EFSA Compendium of Botanicals

Draft - work in progress

Artemisia frigida Willd.

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 765
Number of processed references:: 8

Compositions

#1: Camphor #2: 1,8-Cineole #3: Myrcene #4: Dehydrocostuslactone, Dihydro dehydrocostuslactone #5: Coumarins (7-hydroxy coumarin, 7-methoxy coumarin, 6, 7-dihydroxy coumarin, 7-hydroxy-5, 6-dimethoxy coumarin) #6: 1,8-Cineole #7: Camphor #8: Myrcene #9: alpha-Thujone #10: beta-Thujone #11: Piperitone #12: Sesquiterpene lactones #13: 1,8-Cineole #14: santonin in leaves #15: Sesquiterpene lactones (1,10,-alpha-expoxy-8-alpha-hydroxyachillin, anhydrogrossmisin, canin, ridentin, ridentin-B, artecanin, 8a-hydroxyachillin)

Endpoint Studies

#1: lamb - food intake inhibition

Genotoxicity

Composition #1: Liu, Xiao-lan., Zhou, Jian-bo., Tao, Yan-duo., Shao, Yun. Analysis of chemical compositions of volatile oil in Artemisia frigida. fenxi shiyanshi, 2008, vol. 27, no. 3, p. 25–29. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.261
Internal remarks:

Camphor

Composition #2: Liu, Xiao-lan., Zhou, Jian-bo., Tao, Yan-duo., Shao, Yun. Analysis of chemical compositions of volatile oil in Artemisia frigida. fenxi shiyanshi, 2008, vol. 27, no. 3, p. 25–29. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.6
Internal remarks:

1,8-Cineole

Composition #3: Liu, Xiao-lan., Zhou, Jian-bo., Tao, Yan-duo., Shao, Yun. Analysis of chemical compositions of volatile oil in Artemisia frigida. fenxi shiyanshi, 2008, vol. 27, no. 3, p. 25–29. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.201
Internal remarks:

Myrcene

Composition #4: Chen, Jinjun., Wang, Siming., Li, Cunfang., Zhang, Manli., Dong, Mei., Shi, Qingwen. Studies on the inhibitory effects of sesquiterpenoids from Artemisia frigida on the proliferation activity of human tumor cell lines and the structure-activity relationship. zhongyao yaoli yu linchuang, 2011, vol. 27, no. 2, p. 24–26. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

Dehydrocostuslactone, Dihydro dehydrocostuslactone
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Dehydrocostuslactone, Dihydro dehydrocostuslactone

Composition #5: Wang, Q.-H., Wang, J.-H., Eerdunbagen., Tana. Chemical constituents of Artemisia frigida. chinese traditional and herbal drugs, 2009, vol. 40, no. 10, p. 1540–1543. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3, EtOAc
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

7-hydroxy coumarin, 7-methoxy coumarin, 6, 7-dihydroxy coumarin, 7-hydroxy-5, 6-dimethoxy coumarin
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins (7-hydroxy coumarin, 7-methoxy coumarin, 6, 7-dihydroxy coumarin, 7-hydroxy-5, 6-dimethoxy coumarin)

Composition #6: Korolyuk, E. A., Tkachev, A. V. Chemical composition of the essential oil from two wormwood species Artemisia frigida and Artemisia argyrophylla . russian journal of bioorganic chemistry, 2010, vol. 36, no. 7, p. 884–893. DOI: 10.1134/S1068162010070162. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

8.9-33.8
Internal remarks:

1,8-Cineole

Composition #7: Korolyuk, E. A., Tkachev, A. V. Chemical composition of the essential oil from two wormwood species Artemisia frigida and Artemisia argyrophylla . russian journal of bioorganic chemistry, 2010, vol. 36, no. 7, p. 884–893. DOI: 10.1134/S1068162010070162. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.7-40.0
Internal remarks:

Camphor

Composition #8: Korolyuk, E. A., Tkachev, A. V. Chemical composition of the essential oil from two wormwood species Artemisia frigida and Artemisia argyrophylla . russian journal of bioorganic chemistry, 2010, vol. 36, no. 7, p. 884–893. DOI: 10.1134/S1068162010070162. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.3-3.4
Internal remarks:

