EFSA Compendium of Botanicals

Draft - work in progress

Aralia elata var. mandshurica (Rupr. & Maxim.) J.Wen // Aralia mandshurica Rupr. & Maxim.

Family:: Araliaceae
Approval state:: Approved
Number of articles retrieved:: 119
Number of processed references:: 3

Compositions

Endpoint Studies

#1: LD50 in rats #2: hepatobiliary toxicity

Genotoxicity

Composition #1: Kochetkov, N. K., Khorlin, A. Ya., Vas'kovskii, V. E. Structures of aralosides A and B. tetrahedron letters, 1962, p. 713–16. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Triterpene saponins Triterpene saponins (RF-00004338-PAR)
Additional substance description:

aralosides A, B and C
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

aralosides A, B and C in roots

Endpoint study #1: BURGOS, R., HANCKE, J., WIKMAN, G., CUBILLOS, V., CABALLERO, E., OYARZO, M., SANCHEZ, N. TOXICOLOGICAL ASSESSMENT OF ARALIA-MANDSHURICA (ARALIACEAE) ROOT EXTRACT AFTER SUBCHRONIC ADMINISTRATION IN RATS - A BIOCHEMICAL AND HISTOLOGICAL STUDY . phytotherapy research, 1994, vol. 8, no. 1, p. 1–9. DOI: 10.1002/ptr.2650080102. [DOI link]

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

Dried root extract of Aralia mandshurica (Araliaceae), standardized to a minimum of 3% of aralosides
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Sprague-Dawley (CHD012ST)
Sex:

Male/Female
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration:

24.0
Unit of exposure duration:

Hour (G099A)
Number of organisms dosed:

50
Control groups used:

no data
Endpoint measured:

Dose producing lethality in 50% of experimental organisms (CHD024EP)
Concentration unit:

Gram/kilogram (G015A)
Effect concentration:

16.5-16.8
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

neurologic: Central Nervous System (TT035A)
Effect description:

Before death depressant effects on the central nervous system with diminution of the motor activity, frequent micturition, respiratory difficulty and diarrhoea.
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

LD50 in rats

Endpoint study #2: Burgos, RA., Hancke, JL., Caceres, DD., Wilkman, G., Fuenzalida, H. Hepatotoxic effect of Aralia mandshurica dried root extract in pigs. phytotherapy research, 1997, vol. 11, no. 1, p. 59–61. DOI: 10.1002/(SICI)1099-1573(199702)11:1<59::AID-PTR944>3.0.CO;2-8. [DOI link]

Study relevance:

Animal (target species) health
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

solvent extract unspecified
Type of toxicological test:

subchronic (CHD013TT)
Tested organism:

Pig (as animal) (A057F)
Strain of test organism:

Large White x Landrace (CHD021ST)
Sex:

Male/Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

60.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

24
Control groups used:

yes
Endpoint measured:

Lowest observable effect concentration (CHD027EP)
Concentration unit:

Gram/kilogram (G015A)
Effect concentration:

0.16
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

hepatobiliary toxic effects; periportal inflammation with destruction of the periportal area ; incresed levels of ALT and gGT
Effect or parameter linked to the endpoint:

haematology (CHD023BE)
Internal remarks:

hepatobiliary toxicity