EFSA Compendium of Botanicals

Draft - work in progress

Argyreia nervosa (Burm.f.) Bojer // Argyreia speciosa (L.f.) Sweet // Convolvulus speciosus L.f.

Family:: Convolvulaceae
Approval state:: Approved
Number of articles retrieved:: 225
Number of processed references:: 8

Compositions

#1: coumarins (roots) #2: phenylpropanoids (roots) #3: scopoletin, stigmasteryl p-hydroxycinnamate and hexadecanyl p-hydroxycinnamate #4: Lisergic acid in seeds #5: chanoclavine in seeds #6: elymoclavine in seeds #7: ergometrine in seeds #8: lysergic acid amide in seeds #9: Lysergic acid (SEED) #10: Ergine (SEED) #11: Ergometrine (SEED) #12: Lysergol (SEED) #13: Lysergylalanine (SEED) #14: Chanoclavine-I and chanoclavine-II (SEED) #15: Egometrine derrivative: Methylergometrine (SEED) #16: Ergine (seeds) #17: Isoergine (seeds) #18: isolysergic acid amide (seed) #19: lysergic acid amide (seed)

Endpoint Studies

#1: hallucination, anxiety, nausea, vomiting #2: elevated blood pressure, nausea, vomiting, psychological effects

Genotoxicity

Composition #1: Galani, Varsha J., Patel, Bharatkumar G. Psychotropic activity of Argyreia speciosa roots in experimental animals. . ayu, 2011, vol. 32, no. 3, p. 380–4. DOI: 10.4103/0974-8520.93919. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Hydroalcoholic
Substance:

coumarins (RF-00004351-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

coumarins (roots)

Composition #2: Galani, Varsha J., Patel, Bharatkumar G. Psychotropic activity of Argyreia speciosa roots in experimental animals. . ayu, 2011, vol. 32, no. 3, p. 380–4. DOI: 10.4103/0974-8520.93919. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Hydroalcoholic
Substance:

phenylpropanoids (RF-00004367-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

phenylpropanoids (roots)

Composition #3: Srivastava, A., Shukla, YN. Aryl esters and a coumarin from Aygyreia speciosa. indian journal of chemistry section b-organic chemistry including medicinal chemistry, 1998, vol. 37, no. 2, p. 192–194. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

scopoletin (RF-00004048-PAR)
Additional substance description:

scopoietin, stigmasteryl p-hydroxycinnamate and hexadecanyl p-hydroxycinnamate
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

scopoletin, stigmasteryl p-hydroxycinnamate and hexadecanyl p-hydroxycinnamate

Composition #4: Borsutzky, M., Passie, T., Paetzold, W., Emrich, HM., Schneider, U. Hawaiian baby woodrose: (Psycho-) pharmacological effects of the seeds of Argyreia nervosa. A case-orientated demonstration . nervenarzt, 2002, vol. 73, no. 9, p. 892–896. DOI: 10.1007/s00115-002-1374-4. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Substance:

lysergic acid (RF-00003915-PAR)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

8.20
Internal remarks:

Lisergic acid in seeds

Composition #5: Borsutzky, M., Passie, T., Paetzold, W., Emrich, HM., Schneider, U. Hawaiian baby woodrose: (Psycho-) pharmacological effects of the seeds of Argyreia nervosa. A case-orientated demonstration . nervenarzt, 2002, vol. 73, no. 9, p. 892–896. DOI: 10.1007/s00115-002-1374-4. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Substance:

Chanoclavine-1 (RF-00000381-TOX)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.62
Internal remarks:

chanoclavine in seeds

Composition #6: Borsutzky, M., Passie, T., Paetzold, W., Emrich, HM., Schneider, U. Hawaiian baby woodrose: (Psycho-) pharmacological effects of the seeds of Argyreia nervosa. A case-orientated demonstration . nervenarzt, 2002, vol. 73, no. 9, p. 892–896. DOI: 10.1007/s00115-002-1374-4. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Substance:

Elymoclavine (RF-00000384-TOX)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

elymoclavine in seeds

Composition #7: Borsutzky, M., Passie, T., Paetzold, W., Emrich, HM., Schneider, U. Hawaiian baby woodrose: (Psycho-) pharmacological effects of the seeds of Argyreia nervosa. A case-orientated demonstration . nervenarzt, 2002, vol. 73, no. 9, p. 892–896. DOI: 10.1007/s00115-002-1374-4. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Substance:

