EFSA Compendium of Botanicals
Draft
- work in progress
Brachyglottis repanda J.R.Forst. & G.Forst
Brachyglottis repanda J.R.Forst. & G.Forst
Family:
Asteraceae
Approval state:
Approved
Number of articles retrieved:
18
Number of processed references:
2
Compositions
#1: Senecionine in aerial parts
#2: Senkirkine in aerial parts
Endpoint Studies
#1: hepatotoxicity in guinea-pigs
Genotoxicity
Composition #1
: Benn, Michael., Gul, Waseem. Pyrrolizidine alkaloids in the antipodean genus Brachyglottis (Asteraceae) . biochemical systematics and ecology, 2007, vol. 35, no. 10, p. 676–681. DOI: 10.1016/j.bse.2007.05.003. [
DOI link
]
Language:
English (en)
Plant part:
Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:
Solvent extraction (A0BZR)
Additional extraction description:
EtOH
Substance:
Senecionine (RF-00000232-TOX)
Analytical method code:
GC-MS (F046A)
Yes/No Qualitative:
Positive/Present (POS)
Result type:
Qualitative Value (Binary) (BIN)
Internal remarks:
Senecionine in aerial parts
Composition #2
: Benn, Michael., Gul, Waseem. Pyrrolizidine alkaloids in the antipodean genus Brachyglottis (Asteraceae) . biochemical systematics and ecology, 2007, vol. 35, no. 10, p. 676–681. DOI: 10.1016/j.bse.2007.05.003. [
DOI link
]
Language:
English (en)
Plant part:
Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:
Solvent extraction (A0BZR)
Additional extraction description:
EtOH
Substance:
Senkirkine (RF-00000300-TOX)
Analytical method code:
GC-MS (F046A)
Yes/No Qualitative:
Positive/Present (POS)
Result type:
Qualitative Value (Binary) (BIN)
Internal remarks:
Senkirkine in aerial parts
Endpoint study #1
: MORTIMER, PH., WHITE, EP. HEPATOTOXIC SUBSTANCE IN BRACHYGLOTTIS REPANDA. nature, 1967, vol. 214, no. 5094, p. 1255–&. DOI: 10.1038/2141255a0. [
DOI link
]
Study relevance:
Human health
Plant part:
Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:
Solvent extraction (A0BZR)
Additional plant/substance description:
organic solvent
Type of toxicological test:
short-term toxicity (CHD017TT)
Limit test:
Not applicable
Tested organism:
Guinea pig (as animal) (A0CTN)
Sex:
No data
Exposure duration:
28.0
Unit of exposure duration:
Day (G134A)
Number of organisms dosed:
73
Endpoint measured:
Dose level (CHD014EP)
Concentration unit:
Gram (G148A)
Effect concentration:
10-12
Critical effect:
HEPATOTOXICITY (TOX02A)
Target tissue:
digestive: Liver (TT023A)
Effect description:
necrosis, inflammatory exudate, fibroblastic activity, phlebitis and thrombotic lesions, biochemical changes
Effect or parameter linked to the endpoint:
histopathology non neoplastic (CHD025BE)
Internal remarks:
hepatotoxicity in guinea-pigs
