EFSA Compendium of Botanicals

Draft - work in progress

Aristolochia serpentaria L.

Family:: Aristolochiaceae
Approval state:: Approved
Number of articles retrieved:: 29
Number of processed references:: 2

Compositions

#1: aristolactone in roots and rhizomes #2: aristolochic acid in roots and rhizomes #3: aristolochic acid I and II in unspecified plant part

Endpoint Studies

Genotoxicity

Composition #1: Coutts, R. T., Stenlake, J. B., Williams, W. D. The chemistry of the Aristolochia species. V. Comparative study of acidic and basic constituents of Aristolochia reticulata, Aristolochia serpentaria, Aristolochia longa, and Aristolochia indica. journal of pharmacy and pharmacology, 1959, vol. 11, p. 607–17. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dilute HCl
Substance:

Aristolactone (RF-00003904-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

UV absorption spectrometry
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.091
Internal remarks:

aristolactone in roots and rhizomes

Composition #2: Coutts, R. T., Stenlake, J. B., Williams, W. D. The chemistry of the Aristolochia species. V. Comparative study of acidic and basic constituents of Aristolochia reticulata, Aristolochia serpentaria, Aristolochia longa, and Aristolochia indica. journal of pharmacy and pharmacology, 1959, vol. 11, p. 607–17. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

dilute HCl
Substance:

Aristolochia (RF-00000498-VET)
Additional substance description:

Aristolochic acid
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

UV absorption spectrometry
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.046 - 0.92
Internal remarks:

aristolochic acid in roots and rhizomes

Composition #3: Heinrich, Michael., Chan, Jennifer., Wanke, Stefan., Neinhuis, Christoph., Simmonds, Monique S. J. Local uses of Aristolochia species and content of nephrotoxic aristolochic acid 1 and 2-A global assessment based on bibliographic sources . journal of ethnopharmacology, 2009, vol. 125, no. 1, p. 108–144. DOI: 10.1016/j.jep.2009.05.028. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

Aristolochia (RF-00000498-VET)
Additional substance description:

aristolochic acid I and II
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

aristolochic acid I and II in unspecified plant part