EFSA Compendium of Botanicals

Draft - work in progress

Artemisia maritima L. // Seriphidium maritimum (L.) Poljakov.

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 263
Number of processed references:: 8

Compositions

#1: Santonin in flower buds #2: Camphor, hydroxylamine, semicarbazide in aerial parts #3: Alkaloids were detected in Artemisia maritima #4: A saponin was detected,but not characterized in Artemisia maritima #5: Santonin was dose in buds (0.71%) #6: Santonin was dosed in leaves (1.81%) #7: 1,8-cineole in aerial parts #8: Alpha -thujone in aerial parts #9: Beta-myrcene variable levels (0.0-1.21 %) have been detected in the essential oil of te aerial part of Artemisia maritima #10: 1,8-cineole variable levels (23.8-44.2%) have been detected in the essential oil of the aerial part of Artemisia maritima #11: Camphor variable levels (0.0-9.2 %) have been detected in the essential oil of the aerial part of Artemisia maritima #12: The essential oil of Artemisia maritima L. contains variable amounts of alpha-tujone (63-2-72.1 %) #13: The essential oil of Artemisia maritima L. contains variable amounts of beta-tujone (8.4 %) #14: The essential oil of Artemisia maritima L. contains variable amounts of 1,8-cineole (1.6-44.2 %) #15: The essential oil of Artemisia maritima L. contains variable amounts of camphor (9.16 %) #16: Gallicin, a new germacranolide, sesquiterpene lactone, from Artemisia. rnaritirna gallica Willd. It can be converted to the dihydrosantamarin by a biogenetic cyclization process.

Endpoint Studies

Genotoxicity

Composition #1: Thaeter, K. Detection and estimation of santonin in the flower buds of artemisia maritima. archiv der pharmazie (weinheim, germany), 1897, vol. 235, p. 401–14. .

Language:

English (en)
Plant part:

Bud (as part-nature) (A066Z)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether
Substance:

santonin (RF-00003572-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.26-2.78
Internal remarks:

Santonin in flower buds

Composition #2: Spiridonova, S. Essential oils from grass. byull. nauch.-issledovatel. khim.-farm. inst., 1930, p. 8–9. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

cooling
Substance:

Camphor (RF-00003986-PAR)
Additional substance description:

The liquid left after the removal of camphor had 61.51% (hydroxylamine), 44.80% (semicarbazide)
Analytical method code:

Chromatographic tests (F015A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

36
Internal remarks:

Camphor, hydroxylamine, semicarbazide in aerial parts

Composition #3: Dionis'ev, D. E., Chernomaz, E. E. Investigation of the origin of poison in some wild plants. uchenye zapiski rostov. na/donu gosudarst. univ. im. molotova, 1938, vol. No. 9, p. 66–79. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Alkaloids (RF-00004360-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids were detected in Artemisia maritima

Composition #4: Dionis'ev, D. E., Chernomaz, E. E. Investigation of the origin of poison in some wild plants. uchenye zapiski rostov. na/donu gosudarst. univ. im. molotova, 1938, vol. No. 9, p. 66–79. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Saponins (RF-00004333-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

A saponin was detected,but not characterized in Artemisia maritima

Composition #5: Wahid, M. A., Samiullah. Standardization of active principles of indigenous pharmacopoeial drugs found in West Pakistan. pakistan journal of scientific and industrial research, 1960, vol. 3, p. 228–30. .

Language:

English (en)
Plant part:

Bud (as part-nature) (A066Z)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

santonin (RF-00003572-PAR)
Result unit:

Gram/100 gram (G013A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.71
Internal remarks:

Santonin was dose in buds (0.71%)

Composition #6: Wahid, M. A., Samiullah. Standardization of active principles of indigenous pharmacopoeial drugs found in West Pakistan. pakistan journal of scientific and industrial research, 1960, vol. 3, p. 228–30. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

santonin (RF-00003572-PAR)
Result unit:

Gram/100 gram (G013A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.81
Internal remarks:

Santonin was dosed in leaves (1.81%)

Composition #7: Mathela, C. S., Kharkwal, H., Shah, G. C. Essential oil composition of some Himalayan Artemisia species. journal of essential oil research, 1994, vol. 6, no. 4, p. 345–8. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.54
Internal remarks:

1,8-cineole in aerial parts

Composition #8: Mathela, C. S., Kharkwal, H., Shah, G. C. Essential oil composition of some Himalayan Artemisia species. journal of essential oil research, 1994, vol. 6, no. 4, p. 345–8. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

alpha-thujone (RF-00003676-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

63.25
Internal remarks:

Alpha -thujone in aerial parts

Composition #9: Jaitak, Vikas., Singh, Bikram., Kaul, V. K. Variability of volatile constituents in Artemisia maritima in western Himalaya . natural product research, 2008, vol. 22, no. 7, p. 565–568. DOI: 10.1080/14786410701592653. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Gram/100 gram (G013A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0-1.21
Internal remarks:

Beta-myrcene variable levels (0.0-1.21 %) have been detected in the essential oil of te aerial part of Artemisia maritima

Composition #10: Jaitak, Vikas., Singh, Bikram., Kaul, V. K. Variability of volatile constituents in Artemisia maritima in western Himalaya . natural product research, 2008, vol. 22, no. 7, p. 565–568. DOI: 10.1080/14786410701592653. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Gram/100 gram (G013A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

23.8-44.2
Internal remarks:

1,8-cineole variable levels (23.8-44.2%) have been detected in the essential oil of the aerial part of Artemisia maritima

Composition #11: Jaitak, Vikas., Singh, Bikram., Kaul, V. K. Variability of volatile constituents in Artemisia maritima in western Himalaya . natural product research, 2008, vol. 22, no. 7, p. 565–568. DOI: 10.1080/14786410701592653. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

(-)-camphor (RF-00003469-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Gram/100 gram (G013A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0-9.2
Internal remarks:

Camphor variable levels (0.0-9.2 %) have been detected in the essential oil of the aerial part of Artemisia maritima

Composition #12: Pandey, Vineeta., Verma, Ram Swaroop., Chauhan, Amit., Tiwari, Rakesh. Compositional characteristics of the volatile oils of three Artemisia spp. from western Himalaya . journal of essential oil research, 2015, vol. 27, no. 2, p. 107–114. DOI: 10.1080/10412905.2014.987927. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

alpha-thujone (RF-00003676-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Gram/100 gram (G013A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

63.2-72.1
Internal remarks:

The essential oil of Artemisia maritima L. contains variable amounts of alpha-tujone (63-2-72.1 %)

Composition #13: Pandey, Vineeta., Verma, Ram Swaroop., Chauhan, Amit., Tiwari, Rakesh. Compositional characteristics of the volatile oils of three Artemisia spp. from western Himalaya . journal of essential oil research, 2015, vol. 27, no. 2, p. 107–114. DOI: 10.1080/10412905.2014.987927. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

beta-thujone (RF-00003712-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Gram/100 gram (G013A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

8.4
Internal remarks:

The essential oil of Artemisia maritima L. contains variable amounts of beta-tujone (8.4 %)

Composition #14: Pandey, Vineeta., Verma, Ram Swaroop., Chauhan, Amit., Tiwari, Rakesh. Compositional characteristics of the volatile oils of three Artemisia spp. from western Himalaya . journal of essential oil research, 2015, vol. 27, no. 2, p. 107–114. DOI: 10.1080/10412905.2014.987927. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Gram/100 gram (G013A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.6-44.2
Internal remarks:

The essential oil of Artemisia maritima L. contains variable amounts of 1,8-cineole (1.6-44.2 %)

Composition #15: Pandey, Vineeta., Verma, Ram Swaroop., Chauhan, Amit., Tiwari, Rakesh. Compositional characteristics of the volatile oils of three Artemisia spp. from western Himalaya . journal of essential oil research, 2015, vol. 27, no. 2, p. 107–114. DOI: 10.1080/10412905.2014.987927. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

(-)-camphor (RF-00003469-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Gram/100 gram (G013A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

9.16
Internal remarks:

The essential oil of Artemisia maritima L. contains variable amounts of camphor (9.16 %)

Composition #16: GONZALEZ, AG., BERMEJO, J., MANSILLA, H., GALINDO, A., AMARO, JM., MASSANET, GM. CHEMISTRY OF COMPOSITAE .38. STRUCTURE AND ABSOLUTE-CONFIGURATION OF GALLICIN, A NEW GERMACRANOLIDE FROM ARTEMISIA . journal of the chemical society-perkin transactions 1, 1978, no. 10, p. 1243–1246. DOI: 10.1039/p19780001243. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Germacranolide (RF-00011355-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Gallicin, a new germacranolide, sesquiterpene lactone, from Artemisia. rnaritirna gallica Willd. It can be converted to the dihydrosantamarin by a biogenetic cyclization process.