Draft - work in progress
-
- cannabis sativa
- Cannabis indica Lam.
Cannabis indica Lam.
- Family:
- Cannabaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 11773
- Number of processed references:
- 8
Endpoint Studies
#1: gidiness, sleepiness, eye deviation (ocular movements were absent)
#2: Neurotoxicity
#3: decreased body weight, heamatological and biochemical changes, organ weight and histopathological findings at dose level 1000 mg/kg/b.w.
#4: mortality at dose level 3000/4000 mg/kg/b.w.
#5: Subchronic toxicity: NOAEL - 100 mg/kg/b.w. for males and 360 mg/kg/b.w. for females
#6: Aggressive behavior in both dosed male and female rats. Other clinical findings: sensitivity to touch, convulsions, lethargy, diarrhea, and tremors, especially in the 150 and 500 mg/kg groups.
#7: Uterine atrophy and ovarian hypoplasia with the 150 and 500 mg/kg groups. Ovarian hypoplasia with a decrease in the size of maturing follicles. Estrous cycle lengths of the 15, 50, 150, and 500mg/kg females significantly longer than in controls
Composition #1: Marselos, Marios., Karamanakos, Petros. Mutagenicity, developmental toxicity and carcinogenicity of cannabis. addiction biology, 1999, vol. 4, no. 1, p. 5–12. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Additional extraction description:
unspecified
-
Substance:
Cannabigerol (RF-00007604-PAR)
-
Additional substance description:
cannabinoids
-
Analytical method - additional description:
unspecified
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
cannabigerol
Composition #2: Marselos, Marios., Karamanakos, Petros. Mutagenicity, developmental toxicity and carcinogenicity of cannabis. addiction biology, 1999, vol. 4, no. 1, p. 5–12. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Additional extraction description:
unspecified
-
Substance:
cannabinoids (RF-00013679-PAR)
-
Additional substance description:
cannabinolic acid, cannabicyclol
-
Analytical method - additional description:
unspecified
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
cannabinolic acid, cannabicyclol
Composition #3: Marselos, Marios., Karamanakos, Petros. Mutagenicity, developmental toxicity and carcinogenicity of cannabis. addiction biology, 1999, vol. 4, no. 1, p. 5–12. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Additional extraction description:
unspecified
-
Substance:
delta-9-Tetrahydrocannabinol (RF-00002598-PAR)
-
Additional substance description:
cannabinoids
-
Analytical method - additional description:
unspecified
-
Result unit:
Percent (G138A)
-
Result expression:
Whole weight (B001A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
1
-
Internal remarks:
delta-9-tetrahydrocannabinol in leaves and flowering tops
Composition #4: Marselos, Marios., Karamanakos, Petros. Mutagenicity, developmental toxicity and carcinogenicity of cannabis. addiction biology, 1999, vol. 4, no. 1, p. 5–12. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Additional extraction description:
unspecified
-
Substance:
Cannabinol (RF-00002601-PAR)
-
Additional substance description:
cannabinoids
-
Analytical method - additional description:
unspecified
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
cannabinol
Composition #5: Marselos, Marios., Karamanakos, Petros. Mutagenicity, developmental toxicity and carcinogenicity of cannabis. addiction biology, 1999, vol. 4, no. 1, p. 5–12. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Additional extraction description:
unspecified
-
Substance:
Cannabidiol (RF-00002600-PAR)
-
Additional substance description:
cannabinoids
-
Analytical method - additional description:
unspecified
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
cannabidiol
Composition #6: Qureshi, Muhammad Nasimullah., Kanwal, Farina., Siddique, Muhammad., Inayat-ur-Rahman., Akram, Muhammad. Estimation of biologically active Cannabinoids in Cannabis indica by gas chromatography-mass spectrometry (GC-MS). world applied sciences journal, 2012, vol. 19, no. 7, p. 918–923. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
