EFSA
ecomole
vscht
  2. Areca (as plant) // Areca catechu L.

Areca (as plant) // Areca catechu L.

Family:
Arecaceae
Approval state:
Approved
Number of articles retrieved:
2122
Number of processed references:
5
Compositions
#1: harman in nuts #2: harmol in nuts #3: harmine in nuts #4: harmalol in nuts #5: norharman in nuts #6: arecaidine in nuts #7: tannins in nuts #8: arecoline in nuts
Endpoint Studies
Genotoxicity
#1: abberant metaphases increased #2: chromosomal aberation increased #3: genotoxicity in salmonella typhimurium assay #4: increased frequency of chromosomal abberation in mice #5: increased frequency of micronuclei in mice #6: induction of sister chromatid exchanges in human peripheral blood lymphocytes
Composition #1: Tsuchiya, Hironori., Hayashi, Hideaki., Sato, Masaru., Shimizu, Hiroshi., Iinuma, Munekazu. Quantitative analysis of all types of β-carboline alkaloids in medicinal plants and dried edible plants by high performance liquid chromatography with selective fluorometric detection. phytochemical analysis, 1999, vol. 10, no. 5, p. 247–253. .
Composition #2: Tsuchiya, Hironori., Hayashi, Hideaki., Sato, Masaru., Shimizu, Hiroshi., Iinuma, Munekazu. Quantitative analysis of all types of β-carboline alkaloids in medicinal plants and dried edible plants by high performance liquid chromatography with selective fluorometric detection. phytochemical analysis, 1999, vol. 10, no. 5, p. 247–253. .
Composition #3: Tsuchiya, Hironori., Hayashi, Hideaki., Sato, Masaru., Shimizu, Hiroshi., Iinuma, Munekazu. Quantitative analysis of all types of β-carboline alkaloids in medicinal plants and dried edible plants by high performance liquid chromatography with selective fluorometric detection. phytochemical analysis, 1999, vol. 10, no. 5, p. 247–253. .
Composition #4: Tsuchiya, Hironori., Hayashi, Hideaki., Sato, Masaru., Shimizu, Hiroshi., Iinuma, Munekazu. Quantitative analysis of all types of β-carboline alkaloids in medicinal plants and dried edible plants by high performance liquid chromatography with selective fluorometric detection. phytochemical analysis, 1999, vol. 10, no. 5, p. 247–253. .
Composition #5: Tsuchiya, Hironori., Hayashi, Hideaki., Sato, Masaru., Shimizu, Hiroshi., Iinuma, Munekazu. Quantitative analysis of all types of β-carboline alkaloids in medicinal plants and dried edible plants by high performance liquid chromatography with selective fluorometric detection. phytochemical analysis, 1999, vol. 10, no. 5, p. 247–253. .
Composition #6: Sharan, Rajesh N., Choudhury, Yashmin., Roy, D., Dorak, MT. Betel Nut and Susceptibility to Cancer. environmental factors, genes, and the development of human cancers, 2010, p. 401–428. DOI: 10.1007/978-1-4419-6752-7_15. [DOI link]
Composition #7: Sharan, Rajesh N., Choudhury, Yashmin., Roy, D., Dorak, MT. Betel Nut and Susceptibility to Cancer. environmental factors, genes, and the development of human cancers, 2010, p. 401–428. DOI: 10.1007/978-1-4419-6752-7_15. [DOI link]
Composition #8: Sharan, Rajesh N., Choudhury, Yashmin., Roy, D., Dorak, MT. Betel Nut and Susceptibility to Cancer. environmental factors, genes, and the development of human cancers, 2010, p. 401–428. DOI: 10.1007/978-1-4419-6752-7_15. [DOI link]
Genotox #1: Dave, Bhavana J., Trivedi, Amit H., Adhvaryu, Siddharth G. In vitro genotoxic effects of areca nut extract and arecoline. journal of cancer research and clinical oncology, 1992, vol. 118, no. 4, p. 283–288. .
Genotox #2: Dave, Bhavana J., Trivedi, Amit H., Adhvaryu, Siddharth G. In vitro genotoxic effects of areca nut extract and arecoline. journal of cancer research and clinical oncology, 1992, vol. 118, no. 4, p. 283–288. .
Genotox #3: Polasa, K., Babu, S., Shenolikar, I.S. Dose-dependent genotoxic effect of pan masala and areca nut in the Salmonella typhimurium assay. food and chemical toxicology, 1993, vol. 31, no. 6, p. 439–442. DOI: 10.1016/0278-6915(93)90160-Z. [DOI link]
Genotox #4: Kumpawat, K., Deb, S., Ray, S., Chatterjee, A. Genotoxic effect of raw betel-nut extract in relation to endogenous glutathione levels and its mechanism of action in mammalian cells . mutation research-genetic toxicology and environmental mutagenesis, 2003, vol. 538, no. 1-2, p. 1–12. DOI: 10.1016/S1383-5718(03)00048-2. [DOI link]
Genotox #5: Kumpawat, K., Deb, S., Ray, S., Chatterjee, A. Genotoxic effect of raw betel-nut extract in relation to endogenous glutathione levels and its mechanism of action in mammalian cells . mutation research-genetic toxicology and environmental mutagenesis, 2003, vol. 538, no. 1-2, p. 1–12. DOI: 10.1016/S1383-5718(03)00048-2. [DOI link]
Genotox #6: Kumpawat, K., Deb, S., Ray, S., Chatterjee, A. Genotoxic effect of raw betel-nut extract in relation to endogenous glutathione levels and its mechanism of action in mammalian cells . mutation research-genetic toxicology and environmental mutagenesis, 2003, vol. 538, no. 1-2, p. 1–12. DOI: 10.1016/S1383-5718(03)00048-2. [DOI link]