EFSA Compendium of Botanicals

Draft - work in progress

Ylang-ylang (as plant) // Cananga odorata (Lam.) Hook.f. & Thomson

Family:: Annonaceae
Approval state:: Approved
Number of articles retrieved:: 357
Number of processed references:: 12

Compositions

#1: methyl salicylate in essential oil #2: benzyl salicylate in essential oil #3: myrcene in essential oil #4: 1,8-cineole in leaves #5: camphor in leaves #6: eugenol in leaves #7: myristicin in unspecified plant part #8: myrcene in essential oil of fruit #9: Alkaloids in fruit #10: Saponins in fruit #11: Tannins in fruit #12: cleistopholine in seeds #13: anonaine in seeds #14: nornuciferine in seeds #15: N-Acetylnornuciferine in seeds #16: (+)-ushinsunine (isoquinoline alkaloid) in seeds #17: asimilobine in seeds #18: reticuline in seeds #19: (-)-anaxagoreine (aporphine alkaloid) in seeds #20: liriodenine in seeds #21: lyscamine (alkaloid) in fruit #22: cananodine (pyridine alkaloid) in fruit #23: cleistopholine (quinoline alkaloid) in fruit #24: moupinamide in fruit #25: (+)-ushinsunine-beta-N-oxide in fruit #26: eugenol in flower #27: lignan (canalignan II) in bud #28: lignan ester in bud #29: lignan (canalignan I) in bud #30: Liriodenine in bark #31: sampangine (alkaloid) in bark

Endpoint Studies

#1: Reduced sperm count, abnormal sperm morphology and reduced serum testosterone level after dosing with root bark extract #2: central and peripheral analgesic activity #3: Ethanolic bark extract affected male fertility and testosterone level and females did not conceive after mating

Genotoxicity

Composition #1: Ekundayo, Olusegun. A review of the volatiles of the Annonaceae. journal of essential oil research, 1989, vol. 1, no. 5, p. 223–45. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

methyl salicylate (RF-00003930-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.1-1.34
Internal remarks:

methyl salicylate in essential oil

Composition #2: Ekundayo, Olusegun. A review of the volatiles of the Annonaceae. journal of essential oil research, 1989, vol. 1, no. 5, p. 223–45. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Benzyl salicylate (RF-00007911-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.9-5.2
Internal remarks:

benzyl salicylate in essential oil

Composition #3: Ekundayo, Olusegun. A review of the volatiles of the Annonaceae. journal of essential oil research, 1989, vol. 1, no. 5, p. 223–45. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.1-1.0
Internal remarks:

myrcene in essential oil

Composition #4: Cheng, Jun., Yang, Kai., Zhao, Na Na., Wang, Xuan Gao., Wang, Shu Ying., Liu, Zhi Long. Composition and insecticidal activity of the essential oil of Cananga odorata leaves against Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae). journal of medicinal plants research, 2012, vol. 6, no. 18, p. 3482–3486. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

solvent extraction (distilled water), steam distillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

the percent is peak area percent
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.04
Internal remarks:

1,8-cineole in leaves

Composition #5: Cheng, Jun., Yang, Kai., Zhao, Na Na., Wang, Xuan Gao., Wang, Shu Ying., Liu, Zhi Long. Composition and insecticidal activity of the essential oil of Cananga odorata leaves against Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae). journal of medicinal plants research, 2012, vol. 6, no. 18, p. 3482–3486. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

solvent extraction (distilled water), steam distillation
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

the percent is peak area percent
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.23
Internal remarks:

camphor in leaves

Composition #6: Cheng, Jun., Yang, Kai., Zhao, Na Na., Wang, Xuan Gao., Wang, Shu Ying., Liu, Zhi Long. Composition and insecticidal activity of the essential oil of Cananga odorata leaves against Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae). journal of medicinal plants research, 2012, vol. 6, no. 18, p. 3482–3486. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Powder (A06JD)
Additional extraction description:

solvent extraction (distilled water), steam distillation
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

the percent is peak area percent
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

