EFSA
ecomole
vscht
  2. Aristolochia fangchi Y.C.Wu ex L.D.Chow & S.M.Hwang

Aristolochia fangchi Y.C.Wu ex L.D.Chow & S.M.Hwang

Family:
Aristolochiaceae
Approval state:
Approved
Number of articles retrieved:
230
Number of processed references:
6
Compositions
#1: aristolochic acid in roots - water extract #2: aristolochic acid in roots - methanol extract #3: alkaloids (acutumidine, stepharine, cyclanoline, isotrilobine) in the root #4: magnoflorine in the root #5: sinomenine in the root #6: acutumine in the root #7: fangchinoline in the root #8: aristolactam in the root #9: aristolochic acid in the root #10: berbamine in the root #11: tetrandrine in the root #12: isotetrandrine, in the root #13: Magnoflorine #14: Aristolochic acid
Endpoint Studies
#1: nephrotoxicity in rats: acute renal tubular putrescence and renal interstitial hyperplasia; single dose of 125, 62.5, 15.2 mg​/kg #2: nephrotoxicity in rats: High-dose Aristolochia fangchi can induce renal lesion and its seriousness is correspondent to the lasting of administration. Aristolochia fangchi may also have toxicity on liver. #3: case reports: nephropathy and cancerogenity
Genotoxicity
Composition #1: Zhao, Zhong-Zhen., Liang, Zhi-Tao., Jiang, Zhi-Hong., Leung, Kelvin Sze-Yin., Chan, Chi-Leung., Chan, Hon-Yee., Sin, Jaime., Man, Tim-On., Law, Kwok-Wai. Comparative study on the aristolochic acid I content of Herba Asari for safe use. phytomedicine, 2008, vol. 15, no. 9, p. 741–748. .
Composition #2: Zhao, Zhong-Zhen., Liang, Zhi-Tao., Jiang, Zhi-Hong., Leung, Kelvin Sze-Yin., Chan, Chi-Leung., Chan, Hon-Yee., Sin, Jaime., Man, Tim-On., Law, Kwok-Wai. Comparative study on the aristolochic acid I content of Herba Asari for safe use. phytomedicine, 2008, vol. 15, no. 9, p. 741–748. .
Composition #3: Huang, Wen-Ying., Su, Cheng-Hung., Sheu, Shuenn-Jyi. Separation and identification of the constituents in Fangchi Radix of different origins . journal of food and drug analysis, 2006, vol. 14, no. 4, p. 357–367. .
Composition #4: Huang, Wen-Ying., Su, Cheng-Hung., Sheu, Shuenn-Jyi. Separation and identification of the constituents in Fangchi Radix of different origins . journal of food and drug analysis, 2006, vol. 14, no. 4, p. 357–367. .
Composition #5: Huang, Wen-Ying., Su, Cheng-Hung., Sheu, Shuenn-Jyi. Separation and identification of the constituents in Fangchi Radix of different origins . journal of food and drug analysis, 2006, vol. 14, no. 4, p. 357–367. .
Composition #6: Huang, Wen-Ying., Su, Cheng-Hung., Sheu, Shuenn-Jyi. Separation and identification of the constituents in Fangchi Radix of different origins . journal of food and drug analysis, 2006, vol. 14, no. 4, p. 357–367. .
Composition #7: Huang, Wen-Ying., Su, Cheng-Hung., Sheu, Shuenn-Jyi. Separation and identification of the constituents in Fangchi Radix of different origins . journal of food and drug analysis, 2006, vol. 14, no. 4, p. 357–367. .
Composition #8: Huang, Wen-Ying., Su, Cheng-Hung., Sheu, Shuenn-Jyi. Separation and identification of the constituents in Fangchi Radix of different origins . journal of food and drug analysis, 2006, vol. 14, no. 4, p. 357–367. .
Composition #9: Huang, Wen-Ying., Su, Cheng-Hung., Sheu, Shuenn-Jyi. Separation and identification of the constituents in Fangchi Radix of different origins . journal of food and drug analysis, 2006, vol. 14, no. 4, p. 357–367. .
Composition #10: Huang, Wen-Ying., Su, Cheng-Hung., Sheu, Shuenn-Jyi. Separation and identification of the constituents in Fangchi Radix of different origins . journal of food and drug analysis, 2006, vol. 14, no. 4, p. 357–367. .
Composition #11: Huang, Wen-Ying., Su, Cheng-Hung., Sheu, Shuenn-Jyi. Separation and identification of the constituents in Fangchi Radix of different origins . journal of food and drug analysis, 2006, vol. 14, no. 4, p. 357–367. .
Composition #12: Huang, Wen-Ying., Su, Cheng-Hung., Sheu, Shuenn-Jyi. Separation and identification of the constituents in Fangchi Radix of different origins . journal of food and drug analysis, 2006, vol. 14, no. 4, p. 357–367. .
Composition #13: Sim, Hee-Jung., Kim, Ji Hee., Lee, Kang Ro., Hong, Jongki. Simultaneous Determination of Structurally Diverse Compounds in Different Fangchi Species by UHPLC-DAD and UHPLC-ESI-MS/MS . molecules, 2013, vol. 18, no. 5, p. 5235–5250. DOI: 10.3390/molecules18055235. [DOI link]
Composition #14: Sim, Hee-Jung., Kim, Ji Hee., Lee, Kang Ro., Hong, Jongki. Simultaneous Determination of Structurally Diverse Compounds in Different Fangchi Species by UHPLC-DAD and UHPLC-ESI-MS/MS . molecules, 2013, vol. 18, no. 5, p. 5235–5250. DOI: 10.3390/molecules18055235. [DOI link]
Endpoint study #1: Liu, Sha., Du, Guiyou., Li, Li., Xiao, Yongqing. Toxicokinetics and distribution of Aristolochia Fangchi in rats. zhongyao yaoli yu linchuang, 2006, vol. 22(3-4), p. 90–94. .
Endpoint study #2: Liang, Qi., Ni, Cheng., Xie, Ming., Zhang, Qi., Zhang, Yan-Xia., Yan, Xian-Zhong., Yang, Mei-Juan., Peng, Shuang-Qing., Zhang, Yu-Zhong. Nephrotoxicity study of Aristolochia fangchi in rats by metabonomics .. zhong xi yi jie he xue bao = journal of chinese integrative medicine, 2009, vol. 7, no. 8, p. 746–52. DOI: 10.3736/jcim20090808. [DOI link]
Endpoint study #3: Schmeiser, Heinz H., Nortier, Joelle L., Singh, Rajinder., da Costa, Goncalo Gamboa., Sennesael, Jacques., Cassuto-Viguier, Elisabeth., Ambrosetti, Damien., Rorive, Sandrine., Pozdzik, Agnieszka., Phillips, David H., Stiborova, Marie., Arlt, Volker M. Exceptionally long- term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy . international journal of cancer, 2014, vol. 135, no. 2, p. 502–507. DOI: 10.1002/ijc.28681. [DOI link]