Draft - work in progress
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- Argan (as plant) // Argania spinosa (L.) Skeels
Argan (as plant) // Argania spinosa (L.) Skeels
- Family:
- Sapotaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 474
- Number of processed references:
- 7
Composition #1: Khallouki, Farid., Haubner, Roswitha., Ricarte, Irvila., Erben, Gerhard., Klika, Karel., Ulrich, Cornelia M., Owen, Robert W. Identification of polyphenolic compounds in the flesh of Argan (Morocco) fruits. food chemistry, 2015, vol. 179, p. 191–198. .
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Hexane, MeOH, Column chromatography
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Substance:
3,4-Dihydroxybenzoic acid (RF-00008853-PAR)
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Analytical method code:
HPLC-MS/MS (F698A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
3,4-Dihydroxybenzoic acid in fruit
Composition #2: Khallouki, Farid., Haubner, Roswitha., Ricarte, Irvila., Erben, Gerhard., Klika, Karel., Ulrich, Cornelia M., Owen, Robert W. Identification of polyphenolic compounds in the flesh of Argan (Morocco) fruits. food chemistry, 2015, vol. 179, p. 191–198. .
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Hexane, MeOH, Column chromatography
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Substance:
p-coumaric acid (RF-00010717-PAR)
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Analytical method code:
HPLC-MS/MS (F698A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
p-Coumaric acid in fruit
Composition #3: Khallouki, Farid., Haubner, Roswitha., Ricarte, Irvila., Erben, Gerhard., Klika, Karel., Ulrich, Cornelia M., Owen, Robert W. Identification of polyphenolic compounds in the flesh of Argan (Morocco) fruits. food chemistry, 2015, vol. 179, p. 191–198. .
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-
Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Hexane, MeOH, Column chromatography
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Substance:
gallic acid (RF-00003821-PAR)
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Analytical method code:
HPLC-MS/MS (F698A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Gallic acid in fruit
Composition #4: Khallouki, Farid., Haubner, Roswitha., Ricarte, Irvila., Erben, Gerhard., Klika, Karel., Ulrich, Cornelia M., Owen, Robert W. Identification of polyphenolic compounds in the flesh of Argan (Morocco) fruits. food chemistry, 2015, vol. 179, p. 191–198. .
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Hexane, MeOH, Column chromatography
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Substance:
4-Hydroxybenzaldehyde (RF-00001976-PAR)
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Analytical method code:
HPLC-MS/MS (F698A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
p-Hydroxybenzaldehyde in fruit
Composition #5: Alaoui, A., Charrouf, Z., Soufiaoui, M., Carbone, V., Malorni, A., Pizza, C., Piacente, S. Triterpenoid saponins from the shells of Argania spinosa seeds. journal of agricultural and food chemistry, 2002, vol. 50, no. 16, p. 4600–4603. DOI: 10.1021/jf0200117.
[
DOI link]
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Plant part:
Husk (as part-nature) (A166J)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
MeOH
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Substance:
pentacyclic triterpene saponins (RF-00004334-PAR)
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Additional substance description:
oleanene saponins
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Analytical method - additional description:
NMR; MS
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
oleanene saponins in husk
Composition #6: El Fakhar, Nadia., Charrouf, Zoubida., Coddeville, Bernadette., Leroy, Yves., Michalski, Jean Claude., Guillaume, Dominique. New triterpenoid saponins from Argania spinosa. journal of natural medicines, 2007, vol. 61, no. 4, p. 375–380. DOI: 10.1007/s11418-007-0161-8.
[
DOI link]
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Plant part:
Bark (as part-nature) (A066X)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
MeOH
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Substance:
pentacyclic triterpene saponins (RF-00004334-PAR)
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Additional substance description:
arganines ( pentacyclic triterpene saponins )
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Analytical method - additional description:
NMR; EIMS
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Result expression:
Dry matter (B002A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
arganines (pentacyclic triterpene saponins) in bark
Composition #7: Henry, Max., Kowalczyk, Mariusz., Maldini, Mariateresa., Piacente, Sonia., Stochmal, Anna., Oleszek, Wieslaw. Saponin Inventory from Argania spinosa Kernel Cakes by Liquid Chromatography and Mass Spectrometry . phytochemical analysis, 2013, vol. 24, no. 6, p. 616–622. DOI: 10.1002/pca.2440.
[
DOI link]
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
hexane in a Soxhlet apparatus during 48 h, successively extracted with ethanol
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Substance:
pentacyclic triterpene saponins (RF-00004334-PAR)
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Additional substance description:
Arganines A-F
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Analytical method code:
LC-MS (F026A)
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Analytical method - additional description:
MS; NMR; UV
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Arganines A-F (kernel)
Composition #8: Henry, Max., Kowalczyk, Mariusz., Maldini, Mariateresa., Piacente, Sonia., Stochmal, Anna., Oleszek, Wieslaw. Saponin Inventory from Argania spinosa Kernel Cakes by Liquid Chromatography and Mass Spectrometry . phytochemical analysis, 2013, vol. 24, no. 6, p. 616–622. DOI: 10.1002/pca.2440.
