EFSA Compendium of Botanicals

Draft - work in progress

Aristolochia fontanesii Boiss. & Reut. // Aristolochia longa L.

Family:: Aristolochiaceae
Approval state:: Approved
Number of articles retrieved:: 48
Number of processed references:: 2

Compositions

#1: Tannins in root (acetone extract) #2: Tannins in fruits (methanol extract) #3: Tannins in roots (metanol extract) #4: Tannins in fruits (acetone extraction) #5: Tannins in aereal part (water extraction) #6: Tannins in fruit (aqueous extraction) #7: Tannins in aereal part (metanol extract) #8: Tannins in aereal parts (acetone extract)

Endpoint Studies

#1: subchronic toxicity in mice (atypical locomotion, anorexia, asthenia, ataxia, diarrhea, urination)

Genotoxicity

Composition #1: Merouani, N., Belhattab, R., Sahli, F. EVALUATION OF THE BIOLOGICAL ACTIVITY OF ARISTOLOCHIA LONGA L. EXTRACTS. international journal of pharmaceutical sciences and research, 2017, vol. 8, no. 5, p. 1978–1992. DOI: 10.13040/IJPSR.0975-8232.8(5).1978-92. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

Tannins (RF-00004337-PAR)
Result unit:

Microgram (G283A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

14.98
Internal remarks:

Tannins in root (acetone extract)

Composition #2: Merouani, N., Belhattab, R., Sahli, F. EVALUATION OF THE BIOLOGICAL ACTIVITY OF ARISTOLOCHIA LONGA L. EXTRACTS. international journal of pharmaceutical sciences and research, 2017, vol. 8, no. 5, p. 1978–1992. DOI: 10.13040/IJPSR.0975-8232.8(5).1978-92. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Tannins (RF-00004337-PAR)
Result unit:

Microgram (G283A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

155.46
Internal remarks:

Tannins in fruits (methanol extract)

Composition #3: Merouani, N., Belhattab, R., Sahli, F. EVALUATION OF THE BIOLOGICAL ACTIVITY OF ARISTOLOCHIA LONGA L. EXTRACTS. international journal of pharmaceutical sciences and research, 2017, vol. 8, no. 5, p. 1978–1992. DOI: 10.13040/IJPSR.0975-8232.8(5).1978-92. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Tannins (RF-00004337-PAR)
Result unit:

Microgram (G283A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

206.93
Internal remarks:

Tannins in roots (metanol extract)

Composition #4: Merouani, N., Belhattab, R., Sahli, F. EVALUATION OF THE BIOLOGICAL ACTIVITY OF ARISTOLOCHIA LONGA L. EXTRACTS. international journal of pharmaceutical sciences and research, 2017, vol. 8, no. 5, p. 1978–1992. DOI: 10.13040/IJPSR.0975-8232.8(5).1978-92. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

Tannins (RF-00004337-PAR)
Result unit:

Microgram (G283A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

130.8
Internal remarks:

Tannins in fruits (acetone extraction)

Composition #5: Merouani, N., Belhattab, R., Sahli, F. EVALUATION OF THE BIOLOGICAL ACTIVITY OF ARISTOLOCHIA LONGA L. EXTRACTS. international journal of pharmaceutical sciences and research, 2017, vol. 8, no. 5, p. 1978–1992. DOI: 10.13040/IJPSR.0975-8232.8(5).1978-92. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acqueos
Substance:

Tannins (RF-00004337-PAR)
Result unit:

Microgram (G283A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

54.4
Internal remarks:

Tannins in aereal part (water extraction)

Composition #6: Merouani, N., Belhattab, R., Sahli, F. EVALUATION OF THE BIOLOGICAL ACTIVITY OF ARISTOLOCHIA LONGA L. EXTRACTS. international journal of pharmaceutical sciences and research, 2017, vol. 8, no. 5, p. 1978–1992. DOI: 10.13040/IJPSR.0975-8232.8(5).1978-92. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acqueos
Substance:

Tannins (RF-00004337-PAR)
Result unit:

Microgram (G283A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

14.14
Internal remarks:

Tannins in fruit (aqueous extraction)

Composition #7: Merouani, N., Belhattab, R., Sahli, F. EVALUATION OF THE BIOLOGICAL ACTIVITY OF ARISTOLOCHIA LONGA L. EXTRACTS. international journal of pharmaceutical sciences and research, 2017, vol. 8, no. 5, p. 1978–1992. DOI: 10.13040/IJPSR.0975-8232.8(5).1978-92. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Tannins (RF-00004337-PAR)
Result unit:

Microgram (G283A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

99.36
Internal remarks:

Tannins in aereal part (metanol extract)

Composition #8: Merouani, N., Belhattab, R., Sahli, F. EVALUATION OF THE BIOLOGICAL ACTIVITY OF ARISTOLOCHIA LONGA L. EXTRACTS. international journal of pharmaceutical sciences and research, 2017, vol. 8, no. 5, p. 1978–1992. DOI: 10.13040/IJPSR.0975-8232.8(5).1978-92. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

Tannins (RF-00004337-PAR)
Result unit:

Microgram (G283A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

132.3
Internal remarks:

Tannins in aereal parts (acetone extract)

Endpoint study #1: Benzakour, Ghita., Benkirane, Nouhad., Amrani, Mariam., Oudghiri, Mounia. Immunostimulatory potential of Aristolochia longa L. induced toxicity on liver, intestine and kidney in mice. journal of toxicology and environmental health sciences, 2011, vol. 3, no. 8, p. 214–222. .

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Type of toxicological test:

subchronic (CHD013TT)
Limit test:

No
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

Swiss (CHD005ST)
Sex:

No data
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration:

3.0
Unit of exposure duration:

Week (G205A)
Number of organisms dosed:

12
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Toxicity equivalency factor (CHD001EP)
Concentration unit:

Grams per kilogram body weight (G226A)
Effect concentration:

2.5
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

neurologic: Central Nervous System (TT035A)
Effect description:

atypical locomotion, anorexia, asthenia, ataxia, diarrhea, urination
Effect or parameter linked to the endpoint:

behaviour (CHD001BE)
Internal remarks:

subchronic toxicity in mice (atypical locomotion, anorexia, asthenia, ataxia, diarrhea, urination)