EFSA Compendium of Botanicals

Draft - work in progress

Cardiospermum halicacabum L.

Family:: Sapindaceae
Approval state:: Approved
Number of articles retrieved:: 351
Number of processed references:: 4

Compositions

#1: Tannins in leaves #2: saponins in leaves #3: calcium oxalate in leaves #4: alkaloids in leaves #5: protocatechualdehyde (3,4-Dihydroxybenzaldehyde) in unspecified plant part #6: calycosin in unspecified plant part #7: protocatechuic acid (3,4-Dihydroxybenzoic acid) in unspecified plant part #8: tannins in roots #9: saponins in roots

Endpoint Studies

#1: Antiimplantation activity in rats #2: Mortality in mice

Genotoxicity

Composition #1: Suhas, S.N., Vilas, D.V. Pharmacognostic evaluation of dried leaf powder of Cardiospermum halicacabum Linn. and dried seed hull powder of Hydnocarpus pentandra (Buch.-Ham.) Oken. international journal of research in ayurveda and pharmacy, 2014, vol. 5, no. 4, p. 502–507. DOI: 10.7897/2277-4343.054102. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins in leaves

Composition #2: Suhas, S.N., Vilas, D.V. Pharmacognostic evaluation of dried leaf powder of Cardiospermum halicacabum Linn. and dried seed hull powder of Hydnocarpus pentandra (Buch.-Ham.) Oken. international journal of research in ayurveda and pharmacy, 2014, vol. 5, no. 4, p. 502–507. DOI: 10.7897/2277-4343.054102. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins in leaves

Composition #3: Suhas, S.N., Vilas, D.V. Pharmacognostic evaluation of dried leaf powder of Cardiospermum halicacabum Linn. and dried seed hull powder of Hydnocarpus pentandra (Buch.-Ham.) Oken. international journal of research in ayurveda and pharmacy, 2014, vol. 5, no. 4, p. 502–507. DOI: 10.7897/2277-4343.054102. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Additional extraction description:

powdering
Substance:

Calcium oxalate (RF-00003960-PAR)
Analytical method code:

Microscopic detection (F536A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

calcium oxalate in leaves

Composition #4: Suhas, S.N., Vilas, D.V. Pharmacognostic evaluation of dried leaf powder of Cardiospermum halicacabum Linn. and dried seed hull powder of Hydnocarpus pentandra (Buch.-Ham.) Oken. international journal of research in ayurveda and pharmacy, 2014, vol. 5, no. 4, p. 502–507. DOI: 10.7897/2277-4343.054102. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

alkaloids in leaves

Composition #5: Chen, Jun., Wei, Jian-Hua., Cai, Shao-Fang., Miao, Wei-Sheng., Pan, Li-Wei. Study on chemical constituents of Cardiospermum halicacabum .. zhong yao cai = zhongyaocai = journal of chinese medicinal materials, 2013, vol. 36, no. 2, p. 228–30. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

3,4-Dihydroxybenzaldehyde (RF-00001977-PAR)
Additional substance description:

protocatechualdehyde
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

protocatechualdehyde (3,4-Dihydroxybenzaldehyde) in unspecified plant part

Composition #6: Chen, Jun., Wei, Jian-Hua., Cai, Shao-Fang., Miao, Wei-Sheng., Pan, Li-Wei. Study on chemical constituents of Cardiospermum halicacabum .. zhong yao cai = zhongyaocai = journal of chinese medicinal materials, 2013, vol. 36, no. 2, p. 228–30. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

calycosin (RF-00004191-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

calycosin in unspecified plant part

Composition #7: Chen, Jun., Wei, Jian-Hua., Cai, Shao-Fang., Miao, Wei-Sheng., Pan, Li-Wei. Study on chemical constituents of Cardiospermum halicacabum .. zhong yao cai = zhongyaocai = journal of chinese medicinal materials, 2013, vol. 36, no. 2, p. 228–30. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

3,4-Dihydroxybenzoic acid (RF-00008853-PAR)
Additional substance description:

syn of protocatechuic acid
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

protocatechuic acid (3,4-Dihydroxybenzoic acid) in unspecified plant part

Composition #8: Dhayabaran, Daniel., Florance, Jeyaseeli., Krsihnadas, Nandakumar., Indumathi., Muralidhar. Anticonvulsant activity of alcoholic root extract of Cardiospermum halicacabum . revista brasileira de farmacognosia-brazilian journal of pharmacognosy, 2012, vol. 22, no. 3, p. 623–629. DOI: 10.1590/S0102-695X2012005000017. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether extraction
Substance:

Tannins (RF-00004337-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tannins in roots

Composition #9: Dhayabaran, Daniel., Florance, Jeyaseeli., Krsihnadas, Nandakumar., Indumathi., Muralidhar. Anticonvulsant activity of alcoholic root extract of Cardiospermum halicacabum . revista brasileira de farmacognosia-brazilian journal of pharmacognosy, 2012, vol. 22, no. 3, p. 623–629. DOI: 10.1590/S0102-695X2012005000017. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether extraction
Substance:

Saponins (RF-00004333-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins in roots

Endpoint study #1: Dhanwad, R., Purohit, M.G., Patil, S., Patil, S.B., Satyanarayan, N.D. Antiimplantation activity of ethanolic extract of cardiospermum halicacabum linn. (sapindaceae) in albino rats. indian drugs, 2005, vol. 42, no. 11, p. 726–730. .

Study relevance:

Human health
Plant part:

Live plants (as part-nature) (A0BA0)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

Ethanol
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Rat (as animal) (A0CNV)
Sex:

Female
Exposure duration:

7.0
Unit of exposure duration:

Day (G134A)
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight (G225A)
Effect concentration:

500
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

60% inhibition of implantation sites
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

Antiimplantation activity in rats

Endpoint study #2: Dhayabaran, Daniel., Florance, Jeyaseeli., Krsihnadas, Nandakumar., Indumathi., Muralidhar. Anticonvulsant activity of alcoholic root extract of Cardiospermum halicacabum . revista brasileira de farmacognosia-brazilian journal of pharmacognosy, 2012, vol. 22, no. 3, p. 623–629. DOI: 10.1590/S0102-695X2012005000017. [DOI link]

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

petroleum ether, ethanol
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Female
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight (G225A)
Effect concentration:

2000
Critical effect:

SYSTEMIC (TOX01A)
Effect description:

Mortality of 67% animals at dose 2000 mg/kg body weight
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

Mortality in mice