8.86
Internal remarks:

eugenol in leaves

Composition #7: Wang, Lai-Hao., Chen, Jun-Xian., Wang, Chia-Chen. Rapid quantitative analysis of suspected fragrance allergens in between commercial essential oils and using attenuated total reflectance-infrared (ATR-IR) spectroscopy. journal of essential oil research, 2014, vol. 26, no. 3, p. 185–196. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

myristicin (RF-00003941-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

GC-FID
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.033-8.21
Internal remarks:

myristicin in unspecified plant part

Composition #8: Boyom, F. Fekam., Zollo, P. H. Amvam., Menut, C., Lamaty, G., Bessiere, J. M. Aromatic plants of tropical central Africa. Part XXVII. Comparative study of the volatile constituents five Annonaceae species growing in Cameroon . flavour and fragrance journal, 1996, vol. 11, no. 6, p. 333–338. .

Language:

English (en)
Plant part:

Fruit peel (as part-nature) (A067G)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

24.7
Internal remarks:

myrcene in essential oil of fruit

Composition #9: Maniyar, Y.A., Janaki Devi, C.H. Evaluation of analgesic activity of ethanolic extract of cananga odorata lam in experimental animals. international journal of pharma and bio sciences, 2015, vol. 6, no. 2, p. P467–P474. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids in fruit

Composition #10: Maniyar, Y.A., Janaki Devi, C.H. Evaluation of analgesic activity of ethanolic extract of cananga odorata lam in experimental animals. international journal of pharma and bio sciences, 2015, vol. 6, no. 2, p. P467–P474. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins in fruit

Composition #11: Maniyar, Y.A., Janaki Devi, C.H. Evaluation of analgesic activity of ethanolic extract of cananga odorata lam in experimental animals. international journal of pharma and bio sciences, 2015, vol. 6, no. 2, p. P467–P474. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins in fruit

Composition #12: Hsieh, TJ., Chang, FR., Wu, YC. The constituents of Cananga odorata. journal of the chinese chemical society, 1999, vol. 46, no. 4, p. 607–611. . [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

anthraquinones (RF-00004343-PAR)
Additional substance description:

cleistopholine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

and spectroscopic methods
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cleistopholine in seeds

Composition #13: Hsieh, TJ., Chang, FR., Wu, YC. The constituents of Cananga odorata. journal of the chinese chemical society, 1999, vol. 46, no. 4, p. 607–611. . [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

anonaine (RF-00004150-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

and spectroscopic methods
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

anonaine in seeds

Composition #14: Hsieh, TJ., Chang, FR., Wu, YC. The constituents of Cananga odorata. journal of the chinese chemical society, 1999, vol. 46, no. 4, p. 607–611. . [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

nornuciferine (RF-00003519-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

and spectroscopic methods
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

nornuciferine in seeds

Composition #15: Hsieh, TJ., Chang, FR., Wu, YC. The constituents of Cananga odorata. journal of the chinese chemical society, 1999, vol. 46, no. 4, p. 607–611. . [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

N-Acetylnornuciferine (RF-00011444-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

and spectroscopic methods
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

N-Acetylnornuciferine in seeds

Composition #16: Hsieh, TJ., Chang, FR., Wu, YC. The constituents of Cananga odorata. journal of the chinese chemical society, 1999, vol. 46, no. 4, p. 607–611. . [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

(+)-ushinsunine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

and spectroscopic methods
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

(+)-ushinsunine (isoquinoline alkaloid) in seeds

Composition #17: Hsieh, TJ., Chang, FR., Wu, YC. The constituents of Cananga odorata. journal of the chinese chemical society, 1999, vol. 46, no. 4, p. 607–611. . [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

asimilobine (RF-00004160-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

and spectroscopic methods
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

asimilobine in seeds

Composition #18: Hsieh, TJ., Chang, FR., Wu, YC. The constituents of Cananga odorata. journal of the chinese chemical society, 1999, vol. 46, no. 4, p. 607–611. . [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

reticuline (RF-00004026-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

and spectroscopic methods
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

reticuline in seeds

Composition #19: Hsieh, TJ., Chang, FR., Wu, YC. The constituents of Cananga odorata. journal of the chinese chemical society, 1999, vol. 46, no. 4, p. 607–611. . [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

Aporphine alkaloids (RF-00010806-PAR)
Additional substance description:

