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Analytical method - additional description:

circulating purging and absorption device with Amberlite XAD-4 as adsorbent and analyzed by GC-Fourier transform IR and GC temp. programmed retention index data on dual columns (OV-101 and PEG-20M)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

10.6
Internal remarks:

isopinocamphone in leaves and twigs

Composition #2: Li, Guang., Zheng, Yaoqing., Sun, Yiliang., Liu, Mixin., Wu, Zhuping. Study on the fragrant volatilized constituents of Cistus ladanifer. fenxi ceshi tongbao, 1991, vol. 10, no. 2, p. 12–18. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

circulating purging and absorption device with Amberlite XAD-4 as adsorbent and analyzed by GC-Fourier transform IR and GC temp. programmed retention index data on dual columns (OV-101 and PEG-20M)
Substance:

Toluene (RF-00004852-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Analytical method - additional description:

circulating purging and absorption device with Amberlite XAD-4 as adsorbent and analyzed by GC-Fourier transform IR and GC temp. programmed retention index data on dual columns (OV-101 and PEG-20M)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

7.6
Internal remarks:

toluene in leaves and twigs

Composition #3: Li, Guang., Zheng, Yaoqing., Sun, Yiliang., Liu, Mixin., Wu, Zhuping. Study on the fragrant volatilized constituents of Cistus ladanifer. fenxi ceshi tongbao, 1991, vol. 10, no. 2, p. 12–18. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

circulating purging and absorption device with Amberlite XAD-4 as adsorbent and analyzed by GC-Fourier transform IR and GC temp. programmed retention index data on dual columns (OV-101 and PEG-20M)
Substance:

Naphthalene derivatives (RF-00010833-PAR)
Additional substance description:

naphthalene
Analytical method code:

Gaschromatography (GC) (F037A)
Analytical method - additional description:

circulating purging and absorption device with Amberlite XAD-4 as adsorbent and analyzed by GC-Fourier transform IR and GC temp. programmed retention index data on dual columns (OV-101 and PEG-20M)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.5
Internal remarks:

naphthalene in leaves and twigs

Composition #4: Chaves, N., Sosa, T., Alias, JC., Escudero, JC. Identification and effects of interaction phytotoxic compounds from exudate of cistus ladanifer leaves . journal of chemical ecology, 2001, vol. 27, no. 3, p. 611–621. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

p-coumaric acid (RF-00010717-PAR)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

coumaric acid in leaves GS-MS

Composition #5: Chaves, N., Sosa, T., Alias, JC., Escudero, JC. Identification and effects of interaction phytotoxic compounds from exudate of cistus ladanifer leaves . journal of chemical ecology, 2001, vol. 27, no. 3, p. 611–621. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

oxalic acid (RF-00000356-NTR)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

oxalic acid in leaves GC-MS

Composition #6: Chaves, N., Sosa, T., Alias, JC., Escudero, JC. Identification and effects of interaction phytotoxic compounds from exudate of cistus ladanifer leaves . journal of chemical ecology, 2001, vol. 27, no. 3, p. 611–621. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

4-Hydroxybenzoic acid (RF-00008325-PAR)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

4-Hydroxybenzoic acid in leaves GC-MS

Composition #7: Herranz, Jose M., Ferrandis, Pablo., Copete, Miguel A., Duro, Esmeralda M., Zalacain, Amaya. Effect of allelopathic compounds produced by Cistus ladanifer on germination of 20 Mediterranean taxa . plant ecology, 2006, vol. 184, no. 2, p. 259–272. DOI: 10.1007/s11258-005-9071-6. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

4-Hydroxybenzoic acid (RF-00008325-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

