EFSA
ecomole
vscht
  2. Paw paw (as plant) // Asimina triloba (L.) Dunal

Paw paw (as plant) // Asimina triloba (L.) Dunal

Family:
Annonaceae
Approval state:
Approved
Number of articles retrieved:
563
Number of processed references:
12
Compositions
#1: annonacin - fruit #2: squamocin - fruit #3: asimin - seed #4: Asitrilobin A, B - seed #5: asiminacin - seed #6: annonacin - seed #7: asitrilobin C, D - seed #8: cis-, trans-asitrocinone, asitronin - seed #9: Annonaicin from fruit pulp #10: syringaresinol - bark #11: trilobacin, asimicin, bullatacin, bullatacinone, N-pcoumaroyltyramine, N-trans-feruloyltyramine - bark #12: bullatin-2 and bullanin-5 #13: 16,19-cis-murisolin, murisolin A, murisolin - seed #14: asitribin, asiminenins A, B - seed #15: cis-, trans-murisolinone - seed #16: asimilobine - seed #17: asiminocin - stem bark #18: trilobacin, 2,4-cis- and 2,4-trans-trilobacinone - stem bark
Endpoint Studies
Genotoxicity
Composition #1: Levine Robert A., Richards Kristy M., Tran Kevin., Luo Rensheng., Thomas Andrew L., Smith Robert E. Determination of Neurotoxic Acetogenins in Pawpaw (Asimina triloba) Fruit by LC-HRMS. journal of agricultural and food chemistry, 2015, p. Journal of agricultural and food chemistry (2015). .
Composition #2: Levine Robert A., Richards Kristy M., Tran Kevin., Luo Rensheng., Thomas Andrew L., Smith Robert E. Determination of Neurotoxic Acetogenins in Pawpaw (Asimina triloba) Fruit by LC-HRMS. journal of agricultural and food chemistry, 2015, p. Journal of agricultural and food chemistry (2015). .
Composition #3: Woo, MH., Kim, DH., McLaughlin, JL. Asitrilobins A and B: cytotoxic mono-THF Annonaceous acetogenins from the seeds of Asimina triloba . phytochemistry, 1999, vol. 50, no. 6, p. 1033–1040. DOI: 10.1016/S0031-9422(98)00632-3. [DOI link]
Composition #4: Woo, MH., Kim, DH., McLaughlin, JL. Asitrilobins A and B: cytotoxic mono-THF Annonaceous acetogenins from the seeds of Asimina triloba . phytochemistry, 1999, vol. 50, no. 6, p. 1033–1040. DOI: 10.1016/S0031-9422(98)00632-3. [DOI link]
Composition #5: Woo, MH., Kim, DH., McLaughlin, JL. Asitrilobins A and B: cytotoxic mono-THF Annonaceous acetogenins from the seeds of Asimina triloba . phytochemistry, 1999, vol. 50, no. 6, p. 1033–1040. DOI: 10.1016/S0031-9422(98)00632-3. [DOI link]
Composition #6: Woo, MH., Kim, DH., McLaughlin, JL. Asitrilobins A and B: cytotoxic mono-THF Annonaceous acetogenins from the seeds of Asimina triloba . phytochemistry, 1999, vol. 50, no. 6, p. 1033–1040. DOI: 10.1016/S0031-9422(98)00632-3. [DOI link]
Composition #7: Woo, MH., Chung, SO., Kim, DH. Asitrilobins C and D: Two new cytotoxic mono-tetrahydrofuran annonaceous acetogenins from Asimina triloba seeds . bioorganic & medicinal chemistry, 2000, vol. 8, no. 1, p. 285–290. DOI: 10.1016/S0968-0896(99)00277-1. [DOI link]
Composition #8: Kim, EJ., Tian, F., Woo, MH. Asitrocin, (2,4)-cis- and trans-asitrocinones: Novel bioactive mono-tetrahydrofuran acetogenins from Asimina triloba seeds . journal of natural products, 2000, vol. 63, no. 11, p. 1503–1506. DOI: 10.1021/np000180q. [DOI link]
