Draft - work in progress
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- Tea (as plant) // Camellia sinensis (L.) Kuntze // Thea sinensis L.
Tea (as plant) // Camellia sinensis (L.) Kuntze // Thea sinensis L.
- Family:
- Theaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 20274
- Number of processed references:
- 6
Composition #1: No Author and Editor data available. NTP Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies). national toxicology program technical report series, 1998, vol. 473, p. 1–326. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Additional extraction description:
unspecified
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Substance:
theophylline (RF-00004078-PAR)
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Analytical method code:
Unspecified (F598A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Theophylline in leaves
Composition #2: Nikaidou, S., Ishizuka, M., Maeda, Y., Hara, Y., Kazusaka, A., Fujita, S. Effect of components of green tea extracts, caffeine and catechins on hepatic drug metabolizing enzyme activities and mutagenic transformation of carcinogens . japanese journal of veterinary research, 2005, vol. 52, no. 4, p. 185–192. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
water
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Substance:
epigallocatechin gallate (RF-00003802-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
10.9
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Internal remarks:
Epigallocatechin gallate in leaves
Composition #3: Nikaidou, S., Ishizuka, M., Maeda, Y., Hara, Y., Kazusaka, A., Fujita, S. Effect of components of green tea extracts, caffeine and catechins on hepatic drug metabolizing enzyme activities and mutagenic transformation of carcinogens . japanese journal of veterinary research, 2005, vol. 52, no. 4, p. 185–192. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
water
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Substance:
Epicatechin-3-gallate (RF-00010397-PAR)
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Additional substance description:
Epicatechin gallate
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
2.8
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Internal remarks:
Epicatechin gallate in leaves
Composition #4: Nikaidou, S., Ishizuka, M., Maeda, Y., Hara, Y., Kazusaka, A., Fujita, S. Effect of components of green tea extracts, caffeine and catechins on hepatic drug metabolizing enzyme activities and mutagenic transformation of carcinogens . japanese journal of veterinary research, 2005, vol. 52, no. 4, p. 185–192. .
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-
Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
water
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Substance:
caffeine (RF-00000038-NTR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
6.9
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Internal remarks:
Caffeine in leaves
Composition #5: Nikaidou, S., Ishizuka, M., Maeda, Y., Hara, Y., Kazusaka, A., Fujita, S. Effect of components of green tea extracts, caffeine and catechins on hepatic drug metabolizing enzyme activities and mutagenic transformation of carcinogens . japanese journal of veterinary research, 2005, vol. 52, no. 4, p. 185–192. .
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-
Plant part:
Leaves (as part-nature) (A0EKT)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
water
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Substance:
Epigallocatechin (RF-00010399-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
10.4
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Internal remarks:
Epigallocatechin in leaves
Composition #6: Isbrucker, RA., Bausch, J., Edwards, JA., Wolz, E. Safety studies on epigallocatechin gallate (EGCG) preparations. Part 1: Genotoxicity . food and chemical toxicology, 2006, vol. 44, no. 5, p. 626–635. DOI: 10.1016/j.fct.2005.07.005.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
hot water
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Substance:
caffeine (RF-00000038-NTR)
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Analytical method code:
Chromatographic tests (F015A)
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Analytical method - additional description:
chromatographic separation of EGCG from the catechin fraction in ethanol/water followed by crystallization or spray drying
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
<=0.13
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Internal remarks:
Caffeine in leaves
Composition #7: Isbrucker, RA., Bausch, J., Edwards, JA., Wolz, E. Safety studies on epigallocatechin gallate (EGCG) preparations. Part 1: Genotoxicity . food and chemical toxicology, 2006, vol. 44, no. 5, p. 626–635. DOI: 10.1016/j.fct.2005.07.005.
[
DOI link]
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-
Plant part:
Leaves (as part-nature) (A0EKT)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
hot water
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Substance:
Epicatechin-3-gallate (RF-00010397-PAR)
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Analytical method code:
Chromatographic tests (F015A)
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Analytical method - additional description:
chromatographic separation of EGCG from the catechin fraction in ethanol/water followed by crystallization or spray drying
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
<=0.91
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Internal remarks:
Epicatechin gallate in leaves
Composition #8: Isbrucker, RA., Bausch, J., Edwards, JA., Wolz, E. Safety studies on epigallocatechin gallate (EGCG) preparations. Part 1: Genotoxicity . food and chemical toxicology, 2006, vol. 44, no. 5, p. 626–635. DOI: 10.1016/j.fct.2005.07.005.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
hot water
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Substance:
Gallocatechin-3-gallate (RF-00010396-PAR)
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Additional substance description:
gallocatechin gallate
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Analytical method code:
Chromatographic tests (F015A)
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Analytical method - additional description:
chromatographic separation of EGCG from the catechin fraction in ethanol/water followed by crystallization or spray drying
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
<=1.6
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Internal remarks:
Gallocatechin gallate in leaves
Composition #9: Li, Bo., Jin, Yuxia., Xu, Yi., Wu, Yuanyuan., Xu, Jiying., Tu, Youying. Safety evaluation of tea (Camellia sinensis (L.) O. Kuntze) flower extract: Assessment of mutagenicity, and acute and subchronic toxicity in rats . journal of ethnopharmacology, 2011, vol. 133, no. 2, p. 583–590. DOI: 10.1016/j.jep.2010.02.030.
[
DOI link]
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Plant part:
Flower (as part-nature) (A067B)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
water
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Substance:
Saponins (RF-00004333-PAR)
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Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.9
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Internal remarks:
Saponins in flowers
Composition #10: Li, Bo., Jin, Yuxia., Xu, Yi., Wu, Yuanyuan., Xu, Jiying., Tu, Youying. Safety evaluation of tea (Camellia sinensis (L.) O. Kuntze) flower extract: Assessment of mutagenicity, and acute and subchronic toxicity in rats . journal of ethnopharmacology, 2011, vol. 133, no. 2, p. 583–590. DOI: 10.1016/j.jep.2010.02.030.
[
DOI link]
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Plant part:
Flower (as part-nature) (A067B)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
water
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Substance:
caffeine (RF-00000038-NTR)
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Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
3.1
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Internal remarks:
Caffeine in flowers
Composition #11: BuAbbas, A., Copeland, E., Clifford, MN., Walker, R., Ioannides, C. Fractionation of green tea extracts: Correlation of antimutagenic effect with flavanol content . journal of the science of food and agriculture, 1997, vol. 75, no. 4, p. 453–462. DOI: 10.1002/(SICI)1097-0010(199712)75:4<453::AID-JSFA897>3.0.CO;2-3.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
water
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Substance:
Epigallocatechin (RF-00010399-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Epigallocatechin in leaves
Composition #12: BuAbbas, A., Copeland, E., Clifford, MN., Walker, R., Ioannides, C. Fractionation of green tea extracts: Correlation of antimutagenic effect with flavanol content . journal of the science of food and agriculture, 1997, vol. 75, no. 4, p. 453–462. DOI: 10.1002/(SICI)1097-0010(199712)75:4<453::AID-JSFA897>3.0.CO;2-3.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
water
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Substance:
gallic acid (RF-00003821-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Gallic acid in leaves
Composition #13: BuAbbas, A., Copeland, E., Clifford, MN., Walker, R., Ioannides, C. Fractionation of green tea extracts: Correlation of antimutagenic effect with flavanol content . journal of the science of food and agriculture, 1997, vol. 75, no. 4, p. 453–462. DOI: 10.1002/(SICI)1097-0010(199712)75:4<453::AID-JSFA897>3.0.CO;2-3.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
water
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Substance:
epigallocatechin gallate (RF-00003802-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Epigallocatechin gallate in leaves
Endpoint study
#1: Wu, Kuei-Meng., Yao, Jiaqin., Boring, Daniel. Green Tea Extract-Induced Lethal Toxicity in Fasted but Not in Nonfasted Dogs . international journal of toxicology, 2011, vol. 30, no. 1, p. 19–20. DOI: 10.1177/1091581810387445.
[
DOI link]
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Study relevance:
Animal (target species) health
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Plant part:
Leaves (as part-nature) (A0EKT)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
water
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Type of toxicological test:
short-term toxicity (CHD017TT)
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Tested organism:
Dog (as animal) (A0CNL)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Unit of exposure duration:
Week (G205A)
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Endpoint measured:
Lowest lethal dose (CHD025EP)
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Concentration unit:
Milligrams per kilogram body weight per day (G211A)
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Effect concentration:
150-500
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Critical effect:
SYSTEMIC (TOX01A)
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Effect description:
Green Tea Extract-Induced Lethal Toxicity in Fasted dogs
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Effect or parameter linked to the endpoint:
mortality (CHD010BE)
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Internal remarks:
Lethality in dogs