4-hydroxybenzoic acid, leaves, HPLC

Composition #8: Herranz, Jose M., Ferrandis, Pablo., Copete, Miguel A., Duro, Esmeralda M., Zalacain, Amaya. Effect of allelopathic compounds produced by Cistus ladanifer on germination of 20 Mediterranean taxa . plant ecology, 2006, vol. 184, no. 2, p. 259–272. DOI: 10.1007/s11258-005-9071-6. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

p-coumaric acid (RF-00010717-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

p-coumaric acid, leaves, HPLC

Composition #9: Herranz, Jose M., Ferrandis, Pablo., Copete, Miguel A., Duro, Esmeralda M., Zalacain, Amaya. Effect of allelopathic compounds produced by Cistus ladanifer on germination of 20 Mediterranean taxa . plant ecology, 2006, vol. 184, no. 2, p. 259–272. DOI: 10.1007/s11258-005-9071-6. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

gallic acid, leaves, HPLC

Composition #10: Herranz, Jose M., Ferrandis, Pablo., Copete, Miguel A., Duro, Esmeralda M., Zalacain, Amaya. Effect of allelopathic compounds produced by Cistus ladanifer on germination of 20 Mediterranean taxa . plant ecology, 2006, vol. 184, no. 2, p. 259–272. DOI: 10.1007/s11258-005-9071-6. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

2-(4-Hydroxyphenyl)ethan-1-ol (RF-00002233-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tyrosol, leaves, HPLC

Composition #11: Teixeira, Salome., Mendes, Adelio., Alves, Arminda., Santos, Lucia. Simultaneous distillation-extraction of high-value volatile compounds from Cistus ladanifer L. . analytica chimica acta, 2007, vol. 584, no. 2, p. 439–446. DOI: 10.1016/j.aca.2006.11.054. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

pentane
Substance:

2,2,6-Trimethylcyclohexanone (RF-00002268-PAR)
Analytical method code:

GC-FID (F040A)
Analytical method - additional description:

HS-SPME
Result unit:

Microgram/litre (G051A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

25-250.4
Internal remarks:

2,2,6-Trimethylcyclohexanone, leaves, GC-FID

Composition #12: Dentinho, M. T. P., Moreira, O. C., Pereira, M. S., Bessa, R. J. B. The use of a tannin crude extract from Cistus ladanifer L. to protect soya-bean protein from degradation in the rumen . animal, 2007, vol. 1, no. 5, p. 645–650. DOI: 10.1017/S1751731107689745. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

aceton and water
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Traditional analytical techniques (wet chemical tests) (F003A)
Result unit:

Gram/kilogram (G015A)
Result expression:

Dry matter (B002A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

300
Internal remarks:

tannins, aerial part of plant, we chemical test

Composition #13: Viuda-Martos, Manuel., Sendra, Esther., Perez-Alvarez, Jose A., Fernandez-Lopez, Juana., Amensour, Mahassine., Abrini, Jamal. Identification of Flavonoid Content and Chemical Composition of the Essential Oils of Moroccan Herbs: Myrtle (Myrtus communis L.), Rockrose (Cistus ladanifer L.) and Montpellier cistus (Cistus monspeliensis L.) . journal of essential oil research, 2011, vol. 23, no. 2, p. 1–9. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

HPLC
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

19.3
Internal remarks:

1,8-cineol, leaves, gc-ms

Composition #14: Chaves, N., Sosa, T., Valares, C., Alias, J. C. Routes of incorporation of phytotoxic compounds of Cistus ladanifer L. into soil . allelopathy journal, 2015, vol. 36, no. 1, p. 25–36. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

throughfall
Substance:

Diterpenes Diterpenes (RF-00004378-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

diterpenes, leaves throughfall, HPLC

Composition #15: Morales, Rodrigo., Ungerfeld, Emilio M. Use of tannins to improve fatty acids profile of meat and milk quality in ruminants: A review . chilean journal of agricultural research, 2015, vol. 75, no. 2, p. 239–248. DOI: 10.4067/S0718-58392015000200014. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Substance:

Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.5-16.3
Internal remarks:

protoanthocyanidins, aerial part of plants