Draft - work in progress
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- Cissampelos pareira L. // Cissampelos pareira var. hirsuta (Buch.-Ham. ex DC.) Forman
Cissampelos pareira L. // Cissampelos pareira var. hirsuta (Buch.-Ham. ex DC.) Forman
- Family:
- Menispermaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 332
- Number of processed references:
- 9
Composition #1: Mukerji, B., Bhandari, P. R. Cissampelos pareira, source of a new curariform drug. planta medica, 1959, vol. 7, p. 250–9. .
[
DOI link]
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Substance:
Calcium oxalate (RF-00003960-PAR)
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Analytical method code:
Microscopic detection (F536A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
calcium oxalate in roots
Composition #2: Mukerji, B., Bhandari, P. R. Cissampelos pareira, source of a new curariform drug. planta medica, 1959, vol. 7, p. 250–9. .
[
DOI link]
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Substance:
hayatine (RF-00003858-PAR)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
hayatine in roots
Composition #3: Sudhakaran, M.V. Histo-morphological, fluorescent and powder microscopic characterization of Cissampelos pareira Linn.. pharmacognosy journal, 2012, vol. 4, no. 34, p. 57–68. DOI: 10.5530/pj.2012.34.11.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Substance:
Calcium oxalate (RF-00003960-PAR)
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Analytical method code:
Microscopic detection (F536A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
calcium oxalate in leaf
Composition #4: Ganguly, Mausumi., Borthakur, Mridul Kr., Devi, Nirada., Mahanta, Rita. Antifertility activity of the methanolic leaf extract of Cissampelos pareira in female albino mice . journal of ethnopharmacology, 2007, vol. 111, no. 3, p. 688–691. DOI: 10.1016/j.jep.2007.01.023.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol extraction
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Substance:
Alkaloids (RF-00004360-PAR)
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Analytical method code:
Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
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Analytical method - additional description:
Phytochemical screening
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
alkaloids in leaves
Composition #5: Hullatti, K. K., Sharada, M. S. Comparative phytochemical investigation of the sources of ayurvedic drug Patha: A chromatographic fingerprinting analysis . indian journal of pharmaceutical sciences, 2010, vol. 72, no. 1, p. 39–45. .
[
DOI link]
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
alcohol extraction
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Substance:
Tannins (RF-00004337-PAR)
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Analytical method code:
Unspecified (F598A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
14.78
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Internal remarks:
tannins in roots
Composition #6: Hullatti, K. K., Sharada, M. S. Comparative phytochemical investigation of the sources of ayurvedic drug Patha: A chromatographic fingerprinting analysis . indian journal of pharmaceutical sciences, 2010, vol. 72, no. 1, p. 39–45. .
[
DOI link]
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
alcohol extraction
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Substance:
Alkaloids (RF-00004360-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
6.61
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Internal remarks:
alkaloids in roots
Composition #7: Hullatti, K. K., Sharada, M. S. Comparative phytochemical investigation of the sources of ayurvedic drug Patha: A chromatographic fingerprinting analysis . indian journal of pharmaceutical sciences, 2010, vol. 72, no. 1, p. 39–45. .
[
DOI link]
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
alcohol extraction
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Substance:
1-bebeerine (RF-00004118-PAR)
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Additional substance description:
bebeerine
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Analytical method code:
Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
bebeerine in roots
Composition #8: ANWER, F., POPLI, SP., SRIVASTA.RM., KHARE, MP. STUDIES IN MEDICINAL PLANTS .3. PROTOBERBERINE ALKALOIDS FROM ROOTS OF CISSAMPELOS PAREIRA LINN . experientia, 1968, vol. 24, no. 10, p. 999–&. DOI: 10.1007/BF02138704.
