EFSA Compendium of Botanicals

Draft - work in progress

Chondrodendron tomentosum Ruiz & Pav.

Family:: Menispermaceae
Approval state:: Approved
Number of articles retrieved:: 54
Number of processed references:: 4

Compositions

#1: Tubocurarine in unspecified part #2: 12-O-methyl-(+)-curine in bark #3: alkaloids in bark #4: chondrocurine in bark #5: cycleanine in bark #6: d-Tubocurarinein stem and bark #7: d-isochondodendrine in stem and bark #8: d-chondocurarine, d-chondocurine, d-tubocurarine in unspecified part

Endpoint Studies

Genotoxicity

Composition #1: Salakhutdinov, N. F., Tolstikov, A. Diquaternized Curarelike Myorelaxants: Structure and Biological Activity. mini-reviews in medicinal chemistry, 2010, vol. 10, no. 13, p. 1248–1262. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

Tubocurarine
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tubocurarine in unspecified part

Composition #2: Gonzalez-Coloma, Azucena., Reina, Matias., Saenz, Claudia., Lacret, Rodney., Ruiz-Mesia, Lastenia., Aran, Vicente J., Sanz, Jesus., Martinez-Diaz, Rafael A. Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants . parasitology research, 2012, vol. 110, no. 4, p. 1381–1392. DOI: 10.1007/s00436-011-2638-3. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

12-O-methyl-(+)-curine
Analytical method code:

Gaschromatography (GC) (F037A)
Analytical method - additional description:

UV, IR, GC-MS, NMR
Result unit:

Milligram/100 gram (G057A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.2
Internal remarks:

12-O-methyl-(+)-curine in bark

Composition #3: Gonzalez-Coloma, Azucena., Reina, Matias., Saenz, Claudia., Lacret, Rodney., Ruiz-Mesia, Lastenia., Aran, Vicente J., Sanz, Jesus., Martinez-Diaz, Rafael A. Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants . parasitology research, 2012, vol. 110, no. 4, p. 1381–1392. DOI: 10.1007/s00436-011-2638-3. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Analytical method - additional description:

UV, IR, GC-MS, NMR
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.25
Internal remarks:

alkaloids in bark

Composition #4: Gonzalez-Coloma, Azucena., Reina, Matias., Saenz, Claudia., Lacret, Rodney., Ruiz-Mesia, Lastenia., Aran, Vicente J., Sanz, Jesus., Martinez-Diaz, Rafael A. Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants . parasitology research, 2012, vol. 110, no. 4, p. 1381–1392. DOI: 10.1007/s00436-011-2638-3. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

chondrocurine (RF-00004206-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Analytical method - additional description:

UV, IR, GC-MS, NMR
Result unit:

Milligram/100 gram (G057A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.485
Internal remarks:

chondrocurine in bark

Composition #5: Gonzalez-Coloma, Azucena., Reina, Matias., Saenz, Claudia., Lacret, Rodney., Ruiz-Mesia, Lastenia., Aran, Vicente J., Sanz, Jesus., Martinez-Diaz, Rafael A. Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants . parasitology research, 2012, vol. 110, no. 4, p. 1381–1392. DOI: 10.1007/s00436-011-2638-3. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

cycleanine (RF-00004243-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Analytical method - additional description:

UV, IR, GC-MS, NMR
Result unit:

Milligram/100 gram (G057A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.757
Internal remarks:

cycleanine in bark

Composition #6: DUTCHER, JD. CURARE ALKALOIDS FROM CHONDODENDRON-TOMENTOSUM, RUIZ AND PAVON. journal of the american chemical society, 1946, vol. 68, no. 3, p. 419–424. DOI: 10.1021/ja01207a022. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

aqueous extract (from stem and bark)
Substance:

D-tubocurarine (RF-00004282-PAR)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

d-Tubocurarinein stem and bark

Composition #7: DUTCHER, JD. CURARE ALKALOIDS FROM CHONDODENDRON-TOMENTOSUM, RUIZ AND PAVON. journal of the american chemical society, 1946, vol. 68, no. 3, p. 419–424. DOI: 10.1021/ja01207a022. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

aqueous extract (from stem and bark)
Substance:

D-isochondodendrine (RF-00004083-PAR)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

d-isochondodendrine in stem and bark

Composition #8: DUTCHER, JD. THE ISOLATION AND IDENTIFICATION OF ADDITIONAL PHYSIOLOGICALLY ACTIVE ALKALOIDS IN EXTRACTS OF CHONDODENDRON-TOMENTOSUM RUIZ AND PAVON . annals of the new york academy of sciences, 1951, vol. 54, no. 3, p. 326–356. DOI: 10.1111/j.1749-6632.1951.tb39928.x. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCL3 + water
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

d-chondocurarine, d-chondocurine, d-tubocurarine
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

d-chondocurarine, d-chondocurine, d-tubocurarine in unspecified part