Ergometrine (RF-00000134-TOX)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

ergometrine in seeds

Composition #8: Kremer, Christian., Paulke, Alexander., Wunder, Cora., Toennes, Stefan W. Variable adverse effects in subjects after ingestion of equal doses of Argyreia nervosa seeds . forensic science international, 2012, vol. 214, no. 1-3, p. E6–E8. DOI: 10.1016/j.forsciint.2011.06.025. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

lysergic acid (RF-00003915-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Microgram/0,01 gram (G045A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.73-16.03
Internal remarks:

lysergic acid amide in seeds

Composition #9: Paulke, Alexander., Kremer, Christian., Wunder, Cora., Wurglics, Mario., Schubert-Zsilavecz, Manfred., Toennes, Stefan W. Studies on the alkaloid composition of the Hawaiian Baby Woodrose Argyreia nervosa, a common legal high . forensic science international, 2015, vol. 249, p. 281–293. DOI: 10.1016/j.forsciint.2015.02.011. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol:- water (60:40, v/v)
Substance:

lysergic acid (RF-00003915-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

high performance liquid chromatography– high resolution mass spectrometry (HPLC–HRMS/MS) technique
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lysergic acid (SEED)

Composition #10: Paulke, Alexander., Kremer, Christian., Wunder, Cora., Wurglics, Mario., Schubert-Zsilavecz, Manfred., Toennes, Stefan W. Studies on the alkaloid composition of the Hawaiian Baby Woodrose Argyreia nervosa, a common legal high . forensic science international, 2015, vol. 249, p. 281–293. DOI: 10.1016/j.forsciint.2015.02.011. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol:- water (60:40, v/v)
Substance:

Ergine (RF-00000385-TOX)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

high performance liquid chromatography– high resolution mass spectrometry (HPLC–HRMS/MS) technique
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Ergine (SEED)

Composition #11: Paulke, Alexander., Kremer, Christian., Wunder, Cora., Wurglics, Mario., Schubert-Zsilavecz, Manfred., Toennes, Stefan W. Studies on the alkaloid composition of the Hawaiian Baby Woodrose Argyreia nervosa, a common legal high . forensic science international, 2015, vol. 249, p. 281–293. DOI: 10.1016/j.forsciint.2015.02.011. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol:- water (60:40, v/v)
Substance:

Ergometrine (RF-00000134-TOX)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

high performance liquid chromatography– high resolution mass spectrometry (HPLC–HRMS/MS) technique
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Ergometrine (SEED)

Composition #12: Paulke, Alexander., Kremer, Christian., Wunder, Cora., Wurglics, Mario., Schubert-Zsilavecz, Manfred., Toennes, Stefan W. Studies on the alkaloid composition of the Hawaiian Baby Woodrose Argyreia nervosa, a common legal high . forensic science international, 2015, vol. 249, p. 281–293. DOI: 10.1016/j.forsciint.2015.02.011. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol:- water (60:40, v/v)
Substance:

Lysergol (RF-00000408-TOX)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

high performance liquid chromatography– high resolution mass spectrometry (HPLC–HRMS/MS) technique
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lysergol (SEED)

Composition #13: Paulke, Alexander., Kremer, Christian., Wunder, Cora., Wurglics, Mario., Schubert-Zsilavecz, Manfred., Toennes, Stefan W. Studies on the alkaloid composition of the Hawaiian Baby Woodrose Argyreia nervosa, a common legal high . forensic science international, 2015, vol. 249, p. 281–293. DOI: 10.1016/j.forsciint.2015.02.011. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol:- water (60:40, v/v)
Substance:

Ergot alkaloids (RF-00000133-TOX)
Additional substance description:

lysergylalanine
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

high performance liquid chromatography– high resolution mass spectrometry (HPLC–HRMS/MS) technique
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lysergylalanine (SEED)

Composition #14: Paulke, Alexander., Kremer, Christian., Wunder, Cora., Wurglics, Mario., Schubert-Zsilavecz, Manfred., Toennes, Stefan W. Studies on the alkaloid composition of the Hawaiian Baby Woodrose Argyreia nervosa, a common legal high . forensic science international, 2015, vol. 249, p. 281–293. DOI: 10.1016/j.forsciint.2015.02.011. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol:- water (60:40, v/v)
Substance:

Chanoclavine-1 (RF-00000381-TOX)
Additional substance description:

chanoclavine-I and chanoclavine-II
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

high performance liquid chromatography– high resolution mass spectrometry (HPLC–HRMS/MS) technique
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Chanoclavine-I and chanoclavine-II (SEED)

Composition #15: Paulke, Alexander., Kremer, Christian., Wunder, Cora., Wurglics, Mario., Schubert-Zsilavecz, Manfred., Toennes, Stefan W. Studies on the alkaloid composition of the Hawaiian Baby Woodrose Argyreia nervosa, a common legal high . forensic science international, 2015, vol. 249, p. 281–293. DOI: 10.1016/j.forsciint.2015.02.011. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol:- water (60:40, v/v)
Substance:

Ergometrine (RF-00000134-TOX)
Additional substance description:

Egometrine derrivative: methylergometrine
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

high performance liquid chromatography– high resolution mass spectrometry (HPLC–HRMS/MS) technique
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Egometrine derrivative: Methylergometrine (SEED)

Composition #16: HYLIN, JW., WATSON, DP. ERGOLINE ALKALOIDS IN TROPICAL WOOD ROSES. science, 1965, vol. 148, no. 3669, p. 499–&. DOI: 10.1126/science.148.3669.499. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform and ether
Substance:

Ergine (RF-00000385-TOX)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

TLC
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

780
Internal remarks:

Ergine (seeds)

Composition #17: HYLIN, JW., WATSON, DP. ERGOLINE ALKALOIDS IN TROPICAL WOOD ROSES. science, 1965, vol. 148, no. 3669, p. 499–&. DOI: 10.1126/science.148.3669.499. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform and ether
Substance:

Ergine (RF-00000385-TOX)
Additional substance description:

Isoergine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

TLC
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

555
Internal remarks:

Isoergine (seeds)

Composition #18: MILLER, MD. ISOLATION AND IDENTIFICATION OF LYSERGIC ACID AMIDE AND ISOLYSERGIC ACID AMIDE AS PRINCIPAL ERGOLINE ALKALOIDS IN ARGYREIA-NERVOSA, A TROPICAL WOOD ROSE . journal of the association of official analytical chemists, 1970, vol. 53, no. 1, p. 123–&. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

lysergic acid (RF-00003915-PAR)
Additional substance description:

isolysergic acid amide
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

TLC, UV and IR-spectrophotometery
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

isolysergic acid amide (seed)

Composition #19: MILLER, MD. ISOLATION AND IDENTIFICATION OF LYSERGIC ACID AMIDE AND ISOLYSERGIC ACID AMIDE AS PRINCIPAL ERGOLINE ALKALOIDS IN ARGYREIA-NERVOSA, A TROPICAL WOOD ROSE . journal of the association of official analytical chemists, 1970, vol. 53, no. 1, p. 123–&. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

lysergic acid (RF-00003915-PAR)
Additional substance description:

Lysergic acid amide
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

TLC, UV and IR-spectrophotometery
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.04
Internal remarks:

lysergic acid amide (seed)

Endpoint study #1: Simonienko, K., Waszkiewicz, N., Szulc, A. Psychoactive plant species - Actual list of plants prohibited in Poland Roślinne środki odurzajace - Aktualnie obowiazujaca lista w Polsce . psychiatria polska, 2013, vol. 47, no. 3, p. 499–510. .

Study relevance:

Human health
Substance:

lysergic acid (RF-00003915-PAR)
Type of toxicological test:

acute toxicity (CHD016TT)
Sex:

No data
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

6.0
Unit of exposure duration:

Hour (G099A)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

Neurologic (TT004A)
Effect description:

hallucination, anxiety, nausea, vomiting
Effect or parameter linked to the endpoint:

behaviour (CHD001BE)
Internal remarks:

hallucination, anxiety, nausea, vomiting

Endpoint study #2: Kremer, Christian., Paulke, Alexander., Wunder, Cora., Toennes, Stefan W. Variable adverse effects in subjects after ingestion of equal doses of Argyreia nervosa seeds . forensic science international, 2012, vol. 214, no. 1-3, p. E6–E8. DOI: 10.1016/j.forsciint.2011.06.025. [DOI link]

Study relevance:

Human health
Substance:

lysergic acid (RF-00003915-PAR)
Plant part:

Seed (as part-nature) (A066P)
Additional plant/substance description:

lysergic acid amide
Type of toxicological test:

study with volunteers (CHD056TT)
Tested organism:

Human (as organism) (A056J)
Sex:

Male/Female
Route of exposure:

ORAL: DRINKING WATER (OECD2229PL)
Number of organisms dosed:

4
Control groups used:

no data
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Micrograms per kilogram body weight (G224A)
Effect concentration:

5.88
Critical effect:

MUSCLO-SKELETAL (TOX13A)
Target tissue:

cardiovascular / haematological: Heart (TT011A)
Effect description:

elevated blood pressure, nausea and fatigue, vomiting, significant psychological effects, paranoid behavior, difficulties in verbal expression, heaviness in the legs
Effect or parameter linked to the endpoint:

neurology (CHD027BE)
Internal remarks:

elevated blood pressure, nausea, vomiting, psychological effects