n-hexane
-
Substance:
cannabinoids (RF-00013679-PAR)
-
Additional substance description:
delta 9-tetrahydrocannabivarin, cannabivarin, cannabichromene, cannabipinol, cannabigerl, hexahydrocannabinol, cannabinol
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.03-5.14
-
Internal remarks:
Cannabinoids in resin (quantitative)
Composition #7: Qureshi, Muhammad Nasimullah., Kanwal, Farina., Siddique, Muhammad., Inayat-ur-Rahman., Akram, Muhammad. Estimation of biologically active Cannabinoids in Cannabis indica by gas chromatography-mass spectrometry (GC-MS). world applied sciences journal, 2012, vol. 19, no. 7, p. 918–923. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
n-hexane
-
Substance:
delta-9-Tetrahydrocannabinol (RF-00002598-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
1.03-23.84
-
Internal remarks:
delta 9-tetrahydrocannabinol (THC) in resin (quantitative)
Composition #8: Qureshi, Muhammad Nasimullah., Kanwal, Farina., Siddique, Muhammad., Inayat-ur-Rahman., Akram, Muhammad. Estimation of biologically active Cannabinoids in Cannabis indica by gas chromatography-mass spectrometry (GC-MS). world applied sciences journal, 2012, vol. 19, no. 7, p. 918–923. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
n-hexane
-
Substance:
Cannabinol (RF-00002601-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
15.07-67.4
-
Internal remarks:
Cannabinol in resin (quantitative)
Composition #9: Qureshi, Muhammad Nasimullah., Kanwal, Farina., Siddique, Muhammad., Inayat-ur-Rahman., Akram, Muhammad. Estimation of biologically active Cannabinoids in Cannabis indica by gas chromatography-mass spectrometry (GC-MS). world applied sciences journal, 2012, vol. 19, no. 7, p. 918–923. .
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
n-hexane
-
Substance:
Cannabidiol (RF-00002600-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
26.6-54.48
-
Internal remarks:
Cannabidiol in resin (quantitative)
Composition #10: Qureshi, M.N., Kanwal, F., Siddique, M., Inayat-ur-Rahman., Akram, M. Estimation of biologically active cannabinoids in Cannabis indica by Gas Chromatography-mass Spectrometry (GC-MS). world applied sciences journal, 2012, vol. 19, no. 7, p. 918–923. DOI: 10.5829/idosi.wasj.2012.19.07.1922.
[
DOI link]
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
hexane
-
Substance:
delta-9-Tetrahydrocannabinol (RF-00002598-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
23.84
-
Internal remarks:
delta-9-Tetrahydrocannabinol resins
Composition #11: Qureshi, M.N., Kanwal, F., Siddique, M., Inayat-ur-Rahman., Akram, M. Estimation of biologically active cannabinoids in Cannabis indica by Gas Chromatography-mass Spectrometry (GC-MS). world applied sciences journal, 2012, vol. 19, no. 7, p. 918–923. DOI: 10.5829/idosi.wasj.2012.19.07.1922.
[
DOI link]
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
hexane
-
Substance:
Cannabinol (RF-00002601-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
15.07-67.4
-
Internal remarks:
cannabinol resins
Composition #12: Qureshi, M.N., Kanwal, F., Siddique, M., Inayat-ur-Rahman., Akram, M. Estimation of biologically active cannabinoids in Cannabis indica by Gas Chromatography-mass Spectrometry (GC-MS). world applied sciences journal, 2012, vol. 19, no. 7, p. 918–923. DOI: 10.5829/idosi.wasj.2012.19.07.1922.
[
DOI link]
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
hexane
-
Substance:
Cannabigerol (RF-00007604-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.11-0.7
-
Internal remarks:
cannabigerol resins
Composition #13: Qureshi, M.N., Kanwal, F., Siddique, M., Inayat-ur-Rahman., Akram, M. Estimation of biologically active cannabinoids in Cannabis indica by Gas Chromatography-mass Spectrometry (GC-MS). world applied sciences journal, 2012, vol. 19, no. 7, p. 918–923. DOI: 10.5829/idosi.wasj.2012.19.07.1922.
