EFSA Compendium of Botanicals

Draft - work in progress

Asclepias syriaca L.

Family:: Apocynaceae (Asclepiadaceae)
Approval state:: Approved
Number of articles retrieved:: 1163
Number of processed references:: 3

Compositions

#1: Nicotine (in roots and leaves) #2: Pyridine alkaloids (in roots and leaves) #3: p-coumaric acid - flower #4: p-coumaric acid - leaves #5: gallic acid- flower #6: Neolignan: 9′-O-Butyl-3-O-demethyl-9-O-β-D-glucopyranosyldehydrodiconiferyl alcohol #7: Cardiac glycosides: 3-O-β-Dglucopyranosyl-(1→4)-6-deoxy-β-D-allopyranosyluzarigenin, uzarin, and desglucouzarin.

Endpoint Studies

Genotoxicity

Composition #1: Kowalewski, Zdzislaw., Drost, Krystyna. Chromatographic research of alkaloids in the roots and leaves of Asclepias syriaca. prace komisji farmaceutycznej, poznanskie towarzystwo przyjaciol nauk, 1966, vol. 5, p. 75–83. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Column Chromatography
Substance:

Nicotine (RF-0809-001-PPP)
Additional substance description:

Pyridine alkaloids
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Nicotine (in roots and leaves)

Composition #2: Kowalewski, Zdzislaw., Drost, Krystyna. Chromatographic research of alkaloids in the roots and leaves of Asclepias syriaca. prace komisji farmaceutycznej, poznanskie towarzystwo przyjaciol nauk, 1966, vol. 5, p. 75–83. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Column Chromatography
Substance:

pyridine alkaloids (RF-00010801-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pyridine alkaloids (in roots and leaves)

Composition #3: Sikorska, M., Matlawska, I., Glowniak, K., Zgorka, G. Qualitative and quantitative analysis of phenolic acids in Asclepias syriaca L. . acta poloniae pharmaceutica, 2000, vol. 57, no. 1, p. 69–72. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

extrated with boiling ethanol 95%
Substance:

p-coumaric acid (RF-00010717-PAR)
Additional substance description:

trans-coumaric
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

TLC, HPLC
Result unit:

Microgram/gram (G049A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.89-5.56
Internal remarks:

p-coumaric acid - flower

Composition #4: Sikorska, M., Matlawska, I., Glowniak, K., Zgorka, G. Qualitative and quantitative analysis of phenolic acids in Asclepias syriaca L. . acta poloniae pharmaceutica, 2000, vol. 57, no. 1, p. 69–72. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

extrated with boiling ethanol 95%
Substance:

p-coumaric acid (RF-00010717-PAR)
Additional substance description:

trans-coumaric
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

TLC, HPLC
Result unit:

Microgram/gram (G049A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.7-17.8
Internal remarks:

p-coumaric acid - leaves

Composition #5: Sikorska, M., Matlawska, I., Glowniak, K., Zgorka, G. Qualitative and quantitative analysis of phenolic acids in Asclepias syriaca L. . acta poloniae pharmaceutica, 2000, vol. 57, no. 1, p. 69–72. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

extrated with boiling ethanol 95%
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

TLC, HPLC
Result unit:

Microgram/gram (G049A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.05
Internal remarks:

gallic acid- flower

Composition #6: Araya, Juan J., Kindscher, Kelly., Timmermann, Barbara N. Cytotoxic Cardiac Glycosides and Other Compounds from Asclepias Syriaca. journal of natural products, 2012, vol. 75, no. 3, p. 400–407. DOI: 10.1021/np2008076. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH/dichloromethane, column chromatography
Substance:

neolignans (RF-00004386-PAR)
Additional substance description:

9′-O-Butyl-3-O-demethyl-9-O-β-D-glucopyranosyldehydrodiconiferyl alcohol
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR, UV, MA, HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Neolignan: 9′-O-Butyl-3-O-demethyl-9-O-β-D-glucopyranosyldehydrodiconiferyl alcohol

Composition #7: Araya, Juan J., Kindscher, Kelly., Timmermann, Barbara N. Cytotoxic Cardiac Glycosides and Other Compounds from Asclepias Syriaca. journal of natural products, 2012, vol. 75, no. 3, p. 400–407. DOI: 10.1021/np2008076. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH/dichloromethane: column chromatograpphy
Substance:

cardenolides (RF-00004389-PAR)
Additional substance description:

3-O-β-Dglucopyranosyl-(1→4)-6-deoxy-β-D-allopyranosyluzarigenin, uzarin, and desglucouzarin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR, UV, MA, HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cardiac glycosides: 3-O-β-Dglucopyranosyl-(1→4)-6-deoxy-β-D-allopyranosyluzarigenin, uzarin, and desglucouzarin.