(-)-anaxagoreine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

and spectroscopic methods
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

(-)-anaxagoreine (aporphine alkaloid) in seeds

Composition #20: Hsieh, TJ., Chang, FR., Wu, YC. The constituents of Cananga odorata. journal of the chinese chemical society, 1999, vol. 46, no. 4, p. 607–611. . [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

liriodenine (RF-00003473-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

and spectroscopic methods
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

liriodenine in seeds

Composition #21: Hsieh, TJ., Chang, FR., Chia, YC., Chen, CY., Chin, HF., Wu, YC. Cytotoxic constituents of the fruits of Cananga odorata. journal of natural products, 2001, vol. 64, no. 5, p. 616–619. DOI: 10.1021/np0005208. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

lyscamine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lyscamine (alkaloid) in fruit

Composition #22: Hsieh, TJ., Chang, FR., Chia, YC., Chen, CY., Chin, HF., Wu, YC. Cytotoxic constituents of the fruits of Cananga odorata. journal of natural products, 2001, vol. 64, no. 5, p. 616–619. DOI: 10.1021/np0005208. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

pyridine alkaloids (RF-00010801-PAR)
Additional substance description:

cananodine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cananodine (pyridine alkaloid) in fruit

Composition #23: Hsieh, TJ., Chang, FR., Chia, YC., Chen, CY., Chin, HF., Wu, YC. Cytotoxic constituents of the fruits of Cananga odorata. journal of natural products, 2001, vol. 64, no. 5, p. 616–619. DOI: 10.1021/np0005208. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

Quinoline alkaloids (RF-00004326-PAR)
Additional substance description:

cleistopholine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cleistopholine (quinoline alkaloid) in fruit

Composition #24: Hsieh, TJ., Chang, FR., Chia, YC., Chen, CY., Chin, HF., Wu, YC. Cytotoxic constituents of the fruits of Cananga odorata. journal of natural products, 2001, vol. 64, no. 5, p. 616–619. DOI: 10.1021/np0005208. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

Moupinamide (RF-00011093-PAR)
Additional substance description:

syn. of N-trans-feruloyltyramine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

moupinamide in fruit

Composition #25: Hsieh, TJ., Chang, FR., Chia, YC., Chen, CY., Chin, HF., Wu, YC. Cytotoxic constituents of the fruits of Cananga odorata. journal of natural products, 2001, vol. 64, no. 5, p. 616–619. DOI: 10.1021/np0005208. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

Aporphine alkaloids (RF-00010806-PAR)
Additional substance description:

(+)-ushinsunine-beta-N-oxide
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

(+)-ushinsunine-beta-N-oxide in fruit

Composition #26: Muchjajib, U., Muchjajib, S., Mathe, A., Barata, AM., Carlen, C., Craker, L. Effect of Picking Time on Essential Oil Yield of Ylang-Ylang (Cananga odorata) . xxviii international horticultural congress on science and horticulture for people (ihc2010): a new look at medicinal and aromatic plants seminar, 2011, vol. 925, p. 243–248. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydro-distillation, isolation using Clevenger type apparatus
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.65
Internal remarks:

eugenol in flower

Composition #27: Matsumoto, Takahiro., Nakamura, Seikou., Nakashima, Souichi., Fujimoto, Katsuyoshi., Yoshikawa, Masayuki., Ohta, Tomoe., Ogawa, Keiko., Matsuda, Hisashi. Lignan Dicarboxylates and Terpenoids from the Flower Buds of Cananga odorata and Their Inhibitory Effects on Melanogenesis . journal of natural products, 2014, vol. 77, no. 4, p. 990–999. DOI: 10.1021/np401091f. [DOI link]

Language:

English (en)
Plant part:

Bud (as part-nature) (A066Z)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

canalignan II
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0015
Internal remarks:

lignan (canalignan II) in bud

Composition #28: Matsumoto, Takahiro., Nakamura, Seikou., Nakashima, Souichi., Fujimoto, Katsuyoshi., Yoshikawa, Masayuki., Ohta, Tomoe., Ogawa, Keiko., Matsuda, Hisashi. Lignan Dicarboxylates and Terpenoids from the Flower Buds of Cananga odorata and Their Inhibitory Effects on Melanogenesis . journal of natural products, 2014, vol. 77, no. 4, p. 990–999. DOI: 10.1021/np401091f. [DOI link]

Language:

English (en)
Plant part:

Bud (as part-nature) (A066Z)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

lignan ester
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0038
Internal remarks:

lignan ester in bud

Composition #29: Matsumoto, Takahiro., Nakamura, Seikou., Nakashima, Souichi., Fujimoto, Katsuyoshi., Yoshikawa, Masayuki., Ohta, Tomoe., Ogawa, Keiko., Matsuda, Hisashi. Lignan Dicarboxylates and Terpenoids from the Flower Buds of Cananga odorata and Their Inhibitory Effects on Melanogenesis . journal of natural products, 2014, vol. 77, no. 4, p. 990–999. DOI: 10.1021/np401091f. [DOI link]

Language:

English (en)
Plant part:

Bud (as part-nature) (A066Z)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

canalignan I
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.052
Internal remarks:

lignan (canalignan I) in bud

Composition #30: RAO, JUM., GIRI, GS., HANUMAIAH, T., RAO, KVJ. SAMPANGINE, A NEW ALKALOID FROM CANANGA-ODORATA. journal of natural products, 1986, vol. 49, no. 2, p. 346–347. DOI: 10.1021/np50044a029. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane, chloroform
Substance:

liriodenine (RF-00003473-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Liriodenine in bark

Composition #31: RAO, JUM., GIRI, GS., HANUMAIAH, T., RAO, KVJ. SAMPANGINE, A NEW ALKALOID FROM CANANGA-ODORATA. journal of natural products, 1986, vol. 49, no. 2, p. 346–347. DOI: 10.1021/np50044a029. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane, chloroform
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

sampangine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

sampangine (alkaloid) in bark

Endpoint study #1: Anitha, P., Indira, M. Impact of feeding ethanolic extract of root bark of Cananga odorata (Lam) on reproductive functions in male rats . indian journal of experimental biology, 2006, vol. 44, no. 12, p. 976–980. .

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Sprague-Dawley (CHD012ST)
Sex:

Male
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration:

60.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

36
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight per day (G211A)
Effect concentration:

500
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Testes (TT050A)
Effect description:

500 mg/kg b.w. per day: reduced sperm motility and increased abnormal sperm. At 1000 mg/kg b.w. per day: reduced sperm count, abnormal sperm, reduced serum testosterone
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

Reduced sperm count, abnormal sperm morphology and reduced serum testosterone level after dosing with root bark extract

Endpoint study #2: Maniyar, Y.A., Janaki Devi, C.H. Evaluation of analgesic activity of ethanolic extract of cananga odorata lam in experimental animals. international journal of pharma and bio sciences, 2015, vol. 6, no. 2, p. P467–P474. .

Study relevance:

Human health
Plant part:

Fruit unspecified (as part-nature) (A067D)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

Ethanol
Type of toxicological test:

not reported (CHD015TT)
Tested organism:

Rat (as animal) (A0CNV)
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Number of organisms dosed:

30
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

100-400
Target tissue:

Neurologic (TT004A)
Effect description:

central and peripheral analgesic activity
Effect or parameter linked to the endpoint:

neurology (CHD027BE)
Internal remarks:

central and peripheral analgesic activity

Endpoint study #3: Pankajakshy, Anitha., Madambath, Indira. Spermatotoxic effects of Cananga odorata (Lam): a comparison with gossypol . fertility and sterility, 2009, vol. 91, no. 5, p. 2243–2246. DOI: 10.1016/j.fertnstert.2008.05.075. [DOI link]

Study relevance:

Human health
Plant part:

Bark (as part-nature) (A066X)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

oral route
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Sprague-Dawley (CHD012ST)
Sex:

Male
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Number of organisms dosed:

18
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Grams per kilogram body weight per day (G212A)
Effect concentration:

1
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Testes (TT050A)
Effect description:

Abnormal sperms, reduced sperm count and motility, reduced serum testosterone level and female rats did not conceive after mating
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

Ethanolic bark extract affected male fertility and testosterone level and females did not conceive after mating