[
DOI link]
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
hexane
-
Substance:
Cannabidiol (RF-00002600-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
26.6-54.48
-
Internal remarks:
cannabidiol resins
Composition #14: Qureshi, M.N., Kanwal, F., Siddique, M., Inayat-ur-Rahman., Akram, M. Estimation of biologically active cannabinoids in Cannabis indica by Gas Chromatography-mass Spectrometry (GC-MS). world applied sciences journal, 2012, vol. 19, no. 7, p. 918–923. DOI: 10.5829/idosi.wasj.2012.19.07.1922.
[
DOI link]
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
hexane
-
Substance:
cannabinoids (RF-00013679-PAR)
-
Additional substance description:
cannaigerl
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.11-0.7
-
Internal remarks:
cannaigerl resins
Composition #15: Qureshi, M.N., Kanwal, F., Siddique, M., Inayat-ur-Rahman., Akram, M. Estimation of biologically active cannabinoids in Cannabis indica by Gas Chromatography-mass Spectrometry (GC-MS). world applied sciences journal, 2012, vol. 19, no. 7, p. 918–923. DOI: 10.5829/idosi.wasj.2012.19.07.1922.
[
DOI link]
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
hexane
-
Substance:
Tetrahydrocannabivarin (RF-00007602-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.03-2.03
-
Internal remarks:
tetrahydrocannabivarin resins
Composition #16: Qureshi, M.N., Kanwal, F., Siddique, M., Inayat-ur-Rahman., Akram, M. Estimation of biologically active cannabinoids in Cannabis indica by Gas Chromatography-mass Spectrometry (GC-MS). world applied sciences journal, 2012, vol. 19, no. 7, p. 918–923. DOI: 10.5829/idosi.wasj.2012.19.07.1922.
[
DOI link]
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
hexane
-
Substance:
cannabinoids (RF-00013679-PAR)
-
Additional substance description:
cannabichromene
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
1.29-4.51
-
Internal remarks:
cannabichromene resins
Composition #17: Qureshi, M.N., Kanwal, F., Siddique, M., Inayat-ur-Rahman., Akram, M. Estimation of biologically active cannabinoids in Cannabis indica by Gas Chromatography-mass Spectrometry (GC-MS). world applied sciences journal, 2012, vol. 19, no. 7, p. 918–923. DOI: 10.5829/idosi.wasj.2012.19.07.1922.
[
DOI link]
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
hexane
-
Substance:
Cannabinol (RF-00002601-PAR)
-
Additional substance description:
hexahydrocannabinol
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.12-0.82
-
Internal remarks:
hexahydrocannabinol resins
Composition #18: Naz, Saima., Hanif, Muhammad Asif., Bhatti, Haq Nawaz., Ansari, Tariq Mahmood. Impact of Supercritical Fluid Extraction and Traditional Distillation on the Isolation of Aromatic Compounds from Cannabis indica and Cannabis sativa . journal of essential oil bearing plants, 2017, vol. 20, no. 1, p. 175–184. DOI: 10.1080/0972060X.2017.1281766.
[
DOI link]
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
hydrodistilation
-
Substance:
Carvone (RF-0538-001-PPP)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result expression:
Reconstituted product (B007A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
2.11-5.13
-
Internal remarks:
carvone aerial parts gc-ms
Composition #19: Naz, Saima., Hanif, Muhammad Asif., Bhatti, Haq Nawaz., Ansari, Tariq Mahmood. Impact of Supercritical Fluid Extraction and Traditional Distillation on the Isolation of Aromatic Compounds from Cannabis indica and Cannabis sativa . journal of essential oil bearing plants, 2017, vol. 20, no. 1, p. 175–184. DOI: 10.1080/0972060X.2017.1281766.
[
DOI link]
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
hydrodistilation
-
Substance:
myrcene (RF-00003503-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result expression:
Reconstituted product (B007A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
1.062-1.81
-
Internal remarks:
myrcene aerial parts gc-ms
Composition #20: Marx, Tennille K., Reddeman, Robin., Clewell, Amy E., Endres, John R., Beres, Erzsebet., Vertesi, Adel., Glavits, Robert., Hirka, Gabor., Szakonyine, Ilona Pasics. An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp. journal of toxicology, 2018 . DOI: 10.1155/2018/8143582.