Myrcene

Composition #9: Korolyuk, E. A., Tkachev, A. V. Chemical composition of the essential oil from two wormwood species Artemisia frigida and Artemisia argyrophylla . russian journal of bioorganic chemistry, 2010, vol. 36, no. 7, p. 884–893. DOI: 10.1134/S1068162010070162. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

alpha-thujone (RF-00003676-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.0-12.5
Internal remarks:

alpha-Thujone

Composition #10: Korolyuk, E. A., Tkachev, A. V. Chemical composition of the essential oil from two wormwood species Artemisia frigida and Artemisia argyrophylla . russian journal of bioorganic chemistry, 2010, vol. 36, no. 7, p. 884–893. DOI: 10.1134/S1068162010070162. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

beta-thujone (RF-00003712-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.1-6.6
Internal remarks:

beta-Thujone

Composition #11: Korolyuk, E. A., Tkachev, A. V. Chemical composition of the essential oil from two wormwood species Artemisia frigida and Artemisia argyrophylla . russian journal of bioorganic chemistry, 2010, vol. 36, no. 7, p. 884–893. DOI: 10.1134/S1068162010070162. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

l-Piperitone (RF-00007699-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.1-2.0
Internal remarks:

Piperitone

Composition #12: Wang, Qing-Hu., Sha, Yi., Ao, Wu-Li-Ji., Wang, Xiu-Lan., Bao, Xiao-Hua., Li, Wen., Wang, Jin-Hui. Two new sesquiterpene lactone glycosides from Artemisia frigida Willd.. journal of asian natural products research, 2011, vol. 13, no. 7, p. 645–651. DOI: 10.1080/10286020.2011.584309. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethyl acetate
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sesquiterpene lactones

Composition #13: Zhang, Rumin., Zhang, Wenguang., Zuo, Zhaojiang., Li, Rui., Wu, Jianhua., Gao, Yan. Inhibition effects of volatile organic compounds from Artemisia frigida Willd. on the pasture grass intake by lambs . small ruminant research, 2014, vol. 121, no. 2-3, p. 248–254. DOI: 10.1016/j.smallrumres.2014.06.001. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Dynamic headspace
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Analytical method - additional description:

D-HS-GC-MS
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

39.18
Internal remarks:

1,8-Cineole

Composition #14: Sakipova, Zuriyadda., Wong, Nikki Siu Hai., Bekezhanova, Tolkyn., Sadykova., Shukirbekova, Alma., Boylan, Fabio. Quantification of santonin in eight species of Artemisia from Kazakhstan by means of HPLC-UV: Method development and validation . plos one, 2017, vol. 12, no. 3 . DOI: 10.1371/journal.pone.0173714. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

merthanol, chloroform
Substance:

santonin (RF-00003572-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

NMR
Result unit:

Gram/100 gram (G013A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.22
Internal remarks:

santonin in leaves

Composition #15: LIU, YL., MABRY, TJ. SESQUITERPENE LACTONES FROM ARTEMISIA-FRIGIDA. journal of natural products, 1981, vol. 44, no. 6, p. 722–728. DOI: 10.1021/np50018a020. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH/H2O
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

1,10,-alpha-expoxy-8-alpha-hydroxyachillin, anhydrogrossmisin, canin, ridentin, ridentin-B, artecanin, 8a-hydroxyachillin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

TLC, MS
Result expression:

Dry matter (B002A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sesquiterpene lactones (1,10,-alpha-expoxy-8-alpha-hydroxyachillin, anhydrogrossmisin, canin, ridentin, ridentin-B, artecanin, 8a-hydroxyachillin)

Endpoint study #1: Zhang, Rumin., Zhang, Wenguang., Zuo, Zhaojiang., Li, Rui., Wu, Jianhua., Gao, Yan. Inhibition effects of volatile organic compounds from Artemisia frigida Willd. on the pasture grass intake by lambs . small ruminant research, 2014, vol. 121, no. 2-3, p. 248–254. DOI: 10.1016/j.smallrumres.2014.06.001. [DOI link]

Study relevance:

Animal (target species) health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Fresh (A166Y)
Additional plant/substance description:

Fresh pasture herb
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

Sheep (as animal) (A057G)
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

7.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

3
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Kilogram (G167A)
Effect concentration:

3
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

"food intake by lambs according feeding time and feeding rate were inhibited markedly"
Effect or parameter linked to the endpoint:

food consumption (CHD007BE)
Internal remarks:

lamb - food intake inhibition