EFSA Compendium of Botanicals

Draft - work in progress

Aristolochia rotunda L.

Family:: Aristolochiaceae
Approval state:: Approved
Number of articles retrieved:: 22
Number of processed references:: 2

Compositions

#1: Aristolactam #2: Aristolochic acid I and II #3: Aristolactams N-glucosides in roots

Endpoint Studies

Genotoxicity

Composition #1: Carboni, Salvatore., Livi, Oreste., Segnini, Domenico., Mazzanti, Luciano. Constituents of Aristolochia rotunda. gazzetta chimica italiana, 1966, vol. 96, no. 5, p. 641–61. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

aristolactam (RF-00003693-PAR)
Additional substance description:

Aristolochic acid i and II
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Aristolactam

Composition #2: Carboni, Salvatore., Livi, Oreste., Segnini, Domenico., Mazzanti, Luciano. Constituents of Aristolochia rotunda. gazzetta chimica italiana, 1966, vol. 96, no. 5, p. 641–61. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Aristolochia (RF-00000498-VET)
Additional substance description:

Aristolochic acid i and II
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Aristolochic acid I and II

Composition #3: Pistelli, L., Nieri, E., Bilia, AR., Marsili, A., Morelli, I. Further phenanthrene derivatives from Aristolochia rotunda. international journal of pharmacognosy, 1995, vol. 33, no. 4, p. 362–364. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH, Me2CO, n-hexane, Column Chromatograpfy
Substance:

aristolactam (RF-00003693-PAR)
Additional substance description:

Aristolactams N-glucosides (Illa N-P-Dglucoside and aristolactam I N-P-D-glucosid)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

H-NMR
Result unit:

Milligram (G155A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

13.5 - 14
Internal remarks:

Aristolactams N-glucosides in roots