[
DOI link]
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Super-critical gas extraction (A0BZQ)
-
Additional extraction description:
CO2
-
Substance:
cannabinoids (RF-00013679-PAR)
-
Additional substance description:
96% CBD , < 1% THC
-
Analytical method - additional description:
unspecified
-
Result unit:
Percent (G138A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
26
-
Internal remarks:
Cannabinoids (96% CBD , < 1% THC)
Composition #21: Marx, Tennille K., Reddeman, Robin., Clewell, Amy E., Endres, John R., Beres, Erzsebet., Vertesi, Adel., Glavits, Robert., Hirka, Gabor., Szakonyine, Ilona Pasics. An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp. journal of toxicology, 2018 . DOI: 10.1155/2018/8143582.
[
DOI link]
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Super-critical gas extraction (A0BZQ)
-
Additional extraction description:
CO2
-
Substance:
cannabinoids (RF-00013679-PAR)
-
Additional substance description:
cannabichromene
-
Analytical method - additional description:
unspecified
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
cannabichromene in aerial parts
Endpoint study
#1: MOHAN, H., SOOD, G C. CONJUGATE DEVIATION OF THE EYES AFTER CANNABIS INDICA INTOXICATION.. the british journal of ophthalmology, 1964, vol. 48, p. 160–1. DOI: 10.1136/bjo.48.3.160.
[
DOI link]
-
Study relevance:
Human health
-
Type of toxicological test:
case report (CHD060TT)
-
Tested organism:
Human (as organism) (A056J)
-
-
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
-
Number of organisms dosed:
1
-
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Target tissue:
Neurologic (TT004A)
-
Effect description:
gidiness, sleepiness, eye deviation due to absence of ocular movements (CONJUGATE DEVIATION OF THE EYES)
-
Effect or parameter linked to the endpoint:
neurology (CHD027BE)
-
Internal remarks:
gidiness, sleepiness, eye deviation (ocular movements were absent)
Endpoint study
#2: Favretto, Donata., Montisci, Massimo., Snenghi, Rossella., Andreazza, AC., Scola, G. Forensic Toxicology. toxicology studies - cells, drugs and environment, 2015, p. 85–100. DOI: 10.5772/60445.
[
DOI link]
-
Study relevance:
Human health
-
Substance:
Sum of Tetrahydrocannabinols (RF-00002597-PAR)
-
Type of toxicological test:
acute toxicity (CHD016TT)
-
Endpoint measured:
Dose not reported (CHD066EP)
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Target tissue:
Neurologic (TT004A)
-
Effect description:
rise in systolic pressure, cardiac frequency, conjunctival hyperemia,altered vision, reduction in awareness, delayed reactions to stimuli, anxiety, paranoia, panic attacks, motor coordination deficit, impaired judgement
-
Effect or parameter linked to the endpoint:
neurology (CHD027BE)
-
Internal remarks:
Neurotoxicity
Endpoint study
#3: Marx, Tennille K., Reddeman, Robin., Clewell, Amy E., Endres, John R., Beres, Erzsebet., Vertesi, Adel., Glavits, Robert., Hirka, Gabor., Szakonyine, Ilona Pasics. An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp. journal of toxicology, 2018 . DOI: 10.1155/2018/8143582.