[
DOI link]
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Substance:
Isoquinoline alkaloids (RF-00004391-PAR)
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Additional substance description:
cissamine = cyclanoline
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Analytical method code:
Element spectroscopy (F051A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
isoquinoline alkaloid (cissamine) in roots
Composition #9: MORITA, H., MATSUMOTO, K., TAKEYA, K., ITOKAWA, H. AZAFLUORANTHENE ALKALOIDS FROM CISSAMPELOS-PAREIRA. chemical & pharmaceutical bulletin, 1993, vol. 41, no. 7, p. 1307–1308. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol extraction
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Substance:
Alkaloids (RF-00004360-PAR)
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Additional substance description:
norimeluteine
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
alkaloid (norimeluteine) in roots and wood
Composition #10: MORITA, H., MATSUMOTO, K., TAKEYA, K., ITOKAWA, H. AZAFLUORANTHENE ALKALOIDS FROM CISSAMPELOS-PAREIRA. chemical & pharmaceutical bulletin, 1993, vol. 41, no. 7, p. 1307–1308. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol extraction
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Substance:
Isoquinoline alkaloids (RF-00004391-PAR)
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Additional substance description:
norruffscine
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Isoquinoline alkaloid (norruffscine) in roots and wood
Composition #11: MORITA, H., MATSUMOTO, K., TAKEYA, K., ITOKAWA, H., IITAKA, Y. STRUCTURES AND SOLID-STATE TAUTOMERIC FORMS OF 2 NOVEL ANTILEUKEMIC TROPOLOISOQUINOLINE ALKALOIDS, PAREIRUBRINE-A AND PAREIRUBRINE-B, FROM CISSAMPELOS-PAREIRA . chemical & pharmaceutical bulletin, 1993, vol. 41, no. 8, p. 1418–1422. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol extraction
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Substance:
pareirubrine A (RF-00003975-PAR)
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
pareirubrine A in roots and wood
Composition #12: MORITA, H., MATSUMOTO, K., TAKEYA, K., ITOKAWA, H., IITAKA, Y. STRUCTURES AND SOLID-STATE TAUTOMERIC FORMS OF 2 NOVEL ANTILEUKEMIC TROPOLOISOQUINOLINE ALKALOIDS, PAREIRUBRINE-A AND PAREIRUBRINE-B, FROM CISSAMPELOS-PAREIRA . chemical & pharmaceutical bulletin, 1993, vol. 41, no. 8, p. 1418–1422. .
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-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol extraction
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Substance:
pareirubrine B (RF-00003976-PAR)
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
pareirubrine B in roots and wood
Composition #13: MORITA, H., MATSUMOTO, K., TAKEYA, K., ITOKAWA, H., IITAKA, Y. STRUCTURES AND SOLID-STATE TAUTOMERIC FORMS OF 2 NOVEL ANTILEUKEMIC TROPOLOISOQUINOLINE ALKALOIDS, PAREIRUBRINE-A AND PAREIRUBRINE-B, FROM CISSAMPELOS-PAREIRA . chemical & pharmaceutical bulletin, 1993, vol. 41, no. 8, p. 1418–1422. .
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol extraction
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Substance:
Isoquinoline alkaloids (RF-00004391-PAR)
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Additional substance description:
grandirubrine
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
isoquinoline alkaloid (grandirubrine) in roots and wood
Composition #14: MORITA, H., MATSUMOTO, K., TAKEYA, K., ITOKAWA, H., IITAKA, Y. STRUCTURES AND SOLID-STATE TAUTOMERIC FORMS OF 2 NOVEL ANTILEUKEMIC TROPOLOISOQUINOLINE ALKALOIDS, PAREIRUBRINE-A AND PAREIRUBRINE-B, FROM CISSAMPELOS-PAREIRA . chemical & pharmaceutical bulletin, 1993, vol. 41, no. 8, p. 1418–1422. .
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-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol extraction
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Substance:
Isoquinoline alkaloids (RF-00004391-PAR)
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Additional substance description:
isoimerubrine
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
isoquinoline alkaloid (isomeirubrine) in roots and wood
Composition #15: MORITA, H., TAKEYA, K., ITOKAWA, H. A NOVEL CONDENSED TROPONE-ISOQUINOLINE ALKALOID, PAREITROPONE, FROM CISSAMPELOS-PAREIRA . bioorganic & medicinal chemistry letters, 1995, vol. 5, no. 6, p. 597–598. DOI: 10.1016/0960-894X(95)00068-5.
[
DOI link]
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol extraction
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Substance:
Isoquinoline alkaloids (RF-00004391-PAR)
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Additional substance description:
pareitropone
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Analytical method - additional description:
and by silica gel column chromatography
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.0004
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Internal remarks:
Isoquinoline alkaloid (pareitropone) in roots
Endpoint study
#1: Junaimuang, T., Luangpirom, A., Somsapt, P. Antiepileptic “antifertility properties of Cissampelos pareira Linn. leaf gel in male and female mice”. international journal of phytomedicine, 2015, vol. 7, no. 1, p. 112–118. .
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Study relevance:
Human health
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Plant part:
Leaves (as part-nature) (A0EKT)
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Preparation/Extraction method:
Drying (dehydration) (A07KG)
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Additional plant/substance description:
powdering, reconstituted with distilled water to reform as gel
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Type of toxicological test:
reproduction toxicity (CHD009TT)
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Tested organism:
House mouse (as animal) (A0CNT)
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Strain of test organism:
ICR (CHD044ST)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
10
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligrams per kilogram body weight per day (G211A)
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Effect concentration:
400-600
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Critical effect:
REPRODUCTIVE (TOX05A)
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Target tissue:
Urogenital (TT006A)
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Effect description:
pregnant females - antifertility effect (but not dose-dependent) - inhibition of embryo implantation and inhibits ovulation in females, decreases fertility index by increasing prolactin in pregnant mice
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Effect or parameter linked to the endpoint:
reproduction (CHD014BE)
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Internal remarks:
pregnant females - antifertility effect
Endpoint study
#2: Junaimuang, T., Luangpirom, A., Somsapt, P. Antiepileptic “antifertility properties of Cissampelos pareira Linn. leaf gel in male and female mice”. international journal of phytomedicine, 2015, vol. 7, no. 1, p. 112–118. .
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Study relevance:
Human health
-
Plant part:
Leaves (as part-nature) (A0EKT)
-
Preparation/Extraction method:
Drying (dehydration) (A07KG)
-
Additional plant/substance description:
powdering, reconstituted with distilled water to reform as gel
-
Type of toxicological test:
reproduction toxicity (CHD009TT)
-
Tested organism:
House mouse (as animal) (A0CNT)
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Strain of test organism:
ICR (CHD044ST)
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-
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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-
Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
30
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligrams per kilogram body weight per day (G211A)
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Effect concentration:
100-300
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Critical effect:
REPRODUCTIVE (TOX05A)
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Target tissue:
Urogenital (TT006A)
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Effect description:
males - antifertility effect - disturbance of blood prolactin and testosterone levels, affecting spermatogenesis and impaired sperm quality,
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Effect or parameter linked to the endpoint:
reproduction (CHD014BE)
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Internal remarks:
males - antifertility effect - impairment of sperm quality
Endpoint study
#3: Ganguly, Mausumi., Borthakur, Mridul Kr., Devi, Nirada., Mahanta, Rita. Antifertility activity of the methanolic leaf extract of Cissampelos pareira in female albino mice . journal of ethnopharmacology, 2007, vol. 111, no. 3, p. 688–691. DOI: 10.1016/j.jep.2007.01.023.
[
DOI link]
-
Study relevance:
Human health
-
Plant part:
Leaves (as part-nature) (A0EKT)
-
Preparation/Extraction method:
Solvent extraction (A0BZR)
-
Additional plant/substance description:
methanol extractin
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Type of toxicological test:
reproduction toxicity (CHD009TT)
-
Tested organism:
House mouse (as animal) (A0CNT)
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Strain of test organism:
Swiss (CHD005ST)
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-
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
-
-
Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
15
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-
Endpoint measured:
Dose level (CHD014EP)
-
Concentration unit:
Milligram/kilogram (G061A)
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Effect concentration:
250-450
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Critical effect:
REPRODUCTIVE (TOX05A)
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Target tissue:
Urogenital (TT006A)
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Effect description:
antifertility effect- altered the estrous cycle pattern and reduced the levels of serum hormones (estradiol and LH)
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Effect or parameter linked to the endpoint:
reproduction (CHD014BE)
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Internal remarks:
altered estrous cycle and hormone levels in female mice
Endpoint study
#4: Ganguly, Mausumi., Borthakur, Mridul Kr., Devi, Nirada., Mahanta, Rita. Antifertility activity of the methanolic leaf extract of Cissampelos pareira in female albino mice . journal of ethnopharmacology, 2007, vol. 111, no. 3, p. 688–691. DOI: 10.1016/j.jep.2007.01.023.
[
DOI link]
-
Study relevance:
Human health
-
Plant part:
Leaves (as part-nature) (A0EKT)
-
Preparation/Extraction method:
Solvent extraction (A0BZR)
-
Additional plant/substance description:
methanol extractin
-
Type of toxicological test:
reproduction toxicity (CHD009TT)
-
Tested organism:
House mouse (as animal) (A0CNT)
-
Strain of test organism:
Swiss (CHD005ST)
-
-
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
-
-
Unit of exposure duration:
Day (G134A)
-
Number of organisms dosed:
15
-
-
Endpoint measured:
Dose level (CHD014EP)
-
Concentration unit:
Milligrams per kilogram body weight per day (G211A)
-
Effect concentration:
250-450
-
Critical effect:
REPRODUCTIVE (TOX05A)
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Target tissue:
Urogenital (TT006A)
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Effect description:
reduced number of litters
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Effect or parameter linked to the endpoint:
reproduction (CHD014BE)
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Internal remarks:
reduced number of litters