Draft - work in progress
-
- cinchona pubescens
- Red cinchona (infusion bark) // Cinchona pubescens Vahl // Cinchona succirubra Pav. ex Klotzsch
Red cinchona (infusion bark) // Cinchona pubescens Vahl // Cinchona succirubra Pav. ex Klotzsch
- Family:
- Rubiaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 228
- Number of processed references:
- 3
Composition #1: Staba, E. John., Chung, Alex C. Quinine and quinidine production by cinchona leaf, root and unorganized cultures. phytochemistry (elsevier), 1981, vol. 20, no. 11, p. 2495–8. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
benzene
-
Substance:
cinchonidine (RF-00003740-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Analytical method - additional description:
TLC, GC, HPLC
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.10
-
Internal remarks:
cinchonidine in roots
Composition #2: Staba, E. John., Chung, Alex C. Quinine and quinidine production by cinchona leaf, root and unorganized cultures. phytochemistry (elsevier), 1981, vol. 20, no. 11, p. 2495–8. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
benzene
-
Substance:
quinidine (RF-00004021-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Analytical method - additional description:
TLC, GC, HPLC
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.01
-
Internal remarks:
quinidine in leaf-stem
Composition #3: Staba, E. John., Chung, Alex C. Quinine and quinidine production by cinchona leaf, root and unorganized cultures. phytochemistry (elsevier), 1981, vol. 20, no. 11, p. 2495–8. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
benzene
-
Substance:
cinchonine (RF-00003741-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Analytical method - additional description:
TLC, GC, HPLC
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.27
-
Internal remarks:
cinchonine in roots
Composition #4: Staba, E. John., Chung, Alex C. Quinine and quinidine production by cinchona leaf, root and unorganized cultures. phytochemistry (elsevier), 1981, vol. 20, no. 11, p. 2495–8. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
benzene
-
Substance:
quinine (RF-00004022-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Analytical method - additional description:
TLC, GC, HPLC
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.13
-
Internal remarks:
quinine in roots
Composition #5: Staba, E. John., Chung, Alex C. Quinine and quinidine production by cinchona leaf, root and unorganized cultures. phytochemistry (elsevier), 1981, vol. 20, no. 11, p. 2495–8. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
benzene
-
Substance:
cinchonidine (RF-00003740-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Analytical method - additional description:
TLC, GC, HPLC
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.06
-
Internal remarks:
cinchonidine in leaf-stem
Composition #6: Staba, E. John., Chung, Alex C. Quinine and quinidine production by cinchona leaf, root and unorganized cultures. phytochemistry (elsevier), 1981, vol. 20, no. 11, p. 2495–8. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
benzene
-
Substance:
cinchonine (RF-00003741-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Analytical method - additional description:
TLC, GC, HPLC
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.10
-
Internal remarks:
cinchonine in leaf-stem
Composition #7: Staba, E. John., Chung, Alex C. Quinine and quinidine production by cinchona leaf, root and unorganized cultures. phytochemistry (elsevier), 1981, vol. 20, no. 11, p. 2495–8. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
benzene
-
Substance:
quinine (RF-00004022-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Analytical method - additional description:
TLC, GC, HPLC
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.07
-
Internal remarks:
quinine in leaf-stem
Composition #8: Staba, E. John., Chung, Alex C. Quinine and quinidine production by cinchona leaf, root and unorganized cultures. phytochemistry (elsevier), 1981, vol. 20, no. 11, p. 2495–8. .
-
-
Plant part:
Roots and other underground parts (as part-nature) (A067M)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
benzene
-
Substance:
quinidine (RF-00004021-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Analytical method - additional description:
TLC, GC, HPLC
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.05
-
Internal remarks:
quinidine in roots
Composition #9: Fabiano-Tixier, Anne-Sylvie., Elomri, Abdelhakim., Blanckaert, Axelle., Seguin, Elisabeth., Petitcolas, Emmanuel., Chemat, Farid. Rapid and Green Analytical Method for the Determination of Quinoline Alkaloids from Cinchona succirubra Based on Microwave-Integrated Extraction and Leaching (MIEL) Prior to High Performance Liquid Chromatography . international journal of molecular sciences, 2011, vol. 12, no. 11, p. 7846–7860. DOI: 10.3390/ijms12117846.