[
DOI link]
-
Study relevance:
Human health
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Preparation/Extraction method:
Super-critical gas extraction (A0BZQ)
-
Additional plant/substance description:
CO2
-
Type of toxicological test:
short-term toxicity (CHD017TT)
-
-
Guideline:
OECD GUIDELINE 407 (REPEATED DOSE 28-DAY ORAL TOXICITY IN RODENTS) (OECD1255PL)
-
Tested organism:
Rat (as animal) (A0CNV)
-
Strain of test organism:
Wistar (CHD013ST)
-
-
Route of exposure:
ORAL: GAVAGE (OECD2231PL)
-
-
Unit of exposure duration:
Day (G134A)
-
Number of organisms dosed:
10
-
Control groups used:
yes, concurrent vehicle
-
Endpoint measured:
Dose level (CHD014EP)
-
Concentration unit:
Milligrams per kilogram body weight (G225A)
-
Effect concentration:
1000
-
Critical effect:
SYSTEMIC (TOX01A)
-
Target tissue:
urogenital: Testes (TT050A)
-
Effect description:
decreased body weight, feed efficiency,haematological and biochemical changes, changes in weight and histopathological changes of liver, thymus, spleen and adrenal glands, decreased intensity of spermatogenesis in males
-
Effect or parameter linked to the endpoint:
body weight (CHD005BE)
-
Internal remarks:
decreased body weight, heamatological and biochemical changes, organ weight and histopathological findings at dose level 1000 mg/kg/b.w.
Endpoint study
#4: Marx, Tennille K., Reddeman, Robin., Clewell, Amy E., Endres, John R., Beres, Erzsebet., Vertesi, Adel., Glavits, Robert., Hirka, Gabor., Szakonyine, Ilona Pasics. An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp. journal of toxicology, 2018 . DOI: 10.1155/2018/8143582.
[
DOI link]
-
Study relevance:
Human health
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Preparation/Extraction method:
Super-critical gas extraction (A0BZQ)
-
Additional plant/substance description:
CO2
-
Type of toxicological test:
short-term toxicity (CHD017TT)
-
Guideline:
OECD GUIDELINE 407 (REPEATED DOSE 28-DAY ORAL TOXICITY IN RODENTS) (OECD1255PL)
-
Tested organism:
Rat (as animal) (A0CNV)
-
Strain of test organism:
Wistar (CHD013ST)
-
-
Route of exposure:
ORAL: GAVAGE (OECD2231PL)
-
-
Unit of exposure duration:
Day (G134A)
-
Number of organisms dosed:
10
-
Control groups used:
yes, concurrent vehicle
-
Endpoint measured:
Dose level (CHD014EP)
-
Concentration unit:
Milligrams per kilogram body weight (G225A)
-
Effect concentration:
3000
-
Critical effect:
SYSTEMIC (TOX01A)
-
Effect description:
mortality - 3 males and 2 females
-
Effect or parameter linked to the endpoint:
mortality (CHD010BE)
-
Internal remarks:
mortality at dose level 3000/4000 mg/kg/b.w.
Endpoint study
#5: Marx, Tennille K., Reddeman, Robin., Clewell, Amy E., Endres, John R., Beres, Erzsebet., Vertesi, Adel., Glavits, Robert., Hirka, Gabor., Szakonyine, Ilona Pasics. An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp. journal of toxicology, 2018 . DOI: 10.1155/2018/8143582.
[
DOI link]
-
Study relevance:
Human health
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Preparation/Extraction method:
Super-critical gas extraction (A0BZQ)
-
Additional plant/substance description:
CO2
-
Type of toxicological test:
subchronic (CHD013TT)
-
-
Guideline:
OECD GUIDELINE 408 (REPEATED DOSE 90-DAY ORAL TOXICITY IN RODENTS) (OECD1256PL)
-
Tested organism:
Rat (as animal) (A0CNV)
-
Strain of test organism:
Wistar (CHD013ST)
-
-
Route of exposure:
ORAL: GAVAGE (OECD2231PL)
-
-
Unit of exposure duration:
Day (G134A)
-
Number of organisms dosed:
20
-
Control groups used:
yes, concurrent vehicle
-
Endpoint measured:
Dose level (CHD014EP)
-
Concentration unit:
Milligrams per kilogram body weight (G225A)
-
Effect concentration:
360
-
Critical effect:
SYSTEMIC (TOX01A)
-
Target tissue:
Glandular (TT003A)
-
Effect description:
decreased body weight, feed efficiency,haematological and biochemical changes, changes in weight and histopathological changes of adrenal glands
-
Effect or parameter linked to the endpoint:
organ weights (CHD012BE)
-
Internal remarks:
Subchronic toxicity: NOAEL - 100 mg/kg/b.w. for males and 360 mg/kg/b.w. for females
Endpoint study
#6: Chan, PC., Sills, RC., Braun, AG., Haseman, JK., Bucher, JR. Toxicity and carcinogenicity of Delta(9)-tetrahydrocannabinol in Fischer rats and B6C3F1 mice. fundamental and applied toxicology, 1996, vol. 30, no. 1, p. 109–117. DOI: 10.1006/faat.1996.0048.