[
DOI link]
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
hexane in a Soxhlet apparatus during 48 h, successively extracted with ethanol
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Substance:
pentacyclic triterpene saponins (RF-00004334-PAR)
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Additional substance description:
Tieghemelin
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Analytical method code:
LC-MS (F026A)
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Analytical method - additional description:
MS; NMR; UV
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Tieghemelin (from kernel)
Composition #9: El Amrani, Abdelaziz., Cayuela Sanchez, Jose Antonio., Jamal Eddine, Jamal. Chemical Composition of Moroccan Argania spinosa leaf Essential Oils Isolated by Supercritical CO2, Microwave and Hydrodistillation . journal of essential oil bearing plants, 2015, vol. 18, no. 5, p. 1138–1147. DOI: 10.1080/0972060X.2014.977563.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
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Additional extraction description:
microwave extraction and SFE
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Substance:
(-)-camphor (RF-00003469-PAR)
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Analytical method code:
GC-MS (F046A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
1.5-8.6
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Internal remarks:
Camphor in leaves
Composition #10: El Amrani, Abdelaziz., Cayuela Sanchez, Jose Antonio., Jamal Eddine, Jamal. Chemical Composition of Moroccan Argania spinosa leaf Essential Oils Isolated by Supercritical CO2, Microwave and Hydrodistillation . journal of essential oil bearing plants, 2015, vol. 18, no. 5, p. 1138–1147. DOI: 10.1080/0972060X.2014.977563.
[
DOI link]
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
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Additional extraction description:
microwave extraction and SFE
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Substance:
myrcene (RF-00003503-PAR)
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Analytical method code:
GC-MS (F046A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.9-5.8
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Internal remarks:
Myrcene in leaves
Composition #11: CHARROUF, Z., WIERUSZESKI, JM., FKIHTETOUANI, S., LEROY, Y., CHARROUF, M., FOURNET, B. TRITERPENOID SAPONINS FROM ARGANIA-SPINOSA. phytochemistry, 1992, vol. 31, no. 6, p. 2079–2086. DOI: 10.1016/0031-9422(92)80367-N.
[
DOI link]
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
EtOH
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Substance:
pentacyclic triterpene saponins (RF-00004334-PAR)
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Additional substance description:
Arganines A-F
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Analytical method - additional description:
MS; GC; HPLC
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Arganines A-F
Endpoint study
#1: Alaoui, Katim., Belabbes, Mohamed., Cherrah, Yahia., Hassar, Mohamed., Charrouf, Zoubida., Amarouch, Hamid., Roquebert, Jacques. Acute and chronic toxicity of saponins of Argania spinosa. annales pharmaceutiques francaises, 1998, vol. 56, no. 5, p. 213–219. .
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Study relevance:
Human health
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Substance:
Saponins (RF-00004333-PAR)
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Plant part:
Unspecified (A07XD)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
Water
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Type of toxicological test:
acute toxicity (CHD016TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Control groups used:
no data
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Endpoint measured:
Lethal dose rate in 50% of experimental organisms (CHD029EP)
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Concentration unit:
Milligram/kilogram (G061A)
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Effect concentration:
1300
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Critical effect:
NOT REPORTED (TOX17A)
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Effect description:
no data
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Effect or parameter linked to the endpoint:
no data (CHD002BE)
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Internal remarks:
Oral LD50 1300 mg/Kg
Endpoint study
#2: Alaoui, Katim., Belabbes, Mohamed., Cherrah, Yahia., Hassar, Mohamed., Charrouf, Zoubida., Amarouch, Hamid., Roquebert, Jacques. Acute and chronic toxicity of saponins of Argania spinosa. annales pharmaceutiques francaises, 1998, vol. 56, no. 5, p. 213–219. .
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Study relevance:
Human health
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Substance:
Saponins (RF-00004333-PAR)
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Plant part:
Unspecified (A07XD)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
Water
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Type of toxicological test:
chronic/long term toxicity (CHD004TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Unit of exposure duration:
Month (G206A)
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Control groups used:
no data
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligram/kilogram (G061A)
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Effect concentration:
100-200
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Critical effect:
NEPHROTOXICITY (TOX03A)
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Target tissue:
urogenital: Kidneys (TT046A)
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Effect description:
no data
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Effect or parameter linked to the endpoint:
no data (CHD002BE)
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Internal remarks:
Chronic toxicity: hepatic glycogen decrease and a focal renal tube deterioration.