EFSA Compendium of Botanicals

Draft - work in progress

Dysphania chilensis (Schrad.) Mosyakin & Clemants // Chenopodium ambrosioides var. anthelminticum (L.) A.Gray

Family:: Amaranthaceae
Approval state:: Approved
Number of articles retrieved:: 16
Number of processed references:: 5

Compositions

#1: Ascaridol in aerial parts #2: d-camphor in essential oil of Dysphania chilensis #3: Plants grown in South Australia and N. S. W. were collected when close to maturity, cured by air-drying and steam distilled. The yield of oil was 0.3-0.5% of the fresh green wight of the whole plant . The contents of ascaridole in the oils obtained from Chenopodium ambrosoides (Linn.) var. anthelmiticum (Gray), grown under different conditions and determined with different methodologies, varied between 44.4 and 90%. #4: The ascaridol oil in the fruit is present 59-69% in the calyx and 31-41% in the pericarp #5: Ascaridole (0.7%) and benzaldehyde (0.1%) were detected in leaves #6: Ascaridol in essential oil

Endpoint Studies

Genotoxicity

Composition #1: Wirth, Elmer Hauser. A study of Chenopodium ambrosioides, Var. anthelminticum. and its volatile oil. journal of the american pharmaceutical association (1912-1977), 1920, vol. 9, p. 127–41. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

ascaridol (RF-00004159-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

42-45
Internal remarks:

Ascaridol in aerial parts

Composition #2: Wirth, Elmer Hauser. A study of Chenopodium ambrosioides, Var. anthelminticum. and its volatile oil. journal of the american pharmaceutical association (1912-1977), 1920, vol. 9, p. 127–41. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

(-)-camphor (RF-00003469-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

d-camphor in essential oil of Dysphania chilensis

Composition #3: Shapter, R. E. A preliminary investigation of the yield and composition of the oil distilled from Chenopodium ambrosioides (Linn.) var. anthelminticum (Gray). journal of the council for scientific and industrial research (australia), 1941, vol. 14, p. 201–8. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

ascaridol (RF-00004159-PAR)
Result unit:

Gram/100 gram (G013A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

44.4-90.0
Internal remarks:

Plants grown in South Australia and N. S. W. were collected when close to maturity, cured by air-drying and steam distilled. The yield of oil was 0.3-0.5% of the fresh green wight of the whole plant . The contents of ascaridole in the oils obtained from Chenopodium ambrosoides (Linn.) var. anthelmiticum (Gray), grown under different conditions and determined with different methodologies, varied between 44.4 and 90%.

Composition #4: Iwasa, Junzo., Wada, Shusuke., Fukuda, Tomoaki., Katsura, Taeko. Histochemical studies on plant components. II. Distribution of chenopodium oil and ascaridole in American wormseed. japan. j. pharmacognosy, 1954, vol. 1953-1954, 7-8, p. 52–4. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

ascaridol (RF-00004159-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Analytical method - additional description:

unspecified
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

31-69
Internal remarks:

The ascaridol oil in the fruit is present 59-69% in the calyx and 31-41% in the pericarp

Composition #5: Jirovetz, L., Buchbauer, G., Fleischhacker, W., Kaul, V.K. Analysis of the essential oil of the leaves of the medicinal plant Chenopodium ambrosioides var. anthelminticum (L.) A. Gray from India. scientia pharmaceutica, 2000, vol. 68, no. 1, p. 123–128. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

pinocarvone (RF-00003547-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1
Internal remarks:

Ascaridole (0.7%) and benzaldehyde (0.1%) were detected in leaves

Composition #6: Gbolade, Adebayo A., Tira-Picos, Vania., Nogueria, Jose M. F. CHEMICAL CONSTITUENTS OF Chenopodium ambrosioides var. anthelminticum HERB ESSENTIAL OIL FROM NIGERIA . chemistry of natural compounds, 2010, vol. 46, no. 4, p. 654–655. DOI: 10.1007/s10600-010-9704-4. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

ascaridol (RF-00004159-PAR)
Additional substance description:

ascaridole
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.1
Internal remarks:

Ascaridol in essential oil