[
DOI link]
-
Study relevance:
Human health
-
Substance:
delta-9-Tetrahydrocannabinol (RF-00002598-PAR)
-
Plant part:
Unspecified (A07XD)
-
Additional plant/substance description:
pure compound not extracted by the authors
-
Type of toxicological test:
chronic/long term toxicity (CHD004TT)
-
-
Tested organism:
Rat (as animal) (A0CNV)
-
-
Route of exposure:
ORAL: GAVAGE (OECD2231PL)
-
-
Unit of exposure duration:
Week (G205A)
-
Number of organisms dosed:
10
-
Control groups used:
no data
-
Endpoint measured:
Effect concentration 50% organisms show adverse effect (CHD016EP)
-
Concentration unit:
Milligram/kilogram (G061A)
-
Effect concentration:
<=500
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Target tissue:
neurologic: Central Nervous System (TT035A)
-
Effect description:
Aggressive behavior in both dosed male and female rats. Other clinical findings: sensitivity to touch, convulsions, lethargy, diarrhea, and tremors, especially in the 150 and 500 mg/kg groups.
-
Effect or parameter linked to the endpoint:
neurology (CHD027BE)
-
Internal remarks:
Aggressive behavior in both dosed male and female rats. Other clinical findings: sensitivity to touch, convulsions, lethargy, diarrhea, and tremors, especially in the 150 and 500 mg/kg groups.
Endpoint study
#7: Chan, PC., Sills, RC., Braun, AG., Haseman, JK., Bucher, JR. Toxicity and carcinogenicity of Delta(9)-tetrahydrocannabinol in Fischer rats and B6C3F1 mice. fundamental and applied toxicology, 1996, vol. 30, no. 1, p. 109–117. DOI: 10.1006/faat.1996.0048.
[
DOI link]
-
Study relevance:
Human health
-
Substance:
delta-9-Tetrahydrocannabinol (RF-00002598-PAR)
-
Plant part:
Unspecified (A07XD)
-
Additional plant/substance description:
pure compound not extracted by the authors
-
Type of toxicological test:
chronic/long term toxicity (CHD004TT)
-
-
Tested organism:
Rat (as animal) (A0CNV)
-
-
Route of exposure:
ORAL: GAVAGE (OECD2231PL)
-
-
Unit of exposure duration:
Week (G205A)
-
Number of organisms dosed:
10
-
-
Endpoint measured:
Effect concentration 50% organisms show adverse effect (CHD016EP)
-
Concentration unit:
Milligram/kilogram (G061A)
-
Effect concentration:
<=500
-
Critical effect:
REPRODUCTIVE (TOX05A)
-
Target tissue:
Urogenital (TT006A)
-
Effect description:
Uterine atrophy and ovarian hypoplasia with the 150 and 500 mg/kg groups. Ovarian hypoplasia with a decrease in the size of maturing follicles. Estrous cycle lengths of the 15, 50, 150, and 500mg/kg females significantly longer than in controls
-
Effect or parameter linked to the endpoint:
reproduction (CHD014BE)
-
Internal remarks:
Uterine atrophy and ovarian hypoplasia with the 150 and 500 mg/kg groups. Ovarian hypoplasia with a decrease in the size of maturing follicles. Estrous cycle lengths of the 15, 50, 150, and 500mg/kg females significantly longer than in controls