Composition #9: Potts, Lisa F., Luzzio, Frederick A., Smith, Scott C., Hetman, Michal., Champy, Pierre., Litvan, Irene. Annonacin in Asimina triloba fruit: Implication for neurotoxicity. neurotoxicology, 2012, vol. 33, no. 1, p. 53–58. DOI: 10.1016/j.neuro.2011.10.009. [DOI link]
Composition #10: ZHAO, GX., HUI, YH., RUPPRECHT, JK., MCLAUGHLIN, JL., WOOD, KV. ADDITIONAL BIOACTIVE COMPOUNDS AND TRILOBACIN, A NOVEL HIGHLY CYTOTOXIC ACETOGENIN, FROM THE BARK OF ASIMINA-TRILOBA . journal of natural products, 1992, vol. 55, no. 3, p. 347–356. DOI: 10.1021/np50081a011. [DOI link]
Composition #11: ZHAO, GX., HUI, YH., RUPPRECHT, JK., MCLAUGHLIN, JL., WOOD, KV. ADDITIONAL BIOACTIVE COMPOUNDS AND TRILOBACIN, A NOVEL HIGHLY CYTOTOXIC ACETOGENIN, FROM THE BARK OF ASIMINA-TRILOBA . journal of natural products, 1992, vol. 55, no. 3, p. 347–356. DOI: 10.1021/np50081a011. [DOI link]
Composition #12: ZHAO, GX., NG, JH., KOZLOWZKI, JF., SMITH, DL., MCLAUGHLIN, JL. BULLATIN AND BULLANIN - 2 NOVEL, HIGHLY CYTOTOXIC ACETOGENINS FROM ASIMINA-TRILOBA . heterocycles, 1994, vol. 38, no. 8, p. 1897–1908. .
Composition #13: WOO, MH., ZENG, L., YE, Q., GU, ZM., ZHAO, GX., MCLAUGHLIN, JL. 16,19-CIS-MURISOLIN AND MURISOLIN-A, 2 NOVEL BIOACTIVE MONO-TETRAHYDROFURAN ANNONACEOUS ACETOGENINS FROM ASIMINA-TRILOBA SEEDS . bioorganic & medicinal chemistry letters, 1995, vol. 5, no. 11, p. 1135–1140. DOI: 10.1016/0960-894X(95)00182-S. [DOI link]
Composition #14: WOO, MH., ZENG, L., MCLAUGHLIN, JL. ASITRIBIN AND ASIMINENIN-A AND ASIMINENIN-B, NOVEL BIOACTIVE ANNONACEOUS ACETOGENINS FROM THE SEEDS OF ASIMINA-TRILOBA . heterocycles, 1995, vol. 41, no. 8, p. 1731–1742. .
Composition #15: Woo, MH., Cho, KY., Zhang, Y., Zeng, L., Gu, ZM., McLaughlin, JL. Asimilobin and cis- and trans-murisolinones, novel bioactive annonaceous acetogenins from the seeds of Asimina triloba . journal of natural products, 1995, vol. 58, no. 10, p. 1533–1542. DOI: 10.1021/np50124a009. [DOI link]
Composition #16: Woo, MH., Cho, KY., Zhang, Y., Zeng, L., Gu, ZM., McLaughlin, JL. Asimilobin and cis- and trans-murisolinones, novel bioactive annonaceous acetogenins from the seeds of Asimina triloba . journal of natural products, 1995, vol. 58, no. 10, p. 1533–1542. DOI: 10.1021/np50124a009. [DOI link]
Composition #17: Zhao, GX., Chao, JF., Zeng, L., Rieser, MJ., McLaughlin, JL. The absolute configuration of adjacent bis-THF acetogenins and asiminocin, a novel highly potent asimicin isomer from Asimina triloba . bioorganic & medicinal chemistry, 1996, vol. 4, no. 1, p. 25–32. DOI: 10.1016/0968-0896(95)00155-7. [DOI link]
Composition #18: He, K., Zhao, GX., Shi, G., Zeng, L., Chao, JF., McLaughlin, JL. Additional bioactive annonaceous acetogenins from Asimina triloba (Annonaceae) . bioorganic & medicinal chemistry, 1997, vol. 5, no. 3, p. 501–506. DOI: 10.1016/S0968-0896(96)00264-7. [DOI link]