[
DOI link]
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-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
calcium hydroxicde and sodium hydroxide (5%)
-
Substance:
cinchonidine (RF-00003740-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Result unit:
Percent (G138A)
-
Result expression:
Reconstituted product (B007A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
22
-
Internal remarks:
cinchonidine in bark
Composition #10: Fabiano-Tixier, Anne-Sylvie., Elomri, Abdelhakim., Blanckaert, Axelle., Seguin, Elisabeth., Petitcolas, Emmanuel., Chemat, Farid. Rapid and Green Analytical Method for the Determination of Quinoline Alkaloids from Cinchona succirubra Based on Microwave-Integrated Extraction and Leaching (MIEL) Prior to High Performance Liquid Chromatography . international journal of molecular sciences, 2011, vol. 12, no. 11, p. 7846–7860. DOI: 10.3390/ijms12117846.
[
DOI link]
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
calcium hydroxicde and sodium hydroxide (5%)
-
Substance:
quinine (RF-00004022-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Result unit:
Percent (G138A)
-
Result expression:
Reconstituted product (B007A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
15
-
Internal remarks:
quinine in bark
Composition #11: Fabiano-Tixier, Anne-Sylvie., Elomri, Abdelhakim., Blanckaert, Axelle., Seguin, Elisabeth., Petitcolas, Emmanuel., Chemat, Farid. Rapid and Green Analytical Method for the Determination of Quinoline Alkaloids from Cinchona succirubra Based on Microwave-Integrated Extraction and Leaching (MIEL) Prior to High Performance Liquid Chromatography . international journal of molecular sciences, 2011, vol. 12, no. 11, p. 7846–7860. DOI: 10.3390/ijms12117846.
[
DOI link]
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
calcium hydroxicde and sodium hydroxide (5%)
-
Substance:
cinchonine (RF-00003741-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Result unit:
Percent (G138A)
-
Result expression:
Reconstituted product (B007A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
37
-
Internal remarks:
cinchonine in bark
Composition #12: Fabiano-Tixier, Anne-Sylvie., Elomri, Abdelhakim., Blanckaert, Axelle., Seguin, Elisabeth., Petitcolas, Emmanuel., Chemat, Farid. Rapid and Green Analytical Method for the Determination of Quinoline Alkaloids from Cinchona succirubra Based on Microwave-Integrated Extraction and Leaching (MIEL) Prior to High Performance Liquid Chromatography . international journal of molecular sciences, 2011, vol. 12, no. 11, p. 7846–7860. DOI: 10.3390/ijms12117846.
[
DOI link]
-
-
Plant part:
Bark (as part-nature) (A066X)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
calcium hydroxicde and sodium hydroxide (5%)
-
Substance:
quinidine (RF-00004021-PAR)
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Result unit:
Percent (G138A)
-
Result expression:
Reconstituted product (B007A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
2.9
-
Internal remarks:
quinidine in bark
Endpoint study
#1: Durasnel, P., Vanhuffel, L., Blonde, R., Lion, F., Galas, T., Mousset-Hovaere, M., Balay, I., Viscardi, G., Valyi, L. Severe poisoning by plants used for traditional medicine in Mayotte .. bulletin de la societe de pathologie exotique (1990), 2014, vol. 107, no. 5, p. 306–11. DOI: 10.1007/s13149-014-0400-7.
[
DOI link]
-
Study relevance:
Human health
-
Preparation/Extraction method:
Solvent extraction (A0BZR)
-
Additional plant/substance description:
water
-
Type of toxicological test:
case report (CHD060TT)
-
Tested organism:
Human (as organism) (A056J)
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-
Route of exposure:
ORAL: DRINKING WATER (OECD2229PL)
-
-
Unit of exposure duration:
Meal (G109A)
-
Number of organisms dosed:
1
-
Control groups used:
no data
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Target tissue:
cardiovascular / haematological: Heart (TT011A)
-
Effect description:
cardiac symptoms
-
Effect or parameter linked to the endpoint:
food consumption (CHD007BE)
-
Internal remarks:
cardiac symptoms after consumption of tisane of leaves and stems (case report)