EFSA Compendium of Botanicals

Draft - work in progress

Camellia sasanqua Thunb.

Family:: Theaceae
Approval state:: Approved
Number of articles retrieved:: 316
Number of processed references:: 2

Compositions

Endpoint Studies

#1: mortality, Hypoactivity, low temperature, polierection, cyanosis #2: diarrhoea, hypoactivity,polierection, low temperature and cyanosis LD50 #3: mortality, GI distension, fluid accumulation #4: diarrhoea, hypoactivity LOAEL

Genotoxicity

Composition #1: Matsuda, Hisashi., Nakamura, Seikou., Fujimoto, Katsuyoshi., Moriuchi, Ryo., Kimura, Yuta., Ikoma, Noriko., Hata, Yuki., Muraoka, Osamu., Yoshikawa, Masayuki. Medicinal Flowers. XXXI. Acylated Oleanane-Type Triterpene Saponins, Sasanquasaponins I-V, with Antiallergic Activity from the Flower Buds of Camellia sasanqua . chemical & pharmaceutical bulletin, 2010, vol. 58, no. 12, p. 1617–1621. DOI: 10.1248/cpb.58.1617. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

sasanquasaponins I-V
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

column chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins in flowers NMR

Endpoint study #1: Shen, Jia., Cao, Cunai., Su, Hui., Yang, Xiuwei., Wei, Zuohan., Du, Lijun. Evidence of gastro-intestinal system as an active and toxic target of sasanqua saponins extract . experimental and toxicologic pathology, 2008, vol. 60, no. 1, p. 43–49. DOI: 10.1016/j.etp.2007.11.016. [DOI link]

Study relevance:

Human health
Substance:

Saponins (RF-00004333-PAR)
Plant part:

Seed (as part-nature) (A066P)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

ICR (CHD044ST)
Sex:

Male/Female
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration:

2.0
Unit of exposure duration:

Week (G205A)
Number of organisms dosed:

10
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

2000
Critical effect:

NOT REPORTED (TOX17A)
Target tissue:

Digestive (TT002A)
Effect description:

death,diarrhoea hypoactivity, low temperature, polierection, cyanosis
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

mortality, Hypoactivity, low temperature, polierection, cyanosis

Endpoint study #2: Shen, Jia., Cao, Cunai., Su, Hui., Yang, Xiuwei., Wei, Zuohan., Du, Lijun. Evidence of gastro-intestinal system as an active and toxic target of sasanqua saponins extract . experimental and toxicologic pathology, 2008, vol. 60, no. 1, p. 43–49. DOI: 10.1016/j.etp.2007.11.016. [DOI link]

Study relevance:

Human health
Substance:

Saponins (RF-00004333-PAR)
Plant part:

Seed (as part-nature) (A066P)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

ICR (CHD044ST)
Sex:

Male/Female
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration:

2.0
Unit of exposure duration:

Week (G205A)
Number of organisms dosed:

10
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Dose producing lethality in 50% of experimental organisms (CHD024EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

1143.7
Critical effect:

NOT REPORTED (TOX17A)
Target tissue:

Digestive (TT002A)
Effect description:

death, diarrhoea, hypoactivity, polierection, low temperature, cyanosis
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

diarrhoea, hypoactivity,polierection, low temperature and cyanosis LD50

Endpoint study #3: Shen, Jia., Cao, Cunai., Su, Hui., Yang, Xiuwei., Wei, Zuohan., Du, Lijun. Evidence of gastro-intestinal system as an active and toxic target of sasanqua saponins extract . experimental and toxicologic pathology, 2008, vol. 60, no. 1, p. 43–49. DOI: 10.1016/j.etp.2007.11.016. [DOI link]

Study relevance:

Human health
Substance:

Saponins (RF-00004333-PAR)
Plant part:

Seed (as part-nature) (A066P)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Type of toxicological test:

subchronic (CHD013TT)
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

ICR (CHD044ST)
Sex:

Male/Female
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration:

3.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

10
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

400
Critical effect:

NOT REPORTED (TOX17A)
Target tissue:

Digestive (TT002A)
Effect description:

death, GI distension, fluid accumulation
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

mortality, GI distension, fluid accumulation

Endpoint study #4: Shen, Jia., Cao, Cunai., Su, Hui., Yang, Xiuwei., Wei, Zuohan., Du, Lijun. Evidence of gastro-intestinal system as an active and toxic target of sasanqua saponins extract . experimental and toxicologic pathology, 2008, vol. 60, no. 1, p. 43–49. DOI: 10.1016/j.etp.2007.11.016. [DOI link]

Study relevance:

Human health
Substance:

Saponins (RF-00004333-PAR)
Plant part:

Seed (as part-nature) (A066P)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

ICR (CHD044ST)
Sex:

Male/Female
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration:

2.0
Unit of exposure duration:

Week (G205A)
Number of organisms dosed:

10
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Lowest observed adverse effect level (CHD026EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

250
Critical effect:

NOT REPORTED (TOX17A)
Target tissue:

Digestive (TT002A)
Effect description:

diarrhoea, hypoactivity
Effect or parameter linked to the endpoint:

other (CHD003BE)
Internal remarks:

diarrhoea, hypoactivity LOAEL